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Summary

ACRIN 6688, a [18F]-fluorothymidine (FLT) imaging study using positron emission tomography (PET),   was designed to evaluate the relationship between [18F] FLT uptake parameters and pathologic complete response to neoadjuvant therapy of the primary tumor in patients with locally advanced breast cancer.

Participant Eligibility and Enrollment: Criteria for inclusion were patients with pathologically confirmed breast cancer and determined to be a candidate for primary systemic (neoadjuvant) therapy and for whom surgical resection of residual primary tumor following completion of neoadjuvant therapy is planned. The study was open to enrollment from September 2009 to September 2012. Final accrual to the study was 90 patients, of which 80 were included in the analysis.

Acknowledgements

This shared data set was provided by Paul R. Jolles, MD, and David Mankoff, MD, PhD, and Lale Kostakoglu, MD, MPH, in collaboration with the American College of Radiology Imaging network (ACRIN). Many thanks are due to the ACRIN 6688 trial team, and all the patients participating in the study.

This study was supported by ACRIN, which received funding from the National Cancer Institute through UO1 CA080098, under the American Recovery and Reinvestment ACT of 2009 (ARRA) and UO1 CA079778.


 

Data Access

This is a limited access data set and is only available to members of NCI's Quantitative Imaging Network (QIN) until 12/18/2018. If you are a member of the QIN and would like to request access, please submit a CCP proposal to the QIN Coordinating Committee. Once access is granted, you can view and download these images on The Cancer Imaging Archive (TCIA) by logging in and selecting the ACRIN-FLT-Breast collection.

Data TypeDownload all or Query/Filter
Images (DICOM, 70.8 GB)

 

Click the Versions tab for more info about data releases.

Detailed Description

Collection Statistics

 

Modalities

CT, PT, OT

Number of Patients

83

Number of Studies

360

Number of Series

1498

Number of Images

678,406

Image Size (GB)70.8

 

Metadata

Much more information about this data set can be found https://www.acrin.org/6688_protocol.aspx

Citations & Data Usage Policy 

This is a limited access data set and is only available to members of NCI's Quantitative Imaging Network (QIN) until 12/11/2018. If you are a member of the QIN and would like to request access, please submit a CCP proposal to the QIN Coordinating Committee. Upon receiving access you may only use it for the purposes outlined in your proposal. You are not allowed to redistribute the data or use it for other purposes.  See TCIA's Data Usage Policies and Restrictions for additional details. Questions may be directed to help@cancerimagingarchive.net.

Please be sure to include the following citations in your work if you use this data set:

Data Citation

Kinahan, Paul; Bialecki, Brian; Coombs, Laura. (2017). Data from ACRIN-FLT-Breast. The Cancer Imaging Archive. http://doi.org/10.7937/K9/TCIA.2017.ol20zmxg

Publication Citation

Kostakoglu LDuan FIdowu MOJolles PRBear HDMuzi MCormack JMuzi JPPryma DASpecht JMHovanessian-Larsen LMiliziano JMallett SShields AFMankoff DAACRIN 668 Investigative Team. A Phase II Study of 3'-Deoxy-3'-18F-Fluorothymidine PET in the Assessment of Early Response of Breast Cancer to Neoadjuvant Chemotherapy: Results from ACRIN 6688. J Nucl Med. 2015 Nov;56(11):1681-9. doi: 10.2967/jnumed.115.160663. Epub 2015 Sep 10. (link)

TCIA Citation

Clark K, Vendt B, Smith K, Freymann J, Kirby J, Koppel P, Moore S, Phillips S, Maffitt D, Pringle M, Tarbox L, Prior F. The Cancer Imaging Archive (TCIA): Maintaining and Operating a Public Information Repository, Journal of Digital Imaging, Volume 26, Number 6, December, 2013, pp 1045-1057. (paper)

Other Publications Using This Data

TCIA maintains a list of publications which leverage our data. At this time we are not aware of any publications based on this data. If you have a publication you'd like to add please contact the TCIA Helpdesk.

Version 1 (Current): Updated 2017/12/11

Data TypeDownload all or Query/Filter
Images (DICOM, 70.8 GB)

 

 

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