Child pages
  • NSCLC-Cetuximab
Skip to end of metadata
Go to start of metadata

Summary

This collection contains data from the National Cancer Insitute Clinical Trial NCT00533949, "High-Dose or Standard-Dose Radiation Therapy and Chemotherapy With or Without Cetuximab in Treating Patients With Newly Diagnosed Stage III Non-Small Cell Lung Cancer That Cannot Be Removed by Surgery."  It was sponsored by NCI's Radiation Therapy Oncology Group (RTOG) under study number RTOG-0617.

Trial Description

Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as paclitaxel, carboplatin work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as cetuximab can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. It is not yet known whether high-dose radiation therapy is more effective than standard-dose radiation therapy when given together with combination chemotherapy with or without cetuximab in treating patients with non-small cell lung cancer.

This randomized phase III trial is studying high-dose or standard-dose radiation therapy given together with chemotherapy with or without cetuximab to see how well they work in treating patients with newly diagnosed stage III non-small cell lung cancer that cannot be removed by surgery.

For more information about the imaging protocol of this trial please see this document: https://www.rtog.org/LinkClick.aspx?fileticket=EmCYRSsCnRA%3d&tabid=40

Trial Outcomes 

Results of the trial have been reported in the following publications:

  1. Movsas B, Hu C, Sloan J, Bradley J, Komaki R, Masters G, Kavadi V, Narayan S, Michalski J, Johnson DW, Koprowski C, Curran WJ Jr, Garces YI, Gaur R, Wynn RB, Schallenkamp J, Gelblum DY, MacRae RM, Paulus R, Choy H. Quality of Life Analysis of a Radiation Dose-Escalation Study of Patients With Non-Small-Cell Lung Cancer: A Secondary Analysis of the Radiation Therapy Oncology Group 0617 Randomized Clinical Trial. JAMA Oncol. 2016 Mar;2(3):359-67. doi: 10.1001/jamaoncol.2015.3969. (link)

  2. Bradley JD, Paulus R, Komaki R, Masters G, Blumenschein G, Schild S, Bogart J, Hu C, Forster K, Magliocco A, Kavadi V, Garces YI, Narayan S, Iyengar P, Robinson C, Wynn RB, Koprowski C, Meng J, Beitler J, Gaur R, Curran W Jr, Choy H. Standard-dose versus high-dose conformal radiotherapy with concurrent and consolidation carboplatin plus paclitaxel with or without cetuximab for patients with stage IIIA or IIIB non-small-cell lung cancer (RTOG 0617): a randomised, two-by-two factorial phase 3 study. Lancet Oncol. 2015 Feb;16(2):187-99. doi: 10.1016/S1470-2045(14)71207-0. Epub 2015 Jan 16. (link)


Data Access

This is a limited access data set. To request access, please follow instructions in the NCTN/NCORP Data Archive Usage Guide. Once access is granted, click the Download button to save a ".tcia" manifest file to your computer, which you must open with the NBIA Data Retriever. Click the Search button to open our Data Portal, where you can browse the data collection and/or download a subset of its contents.

Data TypeDownload all or Query/Filter
Images ( 42.7GB)

 

Clinical Data on NCTN Data Archive

Click the Versions tab for more info about data releases.

Detailed Description

Collection Statistics

 

Modalities

CT, RTSTRUCT, RTDOSE, RTPLAN

Number of Patients

490

Number of Studies

490

Number of Series

2116

Number of Images

75063

Image Size (GB)42.7

Citations & Data Usage Policy 

This is a limited access data set. Upon receiving access you may only use it for the purposes outlined in your request to the data provider. You are not allowed to redistribute the data or use it for other purposes. See TCIA's Data Usage Policies and Restrictions for additional details. Questions may be directed to help@cancerimagingarchive.net.


Please be sure to include the following citations in your work if you use this data set:

Data Citation

Bradley, Jeffrey; Forster, Ken. (2018). Data from NSCLC-Cetuximab. The Cancer Imaging Archive. http://doi.org/10.7937/TCIA.2018.jze75u7v

TCIA Citation

Clark K, Vendt B, Smith K, Freymann J, Kirby J, Koppel P, Moore S, Phillips S, Maffitt D, Pringle M, Tarbox L, Prior F. The Cancer Imaging Archive (TCIA): Maintaining and Operating a Public Information Repository, Journal of Digital Imaging, Volume 26, Number 6, December, 2013, pp 1045-1057. (paper)

Other Publications Using This Data

See the TCIA Publications page for other work leveraging this collection. If you have a publication you'd like to add please contact the TCIA Helpdesk.

Version 1 (Current): Updated 2018/11/20

Data TypeDownload all or Query/Filter
Images ( 42.7GB)

 

Clinical Data on NCTN Data Archive

  • No labels