SummaryThe Cancer Genome Atlas Low Grade Glioma (TCGA-LGG) data collection is part of a larger effort to build a research community focused on connecting cancer phenotypes to genotypes by providing clinical images matched to subjects from The Cancer Genome Atlas (TCGA). Clinical, genetic, and pathological data resides in the Genomic Data Commons (GDC) Data Portal while the radiological data is stored on The Cancer Imaging Archive (TCIA).
Matched TCGA patient identifiers allow researchers to explore the TCGA/TCIA databases for correlations between tissue genotype, radiological phenotype and patient outcomes. Tissues for TCGA were collected from many sites all over the world in order to reach their accrual targets, usually around 500 specimens per cancer type. For this reason the image data sets are also extremely heterogeneous in terms of scanner modalities, manufacturers and acquisition protocols. In most cases the images were acquired as part of routine care and not as part of a controlled research study or clinical trial.
CIP TCGA Radiology Initiative
Imaging Source Site (ISS) Groups are being populated and governed by participants from institutions that have provided imaging data to the archive for a given cancer type. Modeled after TCGA analysis groups, ISS groups are given the opportunity to publish a marker paper for a given cancer type per the guidelines in the table above. This opportunity will generate increased participation in building these multi-institutional data sets as they become an open community resource. Learn more about the TCGA Glioma Phenotype Research Group.
We would like to acknowledge the individuals and institutions that have provided data for this collection:
- Thomas Jefferson University, Philadelpha, PA - Special thanks to Nancy Pedano and Adam E. Flanders, MD from the Department of Radiology, Jefferson Medical College.
- Henry Ford Hospital, Detroit, MI - Special thanks to Lisa Scarpace and Tom Mikkelsen, MD from the Department of Neurosurgery, Hermelin Brain Tumor Center.
- Saint Joseph Hospital and Medical Center, Phoenix, AZ - Special thanks to Jennifer M. Eschbacher, MD and Beth Hermes from the Department of Neuropathology/Pathology and to Victor Sisneros, PACS Administrator.
- Case Western Reserve University, Cleveland, OH -Special thanks to Jill Barnholtz, MD. and Quinn Ostrom.
- University of North Carolina, Chapel Hill, NC - Special thanks to J. Keith Smith, M.D.,Ph.D. and Shanah Kirk.
Click the Download button to save a ".tcia" manifest file to your computer, which you must open with the NBIA Data Retriever. Click the Search button to open our Data Portal, where you can browse the data collection and/or download a subset of its contents.
|Data Type||Download all or Query/Filter|
|Images (DICOM, 42.8GB)|
|Tissue Slide Images (web)|
|Clinical Data (TXT)|
Click the Versions tab for more info about data releases.
Third Party Analyses of this Dataset
TCIA encourages the community to publish your analyses of our datasets. Below is a list of such third party analyses published using this Collection:
Number of Patients
Number of Studies
Number of Series
Number of Images
|Images Size (GB)||42.8|
GDC Data Portal - Clinical and Genomic Data
The GDC Data Portal has extensive clinical and genomic data, which can be matched to the patient identifiers on the images here in TCIA. Below is a snapshot of clinical data extracted on 1/5/2016.
Explanations of the clinical data can be found on the Biospecimen Core Resource Clinical Data Forms linked below:
A Note about TCIA and TCGA Subject Identifiers and Dates
Subject Identifiers: a subject with radiology images stored in TCIA is identified with a Patient ID that is identical to the Patient ID of the same subject with demographic, clinical, pathological, and/or genomic data stored in TCGA. For each TCGA case, the baseline TCGA imaging studies found on TCIA are pre-surgical.
Dates: TCIA and TCGA handle dates differently, and there are no immediate plans to reconcile:
- TCIA Dates: dates (be they birth dates, imaging study dates, etc.) in the Digital Imaging and Communications in Medicine (DICOM) headers of TCIA radiology images have been offset by a random number of days. The offset is a number of days between 3 and 10 years prior to the real date that is consistent for each TCIA image-submitting site and collection, but that varies among sites and among collections from the same site. Thus, the number of days between a subject’s longitudinal imaging studies are accurately preserved when more than one study has been archived while still meeting HIPAA requirements.
- TCGA Dates: the patient demographic and clinical event dates are all the number of days from the index date, which is the actual date of pathologic diagnosis. So all the dates in the data are relative negative or positive integers, except for the “days_to_pathologic_diagnosis” value, which is 0 – the index date. The years of birth and diagnosis are maintained in the distributed clinical data file. The NCI retains a copy of the data with complete dates, but those data are not made available.With regard to other TCGA dates, if a date comes from a HIPAA “covered entity’s” medical record, it is turned into the relative day count from the index date. Dates like the date TCGA received the specimen or when the TCGA case report form was filled out are not such covered dates, and they will appear as real dates (month, day, and year).
Citations & Data Usage Policy
This collection is freely available to browse, download, and use for commercial, scientific and educational purposes as outlined in the Creative Commons Attribution 3.0 Unported License. See TCIA's Data Usage Policies and Restrictions for additional details. Questions may be directed to firstname.lastname@example.org.
Please be sure to include the following attribution and citations in your work if you use this data set:
Pedano, N., Flanders, A. E., Scarpace, L., Mikkelsen, T., Eschbacher, J. M., Hermes, B., … Ostrom, Q. (2016). Radiology Data from The Cancer Genome Atlas Low Grade Glioma [TCGA-LGG] collection. The Cancer Imaging Archive. http://doi.org/10.7937/K9/TCIA.2016.L4LTD3TK
Clark K, Vendt B, Smith K, Freymann J, Kirby J, Koppel P, Moore S, Phillips S, Maffitt D, Pringle M, Tarbox L, Prior F. The Cancer Imaging Archive (TCIA): Maintaining and Operating a Public Information Repository, Journal of Digital Imaging, Volume 26, Number 6, December, 2013, pp 1045-1057. (paper)
Other Publications Using This Data
TCIA maintains a list of publications which leverage our data.
- Buda, Mateusz et al. "Association of Genomic Subtypes of Lower-Grade Gliomas with Shape Features Automatically Extracted by a Deep Learning Algorithm." Computers in Biology and Medicine, vol. 109, 2019, pp. 218-225, doi:10.1016/j.compbiomed.2019.05.002.
- Chang, Ken et al. "Residual Convolutional Neural Network for the Determination of Idh Status in Low-and High-Grade Gliomas from Mr Imaging." Clinical Cancer Research, vol. 24, no. 5, 2018, pp. 1073-1081, doi:10.1158/1078-0432.CCR-17-2236.
- Chang, Ken et al. "Automatic Assessment of Glioma Burden: A Deep Learning Algorithm for Fully Automated Volumetric and Bi-Dimensional Measurement." Neuro Oncol, 2019, doi:10.1093/neuonc/noz106.
- Chang, P et al. "Deep-Learning Convolutional Neural Networks Accurately Classify Genetic Mutations in Gliomas." American Journal of Neuroradiology, 2018, pp. 1-7, doi:10.3174/ajnr.A5667.
- Halani, Sameer H et al. "Multi-Faceted Computational Assessment of Risk and Progression in Oligodendroglioma Implicates Notch and Pi3k Pathways." NPJ precision oncology, vol. 2, no. 1, 2018, p. 24, doi:10.1038/s41698-018-0067-9 .
- Hsieh, Kevin Li-Chun et al. "Computer-Aided Grading of Gliomas Based on Local and Global Mri Features." Computer Methods and Programs in Biomedicine, vol. 139, 2016, pp. 31-38.
- Hu, Kai et al. "Brain Tumor Segmentation Using Multi-Cascaded Convolutional Neural Networks and Conditional Random Field." IEEE Access, vol. 7, 2019, pp. 92615-92629, doi:10.1109/access.2019.2927433.
- Iqbal, Sajid et al. "Brain Tumor Segmentation in Multi‐Spectral Mri Using Convolutional Neural Networks (Cnn)." Microscopy research and technique, vol. 81, no. 4, 2018, pp. 419-427, doi:doi.org/10.1002/jemt.22994.
Jiang, Chendan et al. "Fusion Radiomics Features from Conventional Mri Predict Mgmt Promoter Methylation Status in Lower Grade Gliomas." Eur J Radiol, vol. 121, 2019, p. 108714, doi:10.1016/j.ejrad.2019.108714.
- Juratli, Tareq A et al. "Radiographic Assessment of Contrast Enhancement and T2/Flair Mismatch Sign in Lower Grade Gliomas: Correlation with Molecular Groups." Journal of Neuro-Oncology, 2018, pp. 1-9, doi:10.1007/s11060-018-03034-6.
- Lambrecht, Joren. "Textural Analysis of Tumour Imaging: A Radiomics Approach." Electronics and Information Systems, vol. MS in Biomedical Engineering, Ghent University, 2017, p. 108. general editor, Prof. dr. Roel Van Holen, (Link to Thesis)
- Lehrer, Michael et al. "Multiple-Response Regression Analysis Links Magnetic Resonance Imaging Features to De-Regulated Protein Expression and Pathway Activity in Lower Grade Glioma." Oncoscience, vol. 4, no. 5-6, 2017, p. 57.
- Li, Y. et al. "Genotype Prediction of Atrx Mutation in Lower-Grade Gliomas Using an Mri Radiomics Signature." Eur Radiol, 2018, doi:10.1007/s00330-017-5267-0.
- Liu, Z., Zhang, T., Jiang, H., Xu, W., & Zhang, J. (2018). "Conventional MR-based preoperative nomograms for prediction of IDH/1p19q subtype in low-grade glioma" Academic Radiology. DOI: 10.1016/j.acra.2018.09.022
- Lu, Chia-Feng et al. "Machine Learning-Based Radiomics for Molecular Subtyping of Gliomas." Clinical Cancer Research, 2018, p. clincanres. 3445.2017, doi:10.1158/1078-0432.CCR-17-3445.
- Mazurowski, Maciej A et al. "Radiogenomics of Lower-Grade Glioma: Algorithmically-Assessed Tumor Shape Is Associated with Tumor Genomic Subtypes and Patient Outcomes in a Multi-Institutional Study with the Cancer Genome Atlas Data." Journal of Neuro-Oncology, 2017, pp. 1-9.
- Nakamoto, Takahiro et al. "Prediction of Malignant Glioma Grades Using Contrast-Enhanced T1-Weighted and T2-Weighted Magnetic Resonance Images Based on a Radiomic Analysis." Sci Rep, vol. 9, no. 1, 2019, p. 19411, doi:10.1038/s41598-019-55922-0.
- Patel, Sohil H et al. "Mri and Ct Identify Isocitrate Dehydrogenase (Idh)-Mutant Lower-Grade Gliomas Misclassified to 1p/19q Codeletion Status with Fluorescence in Situ Hybridization." Radiology, vol. 294, no. 1, 2020, pp. 160-167, doi:10.1148/radiol.2019191140.
- Rezaei, Mina et al. "Conditional Generative Adversarial Refinement Networks for Unbalanced Medical Image Semantic Segmentation." 2019 IEEE Winter Conference on Applications of Computer Vision (WACV), IEEE, 2019, pp. 1836-1845. doi:10.1109/WACV.2019.00200.
- Zeng, Ke et al. "Segmentation of Gliomas in Pre-Operative and Post-Operative Multimodal Magnetic Resonance Imaging Volumes Based on a Hybrid Generative-Discriminative Framework." International Workshop on Brainlesion: Glioma, Multiple Sclerosis, Stroke and Traumatic Brain Injuries, Springer, 2016, pp. 184-194.
- Zhou, Hao et al. "Mri Features Predict Survival and Molecular Markers in Diffuse Lower-Grade Gliomas." Neuro-Oncology, vol. 19, no. 6, 2017, pp. 862-870.
If you have a manuscript you'd like to add please contact the TCIA Helpdesk.
Version 2 (Current): Updated 2016/01/05
Extracted latest release of clinical data (TXT) from the GDC Data Portal.
Version 1: Updated 2014/09/04
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