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Description
This study describes a subset of the HNSCC collection on TCIA.
PURPOSE:
Cross sectional imaging is essential for the patient-specific planning and delivery of radiotherapy, a primary determinant of head and neck cancer outcomes. Publicly shared RT data is scarce due to high complexity of RT structure data and the need for registration in time, space, and across planning sets. We here introduce an open access imaging database for patients treated with radiotherapy for
Summary
Pre- and post-treatment scans from head and neck squamous cell carcinoma (HNSCC) patients treated with radiation therapy (RT) scans include full staging and follow up scans. The abdominal imaging was then also used to quantify body composition in these patients as part of a study into the prognostic impact of patients' muscle mass. These images of the torso do not include the head, as they were collected for another purpose.
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head and neck squamous cell carcinoma (HNSCC).
MATERIALS AND METHODS:
2840 consecutive patients with HNSCC treated with
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curative-intent RT at MD Anderson
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Cancer Center from 2003 to 2013 were screened. Patients with whole-body PET-CT or abdominal CT scans both before and after RT were included (n=215). Clinical data were retrieved from the MD Anderson Cancer Center custom electronic medical record system, ClinicStation. Using cross sectional imaging, we calculated total body skeletal muscle and adipose content before and after treatment. All files were de-identified and transferred to The Cancer Imaging Archive servers using the RSNA Clinical Trial Processor program. Files were screened for errors or residual PHI using TagSniffer and Posda Tools software, reviewed by TCIA curators, then confirmed at the parent institution.
RESULTS:
The HNSCC collection is a dataset consisting of 433,384 DICOM files from 3,225 series and 765 studies collected from 215 patients, which includes de-identified diagnostic imaging, radiation treatment planning, and follow up imaging. All imaging data are subject- and date-matched to clinical data from each patient, including demographics, risk factors, grade, stage, recurrence, and survival.
CONCLUSION:
Recent advances in data archiving, patient de-identification, and image registration have allowed for the creation of a high quality RT-enriched imaging database within TCIA. Open access to these data allows for interinstitutional comparisons of complete RT details in non-randomized patient populations, allowing for a more granular understanding of three dimensional factors that influence treatment effectiveness and toxicity sparing.
A related dataset describing the other component of the the HNSCC collection is here: Radiomics outcome prediction in Oropharyngeal cancer DOI: 10.7937/TCIA.2020.2vx6-fy46
Acknowledgements:
This research was supported by the Andrew Sabin Family Foundation; Dr. Fuller is a Sabin Family Foundation Fellow. Drs. Mohamed and Fuller receive funding support from the National Institutes of Health (NIH)/National Institute for Dental and Craniofacial Research (NIDCR) (R01DE025248) and the National Institutes of Health (NIH)/National Cancer Institute (NCI) (1R01CA214825-01). Dr. Fuller received/(s) grant and/or salary support from the NIH/NCI Head and Neck Specialized Programs of Research Excellence (SPORE) Developmental Research Program Career Development Award (P50CA097007-10); the NCI Paul Calabresi Clinical Oncology Program Award (K12 CA088084-06); a General Electric Healthcare/MD Anderson Center for Advanced Biomedical Imaging In-Kind Award; an Elekta AB/MD Anderson Department of Radiation Oncology Seed Grant; the Center for Radiation Oncology Research (CROR) at MD Anderson Cancer Center Seed Grant; the MD Anderson Institutional Research Grant (IRG) Program; and the NIH/NCI Cancer Center Support (Core) Grant CA016672 to The University of Texas MD Anderson Cancer Center (P30 CA016672). Dr. Elhalawani was directly funded in part by a philanthropic gift from the Family of Paul W. Beach given to Dr. Gunn for patient-outcome database construction.
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| title | Data Access |
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| Data Access |
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Choosing the Download option will provide you with a file to launch the TCIA Download Manager to download the entire collection. If you want to browse or filter the data to select only specific scans/studies please use the Search By Collection option.
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| Images and Radiation Therapy Structures (DICOM |
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| ) | | | | Clinical (XLS) | | | | Data Dictionary (XLS) | | |
Please contact help@cancerimagingarchive.net with any questions regarding usage.
Collections Used in this Third Party AnalysisBelow is a list of the Collections used in these analyses: |
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| title | Detailed Description |
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| Detailed Description |
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| Radiological Image statistics |
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Modalities | CT, MR, PT, |
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RTDOSE | Number of Patients | 215 | Number of Studies |
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Note
–Demographics
–Tumor characteristics
–Treatment characteristics
–Survival
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Note from the investigators: Some PET scans will include two PET AC files—one includes the head & neck portion of the exam, the other includes eyes-to-thighs. There is no file naming convention to distinguish between the two, so delineation may require the use of a DICOM viewer. |
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| title | Citations & Data Usage Policy |
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| Citations & Data Usage Policy |
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This collection is freely available to browse, download, and use for commercial, scientific and educational purposes as outlined in the Creative Commons Attribution 3.0 Unported License. See TCIA's Data Usage Policies and Restrictions for additional details. Questions may be directed to help@cancerimagingarchive.net.
Please be sure to include the following citations in your work if you use this data set:
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A, Elhalawani H, Bennett W, Smith K, Nolan T, Chamchod S, Kantor M, Browne T, Hutcheson K, Gunn G, Garden A, Frank S, R osenthal D, Freymann J, Fuller C.(2017). Data from Head and Neck Cancer CT Atlas. The Cancer Imaging Archive. |
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| title | Publication Citation |
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Grossberg A, Mohamed A, Elhalawani H, Bennett W, Smith K, Nolan T, Williams B, Chamchod S, Heukelom J, Kantor M, Browne T, Hutcheson K, Gunn G, Garden A, Morrison W, Frank S, R osenthal D, Freymann J, Fuller C. (2018) Imaging and Clinical Data Archive for Head and Neck Squamous Cell Carcinoma Patients Treated with Radiotherapy. Scientific Data 5 :180173 (2018) DOI: 10.1038/sdata.2018.173
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| Clark K, Vendt B, Smith K, Freymann J, Kirby J, Koppel P, Moore S, Phillips S, Maffitt D, Pringle M, Tarbox L, Prior F. |
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(2013) The Cancer Imaging Archive (TCIA): Maintaining and Operating a Public Information Repository, Journal of Digital Imaging, |
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Other Publications Using This Data |
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TCIA maintains a list of publications that leverage TCIA data. If you have a manuscript you'd like to add please contact the TCIA Helpdesk. Below are some of the gathered publications using this data: - Chamchod S., et al. Quantitative body mass characterization before and after head and neck cancer radiotherapy: A challenge of height-weight formulae using computed tomography measurement. Oral Oncol. 2016 Oct;61:62-9. doi: 10.1016/j.oraloncology.2016.08.012.
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–Evaluation of relationship between imaging-based body composition and anthropometrics
- Grossberg AJ, Chamchod S, Fuller CD, et al.
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- Association of Body Composition
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- With Survival and Locoregional Control
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- of Radiotherapy-Treated Head and Neck
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–Evaluation of relationship between body composition and oncologic outcomes
If you have a publication you'd like to add please contact the TCIA Helpdesk.
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| Version 1 (Current): |
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