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The Cancer Genome Atlas (TCGA) began began in 2006 as a three-year pilot jointly sponsored by the National Cancer Institute (NCI) and National Human Genome Research Institute (NHGRI). The TCGA pilot project (focused initially on glioblastoma, ovary, and lung cancers) confirmed that an atlas of genomic changes could be constructed for specific cancer types. It also showed that national networks of research and technology teams working on related projects could pool their efforts, create an economy of scale, and develop an infrastructure for making the data publicly accessible. The success of that pilot encouraged the National Institutes of Health (NIH) to invest in TCGA’s efforts to collect and characterize more than 20 additional tumor types and make findings freely accessible for researchers to download.  

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