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Summary

Excerpt
The Cancer Genome Atlas (TCGA) Breast Phenotype Research Group is part of the Cancer Imaging Program (CIP) Project TCGA Radiology Initiative focused on analyzing images from the TCGA-BRCA collection. These images correlate to the Breast Invasive Carcinoma (BRCA) data in the TCGA Data Portal.

According to TCGA’s page on invasive breast cancers, researchers have:

  • Described new integrated insights into the four standard molecular subtypes of breast cancer: HER2-enriched, luminal A, luminal B, and basal-like.
  • Identified mutated genes specific to each subtype.
  • Found that the basal-like subtype shares many genetic features with high-grade serous ovarian cancer, suggesting that these cancers have a common molecular origin and may share therapeutic opportunities.
  • Performed computational analyses suggesting that basal-like breast cancer and serous ovarian cancer might be susceptible to two types of cancer treatment:
    • Anti-angiogenesis drugs that inhibit blood vessel growth, cutting off blood supply to the tumor;
    • Bioreductive drugs, which are normally inactive but become toxic to cancer cells under low oxygen conditions.

TCGA Breast Marker Paper and Image Source Sites (ISS)

; an effort to build a research community focused on connecting cancer phenotypes to genotypes by providing clinical images matched to tissue specimens analyzed for The Cancer Genome Atlas (TCGA).

Imaging Source Site (ISS) groups will be populated Groups are being formed and governed by participants from institutions that have provided imaging data to the archive for a given cancer type. Modeled after TCGA analysis groups, ISS groups are given the opportunity to publish a marker paper for a given cancer type per the type per the guidelines in the table belowabove. This opportunity will generate increased participation in building these multi-institutional data sets as they become an open community resource. Current  Current TCGA-BRCA source  source sites include:

  • Mayo Clinic
  • Roswell Park Cancer Institute
  • MemorialSloan-KetteringCancerCenter
  • University of Pittsburgh/UPMC
  • University of Miami Health System

The ISS group has also been collaborating with the University of Chicago to conduct quantitative MRI phenotyping efforts.  Please contact Dr. Elizabeth Morris (morrise@mskcc.org) if you have scientific questions for TCGA-BRCA ISS or are interested in collaborating with their group.

Publications

TCGA Breast Phenotype Research

...

Group Publications

  • Manuscripts written by the group will be listed here as they are published.

Publications written by other members of the research community can be found on our TCIA Publications page.  Please contact us at help@cancerimagingarchive.net if you have a publication you would like us to add.

TCGA Genomics Publications

 Read the Cell paper about the TCGA-BRCA genomic study.  Additional TCGA publications can be found at: http://cancergenome.nih.gov/publications.

Publication Policies

Per TCGA and TCIA Guidelines, formal permission requests are no longer required to submit publications using TCGA-BRCA data.  Please see the following links for more information about the freedom-to-publish criteria for these data sets:

Data Source

Status

TCGA Data Portal Publication Guidelines

No restrictions; all data available without limitations.

TCIA Data Usage Policies and Restrictions

No restrictions; all data available without limitations.

Please contact us at help@cancerimagingarchive.net if  if you have any questions about these policies.

 

References

Conference abstracts utilizing TCGA-Breast imaging data from TCIA:

The following links contain publications from the main TCGA project as well as their posted publication guidelines: