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Summary

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locationhttps://www.cancerimagingarchive.net/collection/head-neck-cetuximab/
This collection combines advanced molecular imaging treatment response assessment through pre- and post-treatment FDG PET/CT scans with therapy of advanced head and neck cancer, including chemo-radiation therapy with and without addition of an EGFR inhibitor molecular targeted agent (Cetuximab). 

The Head-Neck Cetuximab collection consists of a subset of image data from RTOG 0522/ACRIN 4500, which was randomized phase III Trial of Radiation Therapy and Chemotherapy for stage III and IV Head and Neck carcinomas. The RTOG 0522 /ACRIN 4500 protocols were activated in November 2005 and successfully completed accrual of 945 patients in 2009. As part of the RTOG 0522 trial, CT, Structures, RT Doses, RT Plans were collected by RTOG, and institutions had the option to join the RTOG 0522/ACRIN 4500 imaging studya related quantitative PET (PET/CT) imaging study with ACRIN. The post-treatment FDG PET/CT scan was performed 8-9 weeks after completion of treatment before any nodal dissection.  For this reason the data was provided through two independent channels:

  • RTOG 0522: CT, Structures, RT Doses, RT Plans sent to ITC
  • ACRIN 4500: Quantitative PET (PET/CT) sent to ACRIN

    For more information about the original aims of this trial please see this oral abstract: J Clin Oncol 29: 2011 (suppl; abstr 5500) here: https://meetinglibrary.asco.org/record/63118/video . clinicaltrials.gov/ct2/show/results/NCT00265941?term=rtog0522 and this PDF.

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    Localtab
    activetrue
    titleData Access

    Data Access

    Choosing the Download option will provide you with a file to launch the TCIA Download Manager to download the entire collection. If you want to browse or filter the data to select only specific scans/studies please use the Search By Collection option.

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    Images
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    Images and Radiation Therapy Structures (48.8GB
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    urlhttps://wiki.cancerimagingarchive.net/download/attachments/6884551/TCIA_Head-Neck_Cetuximab_06-22-2015.tcia?version=1&modificationDate=1534787422712&api=v2



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    urlhttps://www.cancerimagingarchive.net/nbia-search/?CollectionCriteria=Head-Neck%20Cetuximab



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    urlhttps://wiki.cancerimagingarchive.net/download/attachments/6884551/HeadNeckCetuximab_MetaData.csv?version=2&modificationDate=1495560309184&api=v2



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    Localtab
    titleDetailed Description

    Detailed Description


    Collection Statistics

     


    Modalities

    PT, CT, RTSTRUCT, RTDOSE, RTPLAN

    Number of

    Patients

    Participants

    111

    Number of Studies

    368

    Number of Series

    1,682

    Number of Images

    202,574

    Image Size (GB)48.8


    Supporting Documentation and metadata

    Please note that 10 cases in this collection do not contain RT data.  Eight cases whose RT QA scores that were not "Per Protocol" or "Variation Acceptable" were excluded:  96, 133, 141, 143, 154, 182, 475, 478.  Also, subject 243 was ineligible and subject 260 expired prior to follow-up. 




    Localtab
    titleCitations & Data Usage Policy

    Citations & Data Usage Policy 

    This collection is freely available to browse, download, and use for commercial, scientific and educational purposes as outlined in the Creative Commons Attribution 3.0 Unported License.  See TCIA's Data Usage Policies and Restrictions for additional details. Questions may be directed to help@cancerimagingarchive.net.

    Please be sure to include the following citations in your work if you use this data set:

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    Info
    titleData Citation

    Bosch, Walter W. R., Straube, William W. L., Matthews, John J. W., & Purdy, James J. A. (2015). Data From Head-Neck _ Cetuximab [Data set]. The Cancer Imaging Archive. http https://doi.org/10.7937/K9/TCIA.2015.7AKGJUPZ


    Info
    titlePublication Citation

    Ang, K. K., Zhang, Q., Rosenthal, D. I., Nguyen-Tan, P. F., Sherman, E. J., Weber, R. S., Galvin, J. M., Bonner, J. A., Harris, J., El-Naggar, A. K., Gillison, M. L., Jordan, R. C., Konski, A. A., Thorstad, W. L., Trotti, A., Beitler, J. J., Garden, A. S., Spanos, W. J., Yom, S. S., & Axelrod, R. S. (2014). Randomized Phase III Trial of Concurrent Accelerated Radiation Plus Cisplatin With or Without Cetuximab for Stage III to IV Head and Neck Carcinoma: RTOG 0522. In Journal of Clinical Oncology (Vol. 32, Issue 27, pp. 2940–2950). American Society of Clinical Oncology (ASCO). https://doi.org/10.1200/jco.2013.53.5633


    Info
    titleTCIA Citation

    Clark, K., Vendt, B., Smith, K., Freymann, J., Kirby, J., Koppel, P., Moore, S., Phillips, S., Maffitt, D., Pringle, M., Tarbox, L., & Prior, F.  (2013). The Cancer Imaging Archive (TCIA): Maintaining and Operating a Public Information Repository, . In Journal of Digital Imaging , Volume (Vol. 26, Number Issue 6, December, 2013, pp 1045-1057. (paper)1045–1057). Springer Science and Business Media LLC. https://doi.org/10.1007/s10278-013-9622-7 PMCID: PMC3824915

    Other Publications Using This Data

    TCIA maintains

     a

     a list of publications

     which

     which leverage our

    data. At this time we are not aware of any publications based on this

    data.

     

    If you have a

    publication

    manuscript you'd like to add please

     contact the

     contact TCIA's Helpdesk.

    1. AlZu'bi, Shadi et al. "Transferable Hmm Probability Matrices in Multi‐Orientation Geometric Medical Volumes Segmentation." Concurrency and Computation: Practice and Experience, 2019, p. e5214, doi:10.1002/cpe.5214.
    2. Edwards, Samuel et al. "Automated 3-D Tissue Segmentation Via Clustering." Journal of Biomedical Engineering and Medical Imaging, vol. 5, no. 2, 2018, p. 08, doi: 10.14738/jbemi.52.4204.
    3. Gruselius, H. (2018).  Generative models and feature extraction on patient images and structure data in radiation therapy. Retrieved from  http://kth.diva-portal.org/smash/record.jsf?pid=diva2%3A1215620&dswid=2429

    4. Ryalat MH, Laycock S, Fisher M, editors.  Automatic Removal of Mechanical Fixations from CT Imagery with Particle Swarm Optimisation. International Conference on Bioinformatics and Biomedical Engineering; 2017: Springer. DOI:  10.1007/978-3-319-56148-6_37
    5. Sando, Yusuke et al. "Real-Time Interactive Holographic 3d Display with a 360 Degrees Horizontal Viewing Zone." Appl Opt, vol. 58, no. 34, 2019, pp. G1-G5, doi:10.1364/AO.58.0000G1.
    6. Scarpelli, M. et al. "Optimal Transformations Leading to Normal Distributions of Positron Emission Tomography Standardized Uptake Values." Phys Med Biol, vol. 63, no. 3, 2018, p. 035021, doi:10.1088/1361-6560/aaa175
    7. Sinha, A. et al. "The Deformable Most-Likely-Point Paradigm." Med Image Anal, vol. 55, 2019, pp. 148-164, doi:10.1016/j.media.2019.04.013.
    8. Sinha, A. et al. "Recovering Physiological Changes in Nasal Anatomy with Confidence Estimates." First International Workshop on Uncertainty for Safe Utilization of Machine Learning in Medical Imaging, UNSURE 2019, edited by Hayit Greenspan et al., Springer, 2019. doi:10.1007/978-3-030-32689-0_12.
    9. Tang, Hao et al. "Clinically Applicable Deep Learning Framework for Organs at Risk Delineation in Ct Images." Nature Machine Intelligence, vol. 1, no. 10, 2019, pp. 480-491, doi:10.1038/s42256-019-0099-z.
    10. Teske, Hendrik et al. "Handling Images of Patient Postures in Arms up and Arms Down Position Using a Biomechanical Skeleton Model." Current Directions in Biomedical Engineering, vol. 3, no. 2, 2017, pp. 469-472, doi:10.1515/cdbme-2017-0099.
    11. Wong, Jordan et al. "Comparing Deep Learning-Based Auto-Segmentation of Organs at Risk and Clinical Target Volumes to Expert Inter-Observer Variability in Radiotherapy Planning." Radiother Oncol, vol. 144, 2019, pp. 152-158, doi:10.1016/j.radonc.2019.10.019.
    12. Zhu, Wentao. "Deep Learning for Automated Medical Image Analysis." Computer Science, vol. Ph.D, University of California, Irvine, 15 March 2019 2019. general editor, Xiaohui Xie et al., https://arxiv.org/pdf/1903.04711.pdf.
    13. Zhu, Wentao et al. "Anatomynet: Deep Learning for Fast and Fully Automated Whole‐Volume Segmentation of Head and Neck Anatomy." Medical Physics, vol. 46, no. 2, 2018, pp. 576-589, doi:https://doi.org/10.1002/mp.13300





    Localtab
    titleVersions

    Version 1 (Current): Updated 2013/11/14


    Data TypeDownload all or Query/Filter
    Images (48.8GB)
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    Tcia button generator
    urlhttps://wiki.cancerimagingarchive.net/download/attachments/6884551/TCIA_Head-Neck_Cetuximab_06-22-2015.tcia?version=1&modificationDate=1534787422712&api=v2



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    labelSearch
    urlhttps://www.cancerimagingarchive.net/nbia-search/?CollectionCriteria=Head-Neck%20Cetuximab



    (Requires the NBIA Data Retriever .)

    DICOM Metadata Digest (CSV)
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    urlhttps://wiki.cancerimagingarchive.net/download/attachments/6884551/HeadNeckCetuximab_MetaData.csv?version=2&modificationDate=1495560309184&api=v2