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All the regions of interest (ROI) were drawn by Rajan Jain and Jayant Narang (Henry Ford Hospital) in consensus on the rCBV maps fused with post-contrast T1W images and FLAIR images. rCBV mean, rCBV max and rCBVNEL were measured from the rCBV maps and stored in a spreadsheet. For measuring rCBV mean ROI's were drawn on the contrast enhancing portion of the tumor (excluding any areas of necrosis and vessels) on all the slices which contained the tumor and a mean of these was obtained. For measuring rCBVmax an ROI of 10 x 10 voxels was placed on the hottest appearing part of the tumor based on the qualitative perfusion maps. An ROI of 10 x 10 voxels was placed on three spots on non-enhancing FLAIR abnormality within 1 cm of the edge of the enhancing lesion to measure rCBVNEL and obtain a mean.
This work was published in the following manuscript:
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Genomic Mapping and Survival Prediction in Glioblastoma: Molecular Subclassification Strengthened by Hemodynamic Imaging Biomarkers. |
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