Summary
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Finding better therapies for the treatment of brain tumors is hampered by the lack of consistently obtained molecular data in a large sample set and the ability to integrate biomedical data from disparate sources enabling translation of therapies from bench to bedside. Hence, a critical factor in the advancement of biomedical research and clinical translation is the ease with which data can be integrated, redistributed, and analyzed both within and across functional domains. Novel biomedical informatics infrastructure and tools are essential for developing individualized patient treatment based on the specific genomic signatures in each patient's tumor. The Repository of Molecular Brain Neoplasia Data (REMBRANDT) is aimed at facilitating discovery by connecting the dots between clinical information and genomic characterization data.
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REMBRANDT contains data generated through the Glioma Molecular Diagnostic Initiative from 874 glioma specimens comprising approximately 566 gene expression arrays, 834 copy number arrays, and 13,472 clinical phenotype data points. These data are currently housed in Georgetown University's G-DOC System and are described in a related manuscript . This image collection was created as a companion data set to augment the
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larger REMBRANDT project. It contains the pre-surgical magnetic resonance (MR) multi-sequence images
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For scientific inquiries about the VASARI feature set or corresponding analysis, please contact Adam Flanders at adam.flanders@jefferson.edu.
from 130 REMBRANDT patients.
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title | Data Access |
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| Data AccessChoosing the Download option will provide you with a file to launch the TCIA Download Manager to download the entire collection. If you want to browse or filter the data to select only specific scans/studies please use the Search By Collection option.
Data Type | Download all or Query/Filter |
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Images (DICOM, 9.9GB) | Image Removed Image Removed | Tcia button generator |
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url | https://wiki.cancerimagingarchive.net/download/attachments/3539229/TCIA_REMBRANDT_06-22-2015.tcia?version=1&modificationDate=1534787409774&api=v2 |
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label | Search |
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url | https://www.cancerimagingarchive.net/nbia-search/?CollectionCriteria=REMBRANDT |
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Download requires the NBIA Data Retriever. | Molecular/Clinical Data in G-DOC | Tcia button generator |
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ext | true |
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label | Search |
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url | https://gdoc.georgetown.edu/ |
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| Clinical Data (XLS) | Image Removed | Tcia button generator |
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url | https://wiki.cancerimagingarchive.net/download/attachments/3539229/clinical_2014-01-16.xlsx?version=2&modificationDate=1629237658680&api=v2 |
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| VASARI_MR_featurekey4 (pdf) | Image Removed | Tcia button generator |
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url | https://wiki.cancerimagingarchive.net/download/attachments/3539229/VASARI_MR_featurekey4.pdf?version=1&modificationDate=1319831391198&api=v2 |
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| VASARI_MRI_features (gmdi-wiki) (XLS) | Image Removed Tcia button generator |
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url | https://wiki.cancerimagingarchive.net/download/attachments/3539229/VASARI_MRI_features%20%28gmdi%20-%20wiki%29.xls?version=2&modificationDate=1366145660931&api=v2 |
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Click the Versions tab for more info about data releases. |
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title | Detailed Description |
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| Detailed Description
PatientsParticipants | 130 | Number of Studies | 174 | Number of Series | 1,483 | Number of Images | 110,020 | Image Size (GB) | 9.9 |
Clinical and Genomics DataA clinical data dump was exported from the publicly accessible section of the REMBRANDT Data Portal on 1/16/2014 for convenience to TCIA users. The old data portal has since been retired and all non-image data has been migrated to Georgetown University's G-DOC System . G-DOC contains The patients in TCIA can be matched by subject identifier with the extensive clinical, gene, and expression data of the same case available from the REMBRANDT Data Portalcases to research the link between radiological phenotype and tissue genotype. Registration is required. After logging in search for the REMBRANDT study to locate the data. The mapping table they provide within G-DOC is required to match TCIA's subject identifiers to the G-DOC identifiers. Radiologist AnalysesIn addition, there are imaging feature characterizations provided by neuroradiologists from Thomas Jefferson University (TJU) Hospital. This feature set has become known as "VASARI" and became the starting point for the The Cancer Genome Archive (TCGA) Glioma Phenotype Research Group efforts, which is utilizing data from the TCGA-GBM and TCGA-LGG collections. Clinical data set- Exported from the publicly accessible section of the REMBRANDT Data Portal on 1/16/2014 for convenience to TCIA users.
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title | Citations & Data Usage Policy |
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| Citations & Data Usage Policy This collection is freely available to browse, download, and use for commercial, scientific and educational purposes as outlined in the Creative Commons Attribution 3.0 Unported License. See TCIA's Data Usage Policies and Restrictions for additional details. Questions may be directed to help@cancerimagingarchive.net. Please be sure to include the following citations in your work if you use this data set: Public collection license |
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Info |
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| Scarpace, L., Flanders, A. E., Jain, R., Mikkelsen, T., & Andrews, D. W. (2019). Data From REMBRANDT [Data set]. The Cancer Imaging Archive. https://doi.org/10.7937/K9/TCIA.2015.588OZUZB | Info |
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| The Cancer Imaging Archive Team. Data From QIN-Breast. DOI is MISSING |
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| Clark, K., Vendt, B., Smith, K., Freymann, J., Kirby, J., Koppel, P., Moore, S., Phillips, S., Maffitt, D., Pringle, M., Tarbox, L., & Prior, F. (2013). The Cancer Imaging Archive (TCIA): Maintaining and Operating a Public Information Repository, . Journal of Digital Imaging, Volume 26, Number (6, December, 2013, pp 1045-1057. (paper)), 1045–1057. https://doi.org/10.1007/s10278-013-9622-7 |
Other Publications Using This DataTCIA maintains a list of publications which leverage our data. At this time we are not aware of any publications based on this data. If you have a publication you'd like to add please contact the TCIA Helpdesk. |
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| Version 1 (Current): 2(Current) 2021/08/17Some rows in the Clinical Data file were found to be misaligned per column headers: row 39,87,93,104: right shift by one (change within MRI findings or OnStudy Therapy Chemo Agent Name) row 46,57: right shift by 2 (change within MRI Findings) these realign CSV with no further adjustments made to content. Version 1 : Updated 2014/09/12
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