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| active | true |
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| title | Data Access |
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| Data Access
| Data Type | Download all or Query/Filter |
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CT Images (DICOM, 11.3 TB) |  This link downloads the entire collection, which is quite large, as legacy single frame images.
See the Detailed Description tab for options to download the collection in smaller chunks. 
(Download requires the NBIA Data Retriever) | Primary Tumor
Tissue Slide Images (SVS, 775 GB) | <link to browse NLST Pathology on caMicroscope coming soon> Additional images are available: See Detailed Description. (Download and apply the IBM-Aspera-Connect plugin to your browser) | | Clinical data (ZIP, 25 MB) |
(more info) Provided in SAS format in one compressed file (.zip);
includes data and dictionaries. This is a subset of the full clinical data. If you need the full clinical data,
please visit the Cancer Data Access System (CDAS) system. |
Click the Versions tab for more info about data releases. Please contact help@cancerimagingarchive.net with any questions regarding usage. |
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| title | Detailed Description |
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| Detailed DescriptionCollection Statistics | Radiology | Pathology |
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Modalities | CT (Legacy Single-Frame CT Images) | Aperio | Number of Patients | 26,254 | 451 | Number of Studies | 73,118 |
| Number of Series | 203,099 |
| Number of Images | 21,082,502 | 1,225 (optionally + 4 + 23) | | Images Size (GB) | 11.3 TB | 775 GB |
The pathology slide data: Primary Tumor slides (the standard package), 1225 files: <link to faspex package> caMicroscope User Guide for caMicroscope, the pathology viewer that provides researchers with an HTML5 based web client that can be used to view a digitized pathology image at full resolution. Users can zoom in/out, and pan across the image. caMicroscope also allows one to create annotations, save them and retrieve annotations that were previously drawn. - <link to NLST Pathology on caMicroscope coming soon>
Additional histopathology slide images <link to Table 1> for which the participants have no Baseline Questionnaire data (4 slides): <link to faspex package> Additional histopathology slide images <link to Table 2> for participants with Second Primary Tumors as well as those included in the "standard" package (23 slides): <link to faspex package>
Biospecimens CollectedFormalin-fixed paraffin embedded (FFPE) tissue specimens are available for a subset of the NLST participants who developed lung cancer during the trial. Donor blocks were obtained from local pathology laboratories and tissue cores (0.6mm) were extracted from them to construct tissue microarrays (TMA). Tissue cores were sampled from primary main invasive tumor histology, secondary tumor histology, carcinoma in situ, adjacent normal lung tissue, metastatic lesion from lymph node(s) and/or distant sites, benign (un-involved) lymph node, proximal and/or distal bronchi. In total, tissue materials were collected from 438 lung cancer cases. All have cores arrayed across nine TMAs, one of which only contains tissue collected after neoadjuvant treatment. 434 of these also have loose cores available for nucleic acid extraction. On average, each TMA contains 504 cores from 48 subjects. Applications for access to these specimens can be submitted under the PLCO Etiologic and Early Marker Studies Program (EEMS). The application review process opens twice a year, once in the winter and once in the summer. For more information about EEMS and to initiate an application visit the PLCO EEMS Application page. When filling out the application, specify “NLST Tissue” under the case definition. |
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| title | Citations & Data Usage Policy |
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| Citations & Data Usage Policy| Tcia license 4 international |
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| Info |
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| title | Publication Citation |
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| National Lung Screening Trial Research Team*; Aberle DR, Adams AM, Berg CD, Black WC, Clapp JD, Fagerstrom RM, Gareen IF, Gatsonis C, Marcus PM, Sicks JD (2011). Reduced Lung-Cancer Mortality with Low-Dose Computed Tomographic Screening. New England Journal of Medicine, 365(5), 395–409. https://doi.org/10.1056/nejmoa1102873
*note: List of National Lung Screening Trial members (pages 1-31 of this supplemental PDF to this article) |
| Info |
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| Clark K, Vendt B, Smith K, Freymann J, Kirby J, Koppel P, Moore S, Phillips S, Maffitt D, Pringle M, Tarbox L, Prior F. The Cancer Imaging Archive (TCIA): Maintaining and Operating a Public Information Repository, Journal of Digital Imaging, Volume 26, Number 6, December, 2013, pp 1045-1057. DOI: 10.1007/s10278-013-9622-7 |
Other Publications Using This DataTCIA maintains a list of publications which leverage TCIA data. If you have a manuscript you'd like to add please contact the TCIA Helpdesk. IMS/CDAS maintains a separate list of publications related to NLST data: https://cdas.cancer.gov/publications/?study=nlst |
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| Version 3 (Current) : Updated 2021/09/26| Data Type | Download all or Query/Filter |
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CT Images (DICOM, 11.3 TB) | (Download requires the NBIA Data Retriever) | | Tissue Slide Images (SVS, 775 GB) | | | Clinical data (ZIP, 25 MB) |
(more info) Provided in SAS format in one compressed file (.zip);
includes data and dictionaries,
other formats are available from IMS upon request. |
Data embargo of limited access is lifted September 2021, with the addition of (1) downloadable pathology slide data and (2) clinical data spreadsheet & dictionaries with no further restriction on number of participants per downloaded cohort. Version 2: Updated 2015/12/14| Data Type | Download all or Query/Filter |
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| Images (DICOM, 11.3TB) | |
Change: restoration of images that had become corrupted/missing during a storage transfer. Version 1: Updated 2013/03/01| Data Type | Download all or Query/Filter |
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| Images (DICOM, 11.3TB) | |
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