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Summary

Excerpt

The The Cancer Genome Atlas (TCGA) Head-Neck Phenotype Research Group is part of the Cancer Imaging ProgramProject TCGA Radiology Initiative; an effort to build a research community focused on analyzing images from the TCGA-Head and Neck Squamous Cell Carcinoma (HNSC) collection. Multiple modalities of images which correlate to the head-neck tissue data in the TCGA Data Portal are being gathered for submission to The Cancer Imaging Archive (TCIA).

According to the TCGA page on HNSC, researchers hope to make the following types of discoveries:

  • Determine whether patterns of genomic changes are different between tumors that metastasize to other regions of the body and tumors that remain in the region of origin.
  • Identify genomic differences that distinguish tumors across age and smoking history.
  • Identify genomic differences that are associated with viral infection.

...

connecting cancer phenotypes to genotypes by providing clinical images matched to tissue specimens analyzed for The Cancer Genome Atlas (TCGA).

Imaging Source Site (ISS) Groups are being formed and governed by participants from institutions that have provided imaging data to the archive for a given cancer type. Modeled after TCGA analysis groups, ISS groups are given the opportunity to publish a marker paper for a given cancer type per the guidelines in the table above. This opportunity will generate increased participation in building these multi-institutional data sets as they become an open community resource. Current TCGA-HNSC source sites include:

  • University of Pittsburgh (UPMC) (TSS code "-CN-")
  • University of North Carolina (TSS code "-BA-")
  • Vanderbilt (TSS code "-CR-")
  • MD Anderson (TSS code "-CV-")
  • Johns Hopkins University (TSS code "-BB-")

Please contact us at help@cancerimagingarchive.net if you have scientific questions or are interested in collaborating with their group.

Publications

TCGA Head-Neck Phenotype Research Group Publications

  • Manuscripts written by the group will be listed here as they are published.

Publications written by other members of the research community can be found on our TCIA Publications page.  Please contact us at help@cancerimagingarchive.net if you have a publication you would like us to add.

TCGA Genomics Publications

 Read the paper about the TCGA-HNSC genomic study in the journal Proceedings of the National Academy of Sciences.  Additional TCGA publications can be found at: http://cancergenome.nih.gov/publications.

Publication Policies

Per TCGA and TCIA Guidelines, formal permission requests are still no longer required to submit publications using TCGA-HNSC data.  Please see the following links for more information about the freedom-to-publish criteria for these data sets:

Data Source

Status

TCGA Data Portal Publication Guidelines

No restrictions; all data available without limitations.

TCIA Data Usage Policies and Restrictions

Projects have not reached 100 imaging cases; Please check with cancerimagingarchive@mail.nih.gov prior to any publication.No restrictions; all data available without limitations.

Please contact us at cancerimagingarchive@mailhelp@cancerimagingarchive.nih.govnet if you have any questions about these policies.

TCGA Head-Neck Marker Paper and Image Source Sites (ISS)

Imaging Source Site (ISS) Groups will be populated and governed by participants from institutions that have provided imaging data to the archive for a given cancer type. Modeled after TCGA analysis groups, ISS groups are given the opportunity to publish a marker paper for a given cancer type per TCGA Publication Guidelines. This opportunity will generate increased participation in building these multi-institutional data sets as they become an open community resource. Current TCGA-HNSC source sites include:

  • University of Pittsburgh / UPMC

This group has not yet been established. We will provide a point of contact for the group from the ISS site(s) as soon as possible to address scientific questions or requests to collaborate with their group.

References

The following links contain publications from the main TCGA project as well as their posted publication guidelines: