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Summary

Excerpt

This collection consists of magnetic resonance images (MRI) of genetically engineered mouse models (GEMMs) of breast cancer.  These images were acquired as part of a Department of Defense (DOD) Breast Cancer Research Program (BCRP) Postdoctoral Award W81XWH-12-1-0307 entitled “Investigating Ductal Carcinoma in Situ Using Noninvasive Imaging of Genetically Engineered Mouse Models

A particular emphasis of this project was to study the earliest stages of breast cancer—preinvasive ductal carcinoma in situ (DCIS)—and to interrogate the underlying genetic events that influence progression into invasive disease. In particular, we focused on the role of perturbed Rb, p53 and BRCA1 functionality and how these pathways, acting alone and in combination, can influence the development and progression of DCIS. GEMMs serve as an excellent model system wherein genetic changes can be controlled and manipulated over time.  In vivo MRI is a superb technique for noninvasively tracking and characterizing these microscopic early stage cancers as they develop, change and transition into lethal invasive disease.

For more information, please contact Dr. Sunny Jansen (jansensa0@gmail.com).

Acknowledgements

 We would like to acknowledge the individuals and institutions that have provided data for this collection:

  •  National Cancer Institute (Frederick, Maryland) - Special thanks to Sunny Jansen, PhD  from the Department of Mouse Cancer Genetics Program.

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Localtab Group
Localtab
activetrue
titleData Access

Data Access

Choosing the Download option will provide you with a file to launch the TCIA Download Manager to download the entire collection. If you want to browse or filter the data to select only specific scans/studies please use the Search By Collection option.

Data TypeDownload all or Query/Filter
Images (DICOM, 8.6GB) 

Click the Versions tab for more info about data releases.

Localtab
titleDetailed Description

Detailed Description

Collection Statistics

 

Modalities

MR

Number of Patients

32

Number of Studies

149

Number of Series

205

Number of Images

23,487

Images Size (GB)8.6

 

A presentation about a related Mouse GBM data set can be found at: Sunny_jansen_NBIA_mouseGBM_update_ICR_508.ppt.

Localtab
titleCitations & Data Usage Policy

Citations & Data Usage Policy 

This collection is freely available to browse, download, and use for commercial, scientific and educational purposes as outlined in the Creative Commons Attribution 3.0 Unported License.  See TCIA's Data Usage Policies and Restrictions for additional details. Questions may be directed to help@cancerimagingarchive.net.

Please be sure to include the following citations in your work if you use this data set:

Info
titleData Citation

Jansen, Sunny, Ileva, Lilia, Lu, Lucy, & Van Dyke, Terry. (2015). TCIA Mouse-Mammary Collection. The Cancer Imaging Archive. http://doi.org/10.7937/K9/TCIA.2015.9P42KSE6

Info
titleTCIA Citation

Clark K, Vendt B, Smith K, Freymann J, Kirby J, Koppel P, Moore S, Phillips S, Maffitt D, Pringle M, Tarbox L, Prior F. The Cancer Imaging Archive (TCIA): Maintaining and Operating a Public Information Repository, Journal of Digital Imaging, Volume 26, Number 6, December, 2013, pp 1045-1057. (paper)

Other Publications Using This Data

See the Publications page for papers about this data set. If you have a publication you'd like to add please contact the TCIA Helpdesk.

Localtab
titleVersions

Version 1 (Current): Updated 2015/03/18

Data TypeDownload all or Query/Filter
Images (8.6GB)