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Summary

 

Excerpt

Matched TCGA patient identifiers allow researchers to explore the TCGA/TCIA databases for correlations between tissue genotype, radiological phenotype and patient outcomes. Tissues for TCGA were collected from many sites all over the world in order to reach their accrual targets, usually around 500 specimens per cancer type. For this reason the image data sets are also extremely heterogeneous in terms of scanner modalities, manufacturers and acquisition protocols. In most cases the images were acquired as part of routine care and not as part of a controlled research study or clinical trial. 

CIP TCGA Radiology Initiative

Imaging Source Site (ISS) Groups are being populated and governed by participants from institutions that have provided imaging data to the archive for a given cancer type. Modeled after TCGA analysis groups, ISS groups are given the opportunity to publish a marker paper for a given cancer type per the guidelines in the table above. This opportunity will generate increased participation in building these multi-institutional data sets as they become an open community resource. Learn more about the TCGA Bladder Phenotype Research Group.

Acknowledgements

We would like to acknowledge the individuals and institutions that have provided data for this collection:

  • University of North Carolina- Special thanks to J. Keith Smith, M.D., Ph.D. and Shanah Kirk from the Department of Radiology. 
  • Barretos Cancer Hospital, Barretos, São Paulo, Brazil – Special Thanks to Fabiano Rubião Lucchesi, MD and Natália Del Angelo Aredes
  • University of Chicago- Special thanks to Nicholas Gruszauskas, Ph.D.
  • University of Sheffield - Special thanks to James Catto, MB, ChB, PhD, FRCS from the Department of Oncology.
  • Memorial Sloan-Kettering Cancer Center, New York, NY - Special thanks to Hebert A. Vargas Alvarez, MD and Pierre Elnajjar.
  • Lahey Hospital & Medical Center, Burlington, MA - Special thanks to John Lemmerman, RT and Kimberly Reiger-Christ, PhD, Cancer Research, Sophia Gordon Cancer Center.
  • University of Southern California- Special thanks to Siamak Daneshmand, MD, from the Department of Urology and Vinay Duddalwar, MD, FRCR from the Department of Radiology.

 

This collection consists of 251 CT scans of Credence Cartridge Radiomic (CCR) phantom. This texture phantom was developed to investigate the feature robustness in the emerging field of radiomics. This phantom dataset was acquired on 4-8 CT scanners using a set of imaging parameters (e.g., reconstruction Field of View, Slice thickness, reconstruction kernels, mAs, and Pitch). A controlled scanning approach was employed to assess the variability in radiomic features due to each imaging parameter. This dataset will be useful to radiomic research community to identify a subset of robust radiomic features and for establishing the ground truths for future clinical investigations.

This Phantom dataset can be used for Feature variability assessment due to CT imaging parameters. These phantom scans can be used to identify a subset of robust radiomic features for future clinical investigations. Using this dataset, the numerical values of radiomic features can be cross-validated by other research groups using their own feature extraction tools.

Acknowledgements

This dataset was submitted by Dr. Eduardo G. Moros and Dr. M Shafiq ul Hassan, USF. Special thanks to Moffitt Cancer Center where data were acquired.

Localtab Group


Click the Versions tab for more info about data releases.

Localtab
activetrue
titleData Access

Data Access

Choosing the Download option will provide you with a file to launch the TCIA Download Manager to download the entire collection. If you want to browse or filter the data to select only specific scans/studies please use the Search By Collection optionClick the  Download button to save a ".tcia" manifest file to your computer, which you must open with the NBIA Data Retriever . Click the Search button to open our Data Portal, where you can browse the data collection and/or download a subset of its contents.

Data TypeDownload all or Query/Filter
Images (DICOM,
40
30.
1GB
5GB)
 

Tissue Slide Images (web)

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GDC Data Portal - Clinical and Genomic Data

The GDC Data Portal has extensive clinical and genomic data, which can be matched to the patient identifiers on the images here in TCIA.  Below is a snapshot of clinical data extracted on 1/27/2016.

Explanations of the clinical data can be found on the Biospecimen Core Resource Clinical Data Forms linked below:

A Note about TCIA and TCGA Subject Identifiers and Dates

Subject Identifiers: a subject with radiology images stored in TCIA is identified with a Patient ID that is identical to the Patient ID of the same subject with demographic, clinical, pathological, and/or genomic data stored in TCGA. For each TCGA case, the baseline TCGA imaging studies found on TCIA are pre-surgical. 

Dates: TCIA and TCGA handle dates differently, and there are no immediate plans to reconcile:

  • TCIA Dates: dates (be they birth dates, imaging study dates, etc.) in the Digital Imaging and Communications in Medicine (DICOM) headers of TCIA radiology images have been offset by a random number of days. The offset is a number of days between 3 and 10 years prior to the real date that is consistent for each TCIA image-submitting site and collection, but that varies among sites and among collections from the same site. Thus, the number of days between a subject’s longitudinal imaging studies are accurately preserved when more than one study has been archived while still meeting HIPAA requirements.
  • TCGA Dates: the patient demographic and clinical event dates are all the number of days from the index date, which is the actual date of pathologic diagnosis. So all the dates in the data are relative negative or positive integers, except for the “days_to_pathologic_diagnosis” value, which is 0 – the index date. The years of birth and diagnosis are maintained in the distributed clinical data file. The NCI retains a copy of the data with complete dates, but those data are not made available.With regard to other TCGA dates, if a date comes from a HIPAA “covered entity’s” medical record, it is turned into the relative day count from the index date. Dates like the date TCGA received the specimen or when the TCGA case report form was filled out are not such covered dates, and they will appear as real dates (month, day, and year).
    Localtab
    titleDetailed Description

    Detailed Description

    Image Statistics

     


    Modalities

    CT

    , CR, MR, PT

    Number of

    Patients

    Participants

    106

    251

    Number of Studies

    135

    251

    Number of Series

    827

    251

    Number of Images

    78

    57,

    429

    839

    Images Size (GB)
    40.1
    30.5



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    Added 9 new subjects of imaging data.

    Version 5: Updated 2017/01/31

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    Added 6 new subjects of imaging data.

    Version 4: Updated 2016/08/31

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    Added 20 subjects' imaging data.

    Version 3: Updated 2016/05/31

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    Added 31 new subjects of imaging data.

    Version 2: Updated 2016/01/27

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    Extracted latest release of clinical data (TXT) from the GDC Data Portal.

    Version 1: Updated 2014/12/09
    1. Shafiq ul Hassan M, Latifi K, Zhang G, Ullah G, Gillies R and Moros E. (2018) Voxel size and gray level normalization of CT radiomic features in lung cancer patients. Scientific Reports.

    2. Shafiq ul Hassan M, Zhang G, Hunt D, Latifi K, Ullah G, Gillies R and Moros E, ‘Accounting for reconstruction kernel-induced variability in CT radiomic features using noise power spectra’, J. Med. Imag. 5(1), 011013 (2017). DOI: 10.1117/1.JMI.5.1.011013

    3. Shafiq ul Hassan M, Zhang G, Latifi K, Ullah G, Hunt D, Balagurunathan Y, Abdullah M, Schabath M, Goldgof D, Mackin D, Court L, Gillies R and Moros E. (2017) Intrinsic dependencies of CT radiomic features on voxel size and number of gray levels. Med. Phys. 44(3), p-1050-1062 .

    4. Paul R, Shafiq ul Hassan M, Moros E, Gillies R, Hall L, Goldgof D. (2018) Stability of deep features across CT scanners and Field Of View (FOV) using a physical phantom. Proc SPIE Medical Imaging Conference, February 2018, Texas, USA

    Localtab
    titleCitations & Data Usage Policy

    Citations & Data Usage Policy 

    TCGA collections have special publication embargoes which must be followed in addition to our normal data usage policies. See the TCGA section within TCIA's Data Usage Policies and Restrictions for additional details. After the publication embargo period ends these collections are freely available to browse, download, and use for commercial, scientific and educational purposes as outlined in the Creative Commons Attribution 3.0 Unported License. Questions may be directed to help@cancerimagingarchive.net. Please be sure to acknowledge both this data set and TCIA in publications by including the following citations in your work:
    Public collection license
    Info
    titleData Citation

    Kirk, S., Lee, Y., Lucchesi, F. R., Aredes, N. D., Gruszauskas, N., Catto, J., … Lemmerman, J. (2016). Radiology Data from The Cancer Genome Atlas Urothelial Bladder Carcinoma [TCGA-BLCA] collection. The Cancer Imaging Archive. Shafiq ul Hassan M, Zhang G, Latifi K, Ullah G, Gillies R, Moros E. Credence Cartridge Radiomics Phantom CT Scans with Controlled Scanning Approach. 2018. (DOI: http://doi.org/10.7937/K9/TCIA.2016.8LNG8XDR.2019.4l24tz5g


    Info
    titlePublication Citation

    Muhammad Shafiq ul Hassan, Geoffrey Zhang, Kujtim Latifi, Ghanim Ullah, Robert Gillies, Eduardo G. Moros. Computed Tomography Texture Phantom Dataset for Evaluating the Impact of CT Imaging Parameters on Radiomic Features. (link to paper)


    Info
    titleTCIA Citation

    Clark K, Vendt B, Smith K, Freymann J, Kirby J, Koppel P, Moore S, Phillips S, Maffitt D, Pringle M, Tarbox L, Prior F. The Cancer Imaging Archive (TCIA): Maintaining and Operating a Public Information Repository, Journal of Digital Imaging, Volume 26, Number 6, December, 2013, pp 1045-1057. (paper). DOI: 10.1007/s10278-013-9622-7

    Other Publications Using This Data

    TCIA maintains a list of publications which leverage our data. At this time we are not aware of any manuscripts based on this data. If you have a manuscript you'd like to add please contact the TCIA Helpdesk.

    Localtab
    titleVersions

    Version 6 (Current): Updated 2017/10/30

    Data TypeDownload all or Query/Filter
    Images (DICOM, 40.1GB)
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    Images (DICOM, 32.9GB)
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    Images (DICOM, 31.0GB)
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    Images (DICOM, 25.2GB)
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    Data TypeDownload all or Query/Filter
    Images (DICOM, 9.4GB)
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    Localtab
    titleVersions

    Version 1 (Current): 02-27-2019

    Data TypeDownload all or Query/Filter
    Images (DICOM,
    9
    30.
    4GB
    5GB)
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    Clinical Data (TXT)Image Removed
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