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The Cancer Genome Atlas Low Grade Glioma (TCGA-LGG) data collection is part of a larger effort to build a research community focused on connecting cancer phenotypes to genotypes by providing clinical images matched to subjects from The Cancer Genome Atlas (TCGA). Clinical, genetic, and pathological data resides in the Genomic Data Commons (GDC) Data Portal while the radiological data is stored on The Cancer Imaging Archive (TCIA).
Matched TCGA patient identifiers allow researchers to explore the TCGA/TCIA databases for correlations between tissue genotype, radiological phenotype and patient outcomes. Tissues for TCGA were collected from many sites all over the world in order to reach their accrual targets, usually around 500 specimens per cancer type. For this reason the image data sets are also extremely heterogeneous in terms of scanner modalities, manufacturers and acquisition protocols. In most cases the images were acquired as part of routine care and not as part of a controlled research study or clinical trial.
CIP TCGA Radiology Initiative
Imaging Source Site (ISS) Groups are being populated and governed by participants from institutions that have provided imaging data to the archive for a given cancer type. Modeled after TCGA analysis groups, ISS groups are given the opportunity to publish a marker paper for a given cancer type per the guidelines in the table above. This opportunity will generate increased participation in building these multi-institutional data sets as they become an open community resource. Learn more about the TCGA Glioma Phenotype Research Group.
We would like to acknowledge the individuals and institutions that have provided data for this collection:
- Thomas Jefferson University, Philadelpha, PA - Special thanks to Nancy Pedano and Adam E. Flanders, MD from the Department of Radiology, Jefferson Medical College.
- Henry Ford Hospital, Detroit, MI - Special thanks to Lisa Scarpace and Tom Mikkelsen, MD from the Department of Neurosurgery, Hermelin Brain Tumor Center.
- Saint Joseph Hospital and Medical Center, Phoenix, AZ - Special thanks to Jennifer M. Eschbacher, MD and Beth Hermes from the Department of Neuropathology/Pathology and to Victor Sisneros, PACS Administrator.
- Case Western Reserve University, Cleveland, OH -Special thanks to Jill Barnholtz, MD. and Quinn Ostrom.
- University of North Carolina, Chapel Hill, NC - Special thanks to J. Keith Smith, M.D.,Ph.D. and Shanah Kirk.