The Cancer Imaging Archive (TCIA) Public Access

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Background

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Driven by input from its scientific community, the Cancer Imaging Program (CIP) finds itself at the junction of two powerful scientific requisites; the need for cross-disciplinary research and inter-institutional data-sharing to speed scientific discovery and reduce redundancy, and the need to provide imaging phenotype data to augment large scale genomic analysis.

Image data collections on this archive offer an opportunity to encourage a new and emerging research community focused on connecting cancer phenotypes to genotypes by making available clinical images matched to the NIH TCGA (The Cancer Genome Atlas).  TCGA began in 2006 as a three-year pilot jointly sponsored by the National Cancer Institute and National Human Genome Research Institute. The TCGA pilot project (focused initially on glioblastoma, ovary, and lung cancers) confirmed that an atlas of genomic changes could be constructed for specific cancer types. It also showed that a national network of research and technology teams working on related projects could pool their efforts, create an economy of scale and develop an infrastructure for making the data publicly accessible. Importantly, it proved that making the data freely available would enable distributed researchers to make and validate important discoveries. The success of that pilot led the National Institutes of Health to commit major new resources to TCGA to collect and characterize more than 20 additional tumor types.

As an opportunity to leverage that wealth of new biomedical knowledge, CIP committed substantial effort to gather and place in The Cancer Imaging Archive the clinical diagnostic images that match the genomically analyzed TCGA tissue cases. CIP encouraged an ad hoc image research team to study glioblastoma. The Cancer Imaging Archive now contains a TCGA GBM collection with images from more than 150 cases whose molecular and clinical patient data can be accessed in the TCGA Data Portal.  A multi-institutional team coordinated by Dr Adam Flanders of Thomas Jefferson University assembled researchers from University of Virginia, Emory, Stanford, Henry Ford Hospital and NCI CCR have created the TCGA Glioma Phenotype Research Group.  In less than a year's time they have quickly demonstrated the advantages of such scientific collaboration by their rapid scientific progress with a number of publications and abstracts presented and in the pipeline for future venues.

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  • GBM - Glioblastoma multiforme (GBM) data is now available.  See the TCGA Glioma Phenotype Research Group wiki page for more information about starting new research projects or joining existing efforts.
  • LGG - Low grade glioma (LGG) data is now available.  See the TCGA Glioma Phenotype Research Group wiki page for more information about starting new research projects or joining existing efforts.
  • BRCA - Breast invasive carcinoma (BRCA) data is now available.  See the TCGA Breast Phenotype Research Group wiki page for more information about starting new research projects or joining existing efforts.
  • KIRC - Kidney renal clear cell carcinoma (KIRC) data is in the early stages of data collection.  In anticipation of this a TCGA Renal Phenotype Research Group wiki page has already been established and some preliminary research projects have already begun.

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