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Localtab Group


Localtab
activetrue
titleData Access

Data Access


Data TypeDownload all or Query/FilterLicense

CT Images (DICOM, 11.3 TB)


Tcia button generator
urlhttps://wiki.cancerimagingarchive.net/download/attachments/5800702/manifest-NLST_allCT.tcia?version=1&modificationDate=1633563007179&api=v2



Tcia button generator
labelSearch
urlhttps://nlst.cancerimagingarchive.net/nbia-search/


   

This link downloads the entire collection, which is quite large.
See the Detailed Description tab for options to download the collection in smaller chunks.

(Download requires the NBIA Data Retriever)


Tcia cc by 4

Primary Tumor
Tissue Slide Images (SVS, 775 GB)


Tcia button generator
urlhttps://faspex.cancerimagingarchive.net/aspera/faspex/external_deliveries/208?passcode=e89b6c607f2a8b50f76e06f1735c157357cdfdaf



Tcia button generator
labelSearch
urlhttps://pathdb.cancerimagingarchive.net/imagesearch?f[0]=collection:nlst



Additional images are available: See Detailed Description.

(Download and apply the IBM-Aspera-Connect plugin to your browser to retrieve this faspex package) 


Tcia cc by 4

Clinical data (ZIP, 25 MB)


Tcia button generator
urlhttps://wiki.cancerimagingarchive.net/download/attachments/5800702/package-nlst-780.2021-05-28.zip?version=1&modificationDate=1633562878492&api=v2



Provided in SAS format in one compressed file (.zip); 
includes data and dictionaries.

Tcia cc by 4

Click the Versions tab for more info about data releases.

Please contact help@cancerimagingarchive.net  with any questions regarding usage.

Nci_crdc additional resources

Additional Resources for this Dataset

The following external resources have been made available by the data submitters.  These are not hosted or supported by TCIA, but may be useful to the researchers utilizing this collection

This is a subset of the full clinical data.  If you need the full clinical data, please visit the Cancer Data Access System (CDAS) system.


Localtab
titleDetailed Description

Detailed Description

Collection Statistics

Radiology

Pathology

Modalities

 CT

Aperio

Number of Patients

 26,254

451

Number of Studies

73,118


Number of Series

203,099


Number of Images

21,082,502

1,225 (optionally + 4 + 23)
Images Size (TB)11.3 TB775 GB

The full CT data (manifest-NLST_allCT.tcia) occupy 11.3 terabytes when downloaded. For convenience, you can "Search" to access all the files, or you can download in chunks ordered only by Participant identifier (2,500 participants each):

  1. TCIA_NLST2500pid_01_20511series_888GB.tcia
  2. TCIA_NLST2500pid_02_20360series_878GB.tcia
  3. TCIA_NLST2500pid_03_20182series_868GB.tcia
  4. TCIA_NLST2500pid_04_20900series_899GB.tcia
  5. TCIA_NLST2500pid_05_20504series_891GB.tcia
  6. TCIA_NLST2500pid_06_18941series_820GB.tcia
  7. TCIA_NLST2500pid_07_20060series_957GB.tcia
  8. TCIA_NLST2500pid_08_17148series_1168GB.tcia
  9. TCIA_NLST2500pid_09_17064series_1172GB.tcia
  10. TCIA_NLST2500pid_10_17214series_1171GB.tcia
  11. TCIA_NLST_1254pid_11_8809series_600GB.tcia

The pathology slide data: 

  1. Primary Tumor slides (faspex) Primary Tumor slides (the standard package), 1225 files.

  2. Additional slides (faspex) Additional histopathology slide images for which the participants have no Baseline Questionnaire data (4 slides) Detail in Table 1.

  3. Second Primary-Tumor slides (faspex) Additional histopathology slide images for participants with Second Primary Tumors as well as those included in the "standard" package (23 slides) Detail in Table 2

NLST Design & Process, Protocol Documents, and Results: https://cdas.cancer.gov/learn/nlst/main-findings/

NLST Data Collected: https://biometry.nci.nih.gov/cdas/learn/nlst/data-collected/

  • Questionnaires, screening, diagnostic procedures, cancer diagnosis, treatment, progression, mortality, contamination.

Biospecimens Collected

Formalin-fixed paraffin embedded (FFPE) tissue specimens are available for a subset of the NLST participants who developed lung cancer during the trial. Donor blocks were obtained from local pathology laboratories and tissue cores (0.6mm) were extracted from them to construct tissue microarrays (TMA). Tissue cores were sampled from primary main invasive tumor histology, secondary tumor histology, carcinoma in situ, adjacent normal lung tissue, metastatic lesion from lymph node(s) and/or distant sites, benign (un-involved) lymph node, proximal and/or distal bronchi.

In total, tissue materials were collected from 438 lung cancer cases. All have cores arrayed across nine TMAs, one of which only contains tissue collected after neoadjuvant treatment. 434 of these also have loose cores available for nucleic acid extraction. On average, each TMA contains 504 cores from 48 subjects.

Applications for access to these specimens can be submitted under the PLCO Etiologic and Early Marker Studies Program (EEMS). The application review process opens twice a year, once in the winter and once in the summer. For more information about EEMS and to initiate an application visit the PLCO EEMS Application page. When filling out the application, specify “NLST Tissue” under the case definition.



Localtab
titleCitations & Data Usage Policy

Citations & Data Usage Policy 

Tcia limited license policy

Info
titleDataset Citation

 National Lung Screening Trial Research Team. (2013). Data from the National Lung Screening Trial (NLST) [Data set]. The Cancer Imaging Archive. https://doi.org/10.7937/TCIA.HMQ8-J677


Info
titlePublication Citation

National Lung Screening Trial Research Team*; Aberle DR, Adams AM, Berg CD, Black WC, Clapp JD, Fagerstrom RM, Gareen IF, Gatsonis C, Marcus PM, Sicks JD (2011). Reduced Lung-Cancer Mortality with Low-Dose Computed Tomographic Screening. New England Journal of Medicine, 365(5), 395–409. https://doi.org/10.1056/nejmoa1102873


*note:  List of National Lung Screening Trial members (pages 1-31 of this supplemental PDF to this article)


Info
titleTCIA Citation

Clark K, Vendt B, Smith K, Freymann J, Kirby J, Koppel P, Moore S, Phillips S, Maffitt D, Pringle M, Tarbox L, Prior F. The Cancer Imaging Archive (TCIA): Maintaining and Operating a Public Information Repository, Journal of Digital Imaging, Volume 26, Number 6, December, 2013, pp 1045-1057. DOI: https://doi.org/10.1007/s10278-013-9622-7

Other Publications Using This Data

TCIA maintains a list of publications which leverage TCIA data. If you have a manuscript you'd like to add please contact the TCIA Helpdesk.

IMS/CDAS maintains a separate list of publications related to NLST data: https://cdas.cancer.gov/publications/?study=nlst 


Localtab
titleVersions

Version 3 (Current) : Updated 2021/09/24

Data TypeDownload all or Query/Filter

CT Images (DICOM, 11.3 TB)


Tcia button generator
urlhttps://wiki.cancerimagingarchive.net/download/attachments/5800702/manifest-NLST_allCT.tcia?version=1&modificationDate=1633563007179&api=v2



Tcia button generator
labelSearch
urlhttps://nlst.cancerimagingarchive.net/nbia-search/


   

This link downloads the entire collection, which is quite large, as legacy single frame images.
See the Detailed Description tab for options to download the collection in smaller chunks.


(Download requires the NBIA Data Retriever)

Primary Tumor
Tissue Slide Images (SVS, 775 GB)


Tcia button generator
urlhttps://faspex.cancerimagingarchive.net/aspera/faspex/external_deliveries/208?passcode=e89b6c607f2a8b50f76e06f1735c157357cdfdaf



Tcia button generator
labelSearch
urlhttps://pathdb.cancerimagingarchive.net/imagesearch?f[0]=collection:nlst



Additional images are available: See Detailed Description.

(Download and apply the IBM-Aspera-Connect plugin to your browser to retrieve this faspex package) 

Clinical data (ZIP, 25 MB)


Tcia button generator
urlhttps://wiki.cancerimagingarchive.net/download/attachments/5800702/package-nlst-780.2021-05-28.zip?version=1&modificationDate=1633562878492&api=v2



(more info)  

Provided in SAS format in one compressed file (.zip); 
includes data and dictionaries.

This is a subset of the full clinical data.  If you need the full clinical data,
please visit the Cancer Data Access System (CDAS) system.



Data embargo of limited access is lifted September 2021, with the addition of downloadable pathology slide data and clinical data spreadsheet & dictionaries.

Version 2: Updated 2015/12/14

Data TypeDownload all or Query/Filter
Images (DICOM, 11.3TB)


Tcia button generator
labelSearch
urlhttps://queries.cancerimagingarchive.net/NLSTQueryTool/faces/main.xhtml



Change: restoration of images that had become corrupted/missing during a storage transfer.

Version 1 (Current): Updated 2013/03/01

Data TypeDownload all or Query/Filter
Images (DICOM, 11.3TB)


Tcia button generator
labelSearch
urlhttps://queries.cancerimagingarchive.net/NLSTQueryTool/faces/main.xhtml





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