Summary

According to the TCGA page on lung adenocarcinoma, researchers hope to make the following types of discoveries about lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC):

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Per TCGA and TCIA Guidelines formal permission requests are still required to submit publications using TCGA-LUAD data.  Please see the following links for more information about the freedom-to-publish criteria for these data sets:

Please contact us at cancerimagingarchive@mail.nih.gov if you have any questions about these policies, or would like to join our public mailing list and be kept in the loop about new data releases and other related news as this effort moves forward.

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• TCGA Publications
• TCGA Publication Guidelines

In addition, this section contains papers, presentations, and videos from the genomics/clinical perspectives which may be of interest to TCGA-LUAD researchers.

• Li, Y., Zhang, L., Ball, R.L., Liang, X., Li, J., Lin, Z. and Liang, H. (2012) Comparative analysis of somatic copy-number alterations across different human cancer types reveals two distinct classes of breakpoint hotspots. Hum Mol Genet. 21(22):4957-4965. View PubMed abstract
• Sproul, D., Kitchen, R.R., Nestor, C.E., Dixon, J.M., Sims, A.H., Harrison, D.J., Ramsahoye, B.H. and Meehan, R.R. (2012) Tissue of origin determines cancer-associated CpG island promoter hypermethylation patterns. Genome Biol. 13(10):R84. Read the full article
• Greulich, H., Kaplan, B., Mertins, P., Chen, T.H., Tanaka, K.E. Yun, C.H., Zhang, X., Lee, S.H., Cho, J., Ambrogio, L., et al. (2012) Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2. Proc Natl Acad Sci U S A. 109(36):14476-14481. View PubMed abstract
• Liu, P., Morrison, C., Wang, L., Xiong, D., Vedell, P., Cui, P., Hua, X., Ding, F., Lu, Y., James M, et al. (2012) Identification of somatic mutations in non-small cell lung carcinomas using whole-exome sequencing. Carcinogenesis. 33(7):1270-1276 . View PubMed abstract
• Shinjo, K., Okamoto, Y., An, B., Yokoyama, T., Takeuchi, I., Fujii, M., Osada, H., Usami, N., Hasegawa, Y., Ito, H., et al. (2012) Integrated analysis of genetic and epigenetic alterations reveals CpG island methylator phenotype associated with distinct clinical characters of lung adenocarcinoma. Carcinogenesis. 33(7):1277-1285. View PubMed abstract
• Andreopoulos, B. and Anastassiou, D. (2012) Integrated analysis reveals hsa-miR-142 as a representative of a lymphocyte-specific gene expression and methylation signature. Cancer Inform. 11 61-75. Read the full article
• Zhuang, J., Jones, A., Lee, S.-H., Ng, E., Fiegl, H., Zikan, M., Cibula, D., Sargent, A., Salvesen, H., Jacobs, I.J., et al. (2012) The dynamics and prognostic potential of DNA methylation changes at stem cell gene loci in women's cancer. PLoS Genet. 8(2):e1002517. Read the full article
• Yao, C., Li, H., Shen, X., He, Z., He, L. and Guo, Z. (2012) Reproducibility and concordance of differential DNA methylation and gene expression in cancer. PLoS One. 7(1):e29686. Read the full article
• Lin, K., Taylor, J.R. Jr., Wu, T.D., Gutierrez, J., Elliott, J.M., Vernes, J.M., Koeppen, H., Phillips, H.S., de Sauvage, F.J. and Meng, Y.G. (2011) TMEFF2 is a PDGF-AA binding protein with methylation-associated gene silencing in multiple cancer types including glioma. PLoS One. 6(4):e18608. Read the full article

TCGA 2nd Annual Symposium

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