Summary
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For kidney cancer, TCGA will create a reference genome, against which new patients will be compared, for both clear cell and papillary cancer types. The initial objectives of TCGA for kidney cancer are, according to the NIH:
- Identify unique patterns of genomic changes that divide clear cell and papillary carcinoma tumors into subgroups
- Identify genomic differences that distinguish tumors across gender, race or ethnicity
- Determine if specific patterns of genomic changes are connected to tumor recurrence after therapy
Starting or Joining a Research Project
Research and Publications
Per TCGA and TCIA Guidelines formal permission requests are still required to submit publications using TCGA-KIRC data. Please see the following links for more information about the freedom-to-publish criteria for these data sets:
We are currently hosting calls in support of TCGA renal based research projects (TCGA-KIRC) on Fridays at 1pm Eastern. Please contact us at cancerimagingarchive@mail.nih.gov if you have any questions about these policies, or would like to inquire about setting up a new research project, discuss potential collaborations with existing groups or be otherwise join our public mailing list and be kept in the loop about new data releases and other related news as this effort moves forward.
Group Projects
This is a listing of ongoing projects. If you are working with the TCGA glioma data hosted on TCIA please let us know and we would be happy to add a section describing your project here.
- Renal Image Feature Scoring Project - This project is in the preliminary stages and is being collaborated on by group members from MSKCC, MDACC, and UPMC. Multiple readers are evaluating each subject's imaging features using a consensus driven Renal Feature Key and then investigating potential correlations with the TCGA genomic and clinical data.
Publications
TCGA-KIRC Marker Paper and Image Source Sites (ISS)
Imaging Source Site (ISS) Groups will be populated and governed by participants from institutions that have provided imaging data to the archive for a given cancer type. Modeled after TCGA analysis groups, these groups are given the opportunity to publish a marker paper for a given cancer type per the aforementioned publication policy. It is hoped that this will generate increased participation in the building of these multi-institutional data sets that become an open community resource. Current TCGA-KIRCsource sites include:
- Memorial Sloan-Kettering Cancer Center
- University of Pittsburgh / UPMC
References
The There are currently no imaging based publications for TCGA-KIRC or TCGA-KIRP. However, the following links contain publications from the main TCGA project, as well as their posted publication guidelines.
References
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2nd Annual TCGA Symposium
- Adverse Outcomes in Clear Cell Renal Cell Carcinoma With Mutations of 3p21 Epigenetic Regulators BAP1 and SETD2
- TCGA Clear Cell Renal Cell Carcinoma Project
Other Publications
- Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. Gerlinger M, Rowan AJ, Horswell S, Larkin J, Endesfelder D, Gronroos E, Martinez P, Matthews N, Stewart A, Tarpey P, Varela I, Phillimore B, Begum S, McDonald NQ, Butler A, Jones D, Raine K, Latimer C, Santos CR, Nohadani M, Eklund AC, Spencer-Dene B, Clark G, Pickering L, Stamp G, Gore M, Szallasi Z, Downward J, Futreal PA, Swanton C.N Engl J Med. 2012 Mar 8;366(10):883-92. doi: 10.1056/NEJMoa1113205. Erratum in: N Engl J Med. 2012 Sep 6;367(10):976.