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The Cancer Genome Atlas (TCGA) Ovarian Phenotype Research Group is part of the Cancer Imaging Project TCGA Radiology Initiative; an effort to build a research community focused on analyzing images from the TCGA-ovarian (OV) collections. Images which correlate to the ovarian serous cystadenocarcinoma (OSC) tissue data in TCGA’s Data Portal are being gathered for submission to The Cancer Imaging Archive (TCIA).

According to the TCGA page on OSC, TCGA researchers have:

  • Confirmed that mutations in gene TP53 are present in more than 96 percent of ovarian cases. The TP53 gene encodes a tumor suppressor protein that normally prevents cancer development.
  • Analyzed gene expression patterns and found signatures that correlate with poor or better survival. Patients whose tumors showed a gene expression pattern associated with poor survival lived a period 23 percent shorter than patients without that signature.
  • Affirmed the existence of four distinct subtypes of ovarian cancer through examination of RNA transcription and DNA methylation patterns.
  • Observed that patients with mutations in their BRCA1 and BRCA2 genes have better odds of survival than patients without mutations in those genes. Approximately 21 percent of tumor cases in this study exhibited BRCA1 and BRCA2 mutations.
  • Identified therapeutic opportunities by searching for existing drugs that might correct a genomic error that causes a patient's ovarian cancer. The search yielded 68 genes that could be targeted by existing Food and Drug Administration-approved or experimental therapeutic compounds.

Research and Publications

Per TCGA and TCIA Guidelines, formal permission requests are still required to submit publications using TCGA-OV data.  Please see the following links for more information about the freedom-to-publish criteria for these data sets:

Data Source

Status

TCGA Data Portal Publication Guidelines

No restrictions; all data available without limitations.

TCIA Data Usage Policies and Restrictions

Publication limitations in place until 8/15/2015; please check with help@cancerimagingarchive.net prior to any publication

Please contact us at help@cancerimagingarchive.net if you have any questions about these policies.

TCGA-OV Marker Paper and Image Source Sites (ISS)

connecting cancer phenotypes to genotypes by providing clinical images matched to tissue specimens analyzed for The Cancer Genome Atlas (TCGA).

Imaging Source Site (ISS) Groups will be populated are being formed and governed by participants from institutions that have provided imaging data to the archive for a given cancer type. Modeled after TCGA analysis groups, ISS groups are given the opportunity to publish a marker paper for a given cancer type per the guidelines in the table above. This opportunity will generate increased participation in building these multi-institutional data sets as they become an open community resource. Current  Current TCGA-OV source  source sites include:

  • Washington University St. Louis
  • MSKCC
  • UPMC
  • MDACC
  • UNC

Please contact Dr. Evis Sala (salae@mskccsalae@mskcc.org) if you have scientific questions for TCGA-OV ISS, or are interested in collaborating with their group.

References

The following links contain publications from the main TCGA project as well as their posted publication guidelines:

Publications

TCGA Ovarian Phenotype Research Group Publications

  • Manuscripts written by the group will be listed here as they are published.

Publications written by other members of the research community can be found on our TCIA Publications page.  Please contact us at help@cancerimagingarchive.net if you have a publication you would like us to add.

TCGA Genomics Publications

 Read about the TCGA-OV genomic study.  Additional TCGA publications can be found at: http://cancergenome.nih.gov/publications.

Publication Policies

 

Per TCGA and TCIA Guidelines, formal permission requests are no longer required to submit publications using TCGA-OV data.  Please see the following links for more information about the freedom-to-publish criteria for these data sets:

 

Data Source

Status

TCGA Data Portal Publication Guidelines

No restrictions; all data available without limitations.

TCIA Data Usage Policies and Restrictions

No restrictions; all data available without limitations.

 

Please contact us at help@cancerimagingarchive.net if you have any questions about these policies.