Summary
This collection consists of magnetic resonance images (MRI) of genetically engineered mouse models (GEMMs) of breast cancer. These images were acquired as part of a Department of Defense (DOD) Breast Cancer Research Program (BCRP) Postdoctoral Award W81XWH-12-1-0307 entitled “Investigating Ductal Carcinoma in Situ Using Noninvasive Imaging of Genetically Engineered Mouse ModelsA particular emphasis of this project was to study the earliest stages of breast cancer—preinvasive ductal carcinoma in situ (DCIS)—and to interrogate the underlying genetic events that influence progression into invasive disease. In particular, we focused on the role of perturbed Rb, p53 and BRCA1 functionality and how these pathways, acting alone and in combination, can influence the development and progression of DCIS. GEMMs serve as an excellent model system wherein genetic changes can be controlled and manipulated over time. In vivo MRI is a superb technique for noninvasively tracking and characterizing these microscopic early stage cancers as they develop, change and transition into lethal invasive disease.
For more information, please contact Dr. Sunny Jansen (jansensa0@gmail.com).
References
- Jansen SA et al, NMR Biomed. 2011 Aug;24(7):880-7.
- Jansen SA et al, Breast Cancer Res. 2009;11(5):R65.
- Jansen SA et al, Radiology. 2009 Nov;253(2):399-406.
- Jansen SA et al, Phys Med Biol. 2008 Oct 7;53(19):5481-93.
- DOD Award: http://oai.dtic.mil/oai/oai?verb=getRecord&metadataPrefix=html&identifier=ADA585341.
Data Access
Imaging Data
You can view and download these images on TCIA by clicking and selecting the Mouse-Mammary collection.
Collection Statistics | (updated 2015/03/18) |
|---|---|
Modalities | MR |
Number of Patients | 32 |
Number of Studies | 149 |
Number of Series | 205 |
Number of Images | 23,487 |
| Images Size (GB) | 8.6 |
If you are unsure how to download this collection, please view Searching by Collection or refer to TCIA's User's Guide for more detailed instructions on using the site.
Related Data
Mouse GBM: A Pilot Collection: Sunny_jansen_NBIA_mouseGBM_update_ICR_508.ppt .
Acknowledgements
We would like to acknowledge the individuals and institutions that have provided data for this collection:
- National Cancer Institute (Frederick, Maryland) - Special thanks to Sunny Jansen, PhD from the Department of Mouse Cancer Genetics Program.
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