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The TCGA Renal Phenotype Research Group is part of the CIP TCGA Radiology Initiative focused on analyzing images from the TCGA-KIRC collection. Multiple modalities of images which correlate to the kidney renal clear cell carcinoma (KIRC) data in the TCGA Data Portal are currently being gathered for submission to TCIA. In the mean time the group is beginning preliminary discussions around research methods and goals.

For kidney cancer, TCGA will create a reference genome, against which new patients will be compared, for both clear cell and papillary cancer types. The initial objectives of TCGA for kidney cancer are, according to the NIH:

  • Identify unique patterns of genomic changes that divide clear cell and papillary carcinoma tumors into subgroups
  • Identify genomic differences that distinguish tumors across gender, race or ethnicity
  • Determine if specific patterns of genomic changes are connected to tumor recurrence after therapy

Starting or Joining a Research Project

We are currently hosting calls in support of TCGA renal based research projects (TCGA-KIRC) on Fridays at 1pm Eastern. Please contact us at if you would like to inquire about setting up a new research project, discuss potential collaborations with existing groups or be otherwise kept in the loop as this effort moves forward.

Group Projects

This is a listing of ongoing projects.  If you are working with the TCGA glioma data hosted on TCIA please let us know and we would be happy to add a section describing your project here.

  • Renal Image Feature Scoring Project - This project is in the preliminary stages and is being collaborated on by group members from MSKCC, MDACC, and UPMC. Multiple readers are evaluating each subject's imaging features using a consensus driven Renal Feature Key and then investigating potential correlations with the TCGA genomic and clinical data.


There are currently no imaging based publications for TCGA-KIRC or TCGA-KIRP. However, the following links contain publications from the main TCGA project, as well as their posted publication guidelines.


This section contains papers, presentations, and videos from the genomics/clinical perspectives which may be of interest to the renal imaging group.

2nd Annual TCGA Symposium

  • Adverse Outcomes in Clear Cell Renal Cell Carcinoma With Mutations of 3p21 Epigenetic Regulators BAP1 and SETD2
    • Ari Hakimi, MD, Memorial Sloan-Kettering Cancer Center
    • Video | Slides
  • TCGA Clear Cell Renal Cell Carcinoma Project
    • Chad J. Creighton, PhD, Baylor College of Medicine
    • Video | Slides
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