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Table A. Distribution of study population demographics and imaging parameters by imaging biomarkers in Cohort 2.

 

 

Imaging biomarkers

 

Characteristic 1

 

Entropy ratio

Tumor volume

Convexity

No.

(%)

Mean

(SD)

Mean

(SD)

Mean

(SD)

 

 

 

 

 

 

 

 

 

Overall

47

(100)

1.27

(0.16)

1,576,573

(5,538,671) 

0.86

(0.07)

 

 

 

 

 

 

 

 

 

Demographics

 

 

 

 

 

 

 

 

 

Age at diagnosis

 

 

 

 

 

 

 

 

 

< 65

19

(40.4)

1.29

(0.17)

1,600,656

(5,324,588) 

0.86

(0.06)

 

≥ 65

28

(59.6)

1.27

(0.16)

1,560,231

(5,776,054)

0.87

(0.08)

P-value

 

 

0.697

0.981

0.725

 

 

 

 

 

 

 

 

 

 

Gender

 

 

 

 

 

 

 

 

 

Female

22

( 46.8 )

1.27

(0 .17 )

1,673,242

( 6,449,505 )  

0.87

(0 .07 )

 

Male

25

( 53.2 )

1.28

(0 .16 )

1,491,504

( 4,731,241 )

0.87

0( .07 )

P-value

 

 

0.847

0.912

0.947

 

 

 

 

 

 

 

 

 

 

Stage 1

 

 

 

 

 

 

 

 

 

Stage I

10

(21.7)

1.21

(0.13)

87,739

(150,848)

0.89

(0.04)

 

Stage II

21

(54.7)

1.35

  (0.18)

385,901

(675,387) 

0.89

(0.05)

 

Stages III and IV

15

(32.6)

1.23

(0.13)

4,340,499

(9,383,981)

0.82

(0.09)

P-value

 

 

0.017

0.067

0.002

 

 

 

 

 

 

 

 

 

Imaging Parameters

 

 

 

 

 

 

 

 

 

Voltage, KvP

 

 

 

 

 

 

 

 

 

120

40

(85.1)

1.27

(0.16)

1,046,870

(3,786,242)

0.87

(0.07)

 

130 or 140

7

(14.9)

1.27

(0.17)

4,603,446

(1.14e+07)

0.86

(0.09)

P-value

 

 

0.954

0.118

0.761

 

 

 

 

 

 

 

 

 

 

Convolution kernel

 

 

 

 

 

 

 

 

 

A, B

23

(48.9)

1.27

(0.13)

1,486,610

(4,834,356)

0.86

(0.07)

 

B30s ,B60f, B70s

5

(10.6)

1.15

(0.04)

6,194,466

(1,3532,86)

0.85

(0.10)

 

B40f

15

(31.9)

1.28

(0.18)

478,889

(1,556,613)

0.88

(0.06)

 

Other

4

(8.5)

1.47

(0.19)

437,803

(376,848)

0.88

(0.06)

P-value

 

 

0.026

0.240

0.740

 

 

 

 

 

 

 

 

 

 

Slice thickness, mm

 

 

 

 

 

 

 

 

 

<5.0

18

(38.3)

1.25

(0.17)

3350,823

(8,667,079)

0.85

(0.09)

 

≥ 5.0

29

(61.7)

1.29

(0.16)

475,314

(1,228,994)

0.88

(0.06)

P-value

 

 

0.345

0.084

0.161

 

 

 

 

 

 

 

 

 

 

Pixel resolution 4 , mm

 

 

 

 

 

 

 

 

 

< 0.9547

15

(31.9)

1.30

(0.18)

2627,460

(7,726,859)

0.86

(0.07)

 

≥ 0.9547 to < 0.9766 

19

(40.4)

1.26

(0.17)

417,926

(1,384,700)

0.88

(0.07)

 

≥ 0.9766 

13

(27.7)

1.26

(0.14)

2,057,416

(6,427,053)

0.86

(0.08)

P-value

 

 

0.672

0.489

0.652

 

 

 

 

 

 

 

 

 

1 Stage was missing for 1 patient

 

Table B. Concordance correlation coefficient (CCC) and dynamic range for CT features in the test-retest experiment, averages over tumor volume.

Feature

Metrics to Test Repeatability

Absolute Percent

Difference (|Test-Retest|)

statistics (µ , σ)

CCC

DR

Convexity

0.887667

0.924985

(3.77%, 4.19)

Entropy of tumor core

0.894919

0.944633

(1.68%, 2.04)

Entropy of tumor boundary

0.816676

0.927453

(1.95%,2.69)

Entropy Ratio

0.356657

0.914966

(1.69%,2.58)

 

 

Table C. Feature Reproducibility in test-retest analyses using matching center slice on the CT image.

Feature

CCC

DR

Convexity

0.989043

0.971538

Entropy of tumor core

0.992352

0.968886

Entropy of tumor boundary

0.992078

0.968946

Entropy Ratio

0.997684

0.987559

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Table D. Clinical parameters and feature scores for Cohort 1 patients.

Patient Identifier

TNM Pathology

Vital Status

 

Survival Time

(months)

Convexity

Score

Entropy Ratio Score

Patient_004

2B

1 (ALIVE)

44

0.895941

1.637799599

Patient_006

1A

1 (ALIVE)

34

0.892942

2.051510628

Patient_013

1B

1 (ALIVE)

50

0.80782

1.273299753

Patient_014

1A

1 (ALIVE)

25

0.940532

1.505925886

Patient_019

1A

0 (DEAD)

3

0.860215

1.476915543

Patient_020

N/A

0 (DEAD)

7

0.936766

1.450419311

Patient_022

2B

0 (DEAD)

15

0.852905

1.350108967

Patient_029

N/A

0 (DEAD)

10

0.787763

1.389544112

Patient_033

2A

0 (DEAD)

9

0.855026

1.145383741

Patient_035

3B

1 (ALIVE)

40

0.965196

1.333453072

Patient_036

1B

0 (DEAD)

18

0.876594

1.421216574

Patient_043

3A

1 (ALIVE)

24

0.745247

1.185617798

Patient_053

2B

0 (DEAD)

28

0.56621

1.539657174

Patient_056

4

1 (ALIVE)

46

0.855807

0.923998156

Patient_061

1A

1 (ALIVE)

31

0.820135

1.003796846

Patient_064

2B

1 (ALIVE)

53

0.897708

1.293024652

Patient_065

3A

0 (DEAD)

12

0.875437

1.514122013

Patient_066

3B

0 (DEAD)

16

0.877111

1.517057645

Patient_069

2B

0 (DEAD)

20

0.805064

1.892848603

Patient_075

1B

1 (ALIVE)

29

0.917354

1.589426464

Patient_077

1A

1 (ALIVE)

48

0.927001

1.057481677

Patient_078

1A

1 (ALIVE)

36

0.91025

1.081908218

Patient_093

3A

1 (ALIVE)

39

0.973508

1.437448628

Patient_098

3A

0 (DEAD)

10

0.791397

1.233049848

Patient_102

2B

1 (ALIVE)

52

0.918841

1.175298586

Patient_108

3A

0 (DEAD)

15

0.939503

1.494887372

Patient_111

2B

1 (ALIVE)

31

0.88193

1.51369054

Patient_116

1A

1 (ALIVE)

24

0.666667

1.244652643

Patient_117

N/A

0 (DEAD)

9

0.790491

1.033623124

Patient_124

1A

1 (ALIVE)

39

0.897516

1.033843648

Patient_126

3B

0 (DEAD)

7

0.889436

1.552041887

Patient_127

3A

0 (DEAD)

8

0.846932

1.434631129

Patient_137

3A

1 (ALIVE)

9

0.9411

1.415481918

Patient_141

2B

1 (ALIVE)

6

0.864421

1.505524832

Patient_143

1A

1 (ALIVE)

59

0.898634

1.401262263

Patient_144

2B

0 (DEAD)

10

0.958028

1.746048258

Patient_146

2B

1 (ALIVE)

71

0.913239

1.32634188

Patient_150

1A

1 (ALIVE)

44

0.899007

1.229961722

Patient_157

3A

0 (DEAD)

12

0.89019

1.406529718

Patient_168

3A

1 (ALIVE)

9

0.890522

2.188790964

Patient_170

1A

0 (DEAD)

18

0.893387

1.40040846

Patient_172

2B

1 (ALIVE)

40

0.778899

1.11975251

Patient_175

2A

0 (DEAD)

23

0.942142

1.523694504

Patient_180

1A

1 (ALIVE)

48

0.894826

1.36175218

Patient_185

3A

1 (ALIVE)

32

0.889856

1.345810989

Patient_191

3A

0 (DEAD)

13

0.87234

1.578902125

Patient_193

1B

0 (DEAD)

28

0.67382

1.26032436

Patient_208

2A

1 (ALIVE)

35

0.916822

1.47792144

Patient_209

1B

1 (ALIVE)

27

0.885131

1.843202606

Patient_210

2B

1 (ALIVE)

34

0.845553

1.613904366

Patient_214

2B

0 (DEAD)

17

0.889868

1.620078459

Patient_232

1A

1 (ALIVE)

30

0.908654

1.712589592

Patient_233

1A

1 (ALIVE)

29

0.907859

1.73328033

Patient_237

1A

1 (ALIVE)

42

0.89646

1.182347065

Patient_239

2B

0 (DEAD)

36

0.752475

1.06587384

Patient_256

3B

1 (ALIVE)

54

0.732521

1.366254758

Patient_259

2B

1 (ALIVE)

59

0.84766

1.137637745

Patient_260

1B

0 (DEAD)

17

0.900088

1.288138825

Patient_266

2A

1 (ALIVE)

51

0.927613

1.745517414

Patient_267

1B

1 (ALIVE)

51

0.8488

1.444262611

Patient_273

3

1 (ALIVE)

49

0.895249

1.381196087

Patient_274

1A

1 (ALIVE)

45

0.919811

1.041278582