Summary

This collection contains data from the Children’s Oncology Group (COG) Clinical Trial NCT00274937, “Radiation Therapy, Amifostine, and Chemotherapy in Treating Young Patients With Newly Diagnosed Nasopharyngeal Cancer". Principal Investigator: Carlos Rodriguez-Galindo, MD.  It was sponsored by NCI and performed by the Children's Oncology Group under study number ARAR0331. This phase III trial is studying how well radiation therapy, amifostine, and chemotherapy work in treating young patients with newly diagnosed nasopharyngeal cancer. Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs, such as amifostine, may protect normal cells from the side effects of radiation therapy. Drugs used in chemotherapy, such as cisplatin and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving radiation therapy together with amifostine and chemotherapy may kill more tumor cells. Select patient-level data from this trial is available via the following link: https://nctn-data-archive.nci.nih.gov/node/1302.  

Trial Outcomes

Results of the trial have been reported in the following publications:

  • Jeha S, Pei D, Choi J, Cheng C, Sandlund JT, Coustan-Smith E, Campana D, Inaba H, Rubnitz JE, Ribeiro RC, Gruber TA, Raimondi SC, Khan RB, Yang JJ, Mullighan CG, Downing JR, Evans WE, Relling MV, Pui CH. Improved CNS Control of Childhood Acute Lymphoblastic Leukemia Without Cranial Irradiation: St Jude Total Therapy Study 16. J Clin Oncol. 2019 Dec 10;37(35):3377-3391. doi: 10.1200/JCO.19.01692. Epub 2019 Oct 28.
  • Rodriguez-Galindo C, Krailo MD, Krasin MJ, Huang L, McCarville MB, Hicks J, Pashankar F, Pappo AS. Treatment of Childhood Nasopharyngeal Carcinoma With Induction Chemotherapy and Concurrent Chemoradiotherapy: Results of the Children's Oncology Group ARAR0331 Study. J Clin Oncol. 2019 Dec 10;37(35):3369-3376. doi: 10.1200/JCO.19.01276. Epub 2019 Sep 25. Erratum in: J Clin Oncol. 2021 May 10;39(14):1602.




Data Access

This is a limited access data set. To request access please register an account on the NCTN Data Archive.  After logging in, use the "Request Data" link in the left side menu.  Follow the on screen instructions, and enter  NCT00274937 when asked which trial you want to request.  In step 2 of the Create Request form, be sure to select “Imaging Data Requested”. Please contact NCINCTNDataArchive@mail.nih.gov for any questions about access requests.

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Detailed Description

Image Statistics

Radiology Image Statistics

Modalities

CT, MR ,NM ,PT ,RTIMAGE

Number of Patients

108

Number of Studies

803

Number of Series

7010

Number of Images

330052

Images Size (GB)119



Citations & Data Usage Policy

Rodriguez-Galindo, C., Krailo, M. D., Krasin, M. J., Huang, L., McCarville, M. B., Hicks, J., Pashankar, F., & Pappo, A. S. (2022). Radiation Therapy, Amifostine, and Chemotherapy in Treating Young Patients With Newly Diagnosed Nasopharyngeal Cancer (ARAR0331) (Version 1) [Data set]. The Cancer Imaging Archive. https://doi.org/10.7937/WTEC-MN22


Rodriguez-Galindo, C., Krailo, M. D., Krasin, M. J., Huang, L., McCarville, M. B., Hicks, J., Pashankar, F., & Pappo, A. S. (2019). Treatment of Childhood Nasopharyngeal Carcinoma With Induction Chemotherapy and Concurrent Chemoradiotherapy: Results of the Children’s Oncology Group ARAR0331 Study. In Journal of Clinical Oncology (Vol. 37, Issue 35, pp. 3369–3376). American Society of Clinical Oncology (ASCO). https://doi.org/10.1200/jco.19.01276. PMCID: PMC6920031


Clark, K., Vendt, B., Smith, K., Freymann, J., Kirby, J., Koppel, P., Moore, S., Phillips, S., Maffitt, D., Pringle, M., Tarbox, L., & Prior, F. (2013). The Cancer Imaging Archive (TCIA): Maintaining and Operating a Public Information Repository. In Journal of Digital Imaging (Vol. 26, Issue 6, pp. 1045–1057). Springer Science and Business Media LLC. https://doi.org/10.1007/s10278-013-9622-7

Other Publications Using This Data

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Version 1 (Current): Updated 2022/10/21

Data TypeDownload all or Query/Filter

Images (DICOM, 119 GB)







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