Summary

The TCGA Breast Phenotype Research Group is part of the CIP TCGA Radiology Initiative focused on analyzing images from the TCGA-BRCA collection. These images correlate to the Breast Invasive Carcinoma (BRCA) data in the TCGA Data Portal.

According to The Cancer Genome Atlas page on invasive breast cancers researchers have:

Described new integrated insights into the four standard molecular subtypes of breast cancer: HER2-enriched, Luminal A, Luminal B, and Basal-like
- Also, identified mutated genes that are specific to each subtype
Found that the Basal-like subtype shares many genetic features with high-grade serous ovarian cancer suggesting that the cancers have a common molecular origin and may share therapeutic opportunities
Performed computational analyses that suggest that Basal-like breast cancer and serous ovarian cancer might both be susceptible to two types of cancer treatment
- A drug that inhibits blood vessel growth, cutting off the blood supply to the tumor
- Bioreductive drugs, which are inactive drugs that become toxic to cancer cells under low oxygen conditions

Research and Publications

Data Source	Status
TCGA Data Portal Publication Guidelines	No restrictions; all data available without limitations
TCIA Data Usage Policies and Restrictions	No restrictions; all data available without limitations

Please contact us at cancerimagingarchive@mail.nih.gov if you have any questions about these policies.

TCGA Breast Marker Paper and Image Source Sites (ISS)

Imaging Source Site (ISS) Groups will be populated and governed by participants from institutions that have provided imaging data to the archive for a given cancer type. Modeled after TCGA analysis groups, these groups are given the opportunity to publish a marker paper for a given cancer type per the aforementioned publication policy. It is hoped that this will generate increased participation in the building of these multi-institutional data sets that become an open community resource. Current TCGA-BRCA source sites include:

Mayo Clinic
Roswell Park Cancer Institute
Memorial Sloan-Kettering Cancer Center
University of Pittsburgh / UPMC

Please contact Dr. Elizabeth Morris (morrise@mskcc.org) if you have scientific questions you would like to direct to the TCGA-BRCA ISS or are interested in collaborating with their group.

References

The following links contain publications from the main TCGA project, as well as their posted publication guidelines.