Imaging biomarkers and particularly tumor blood volume estimates have shown to provide additional patient prognostic information (1-6), even independent of the histological grade in gliomas and also specifically within the high-grade glioma group.
Raw and post-processed image subsets of the TCGA-GBM collection can be used to evaluate the role of tumor blood volume estimated using DSC T2* magnetic resonance (MR) perfusion in GBM. This data can be correlated with information in genomic publications or information from the TCGA Data Portal for survival prediction and comparison of other genomic and clinical results.
The post-processed studies were generated with nordicICE software (NordicImagingLab AS) using the FDA approved DSCT2* perfusion module. The module corrects for contrast agent leakage from the intravascular to extracellular space using the method published by Boxerman et al (7). Normalized relative cerebral blood volume (rCBV) maps with leakage correction were produced by the software, which normalizes the CBV relative to a globally determined mean value.
All the regions of interest (ROI) were drawn by Rajan Jain and Jayant Narang (Henry Ford Hospital) in consensus on the rCBV maps fused with post-contrast T1W images and FLAIR images. rCBV mean, rCBV max and rCBVNEL were measured from the rCBV maps and stored in a spreadsheet. For measuring rCBV mean ROI's were drawn on the contrast enhancing portion of the tumor (excluding any areas of necrosis and vessels) on all the slices which contained the tumor and a mean of these was obtained. For measuring rCBVmax an ROI of 10 x 10 voxels was placed on the hottest appearing part of the tumor based on the qualitative perfusion maps. An ROI of 10 x 10 voxels was placed on three spots on non-enhancing FLAIR abnormality within 1 cm of the edge of the enhancing lesion to measure rCBVNEL and obtain a mean.
Note: References listed at the bottom of this page
The following supporting documentation is available for download:
The following 2 Shared Lists provide an easy way to download only the raw and post-processed image subsets of the TCGA-GBM collection described in the project summary.
If you are not familiar with TCIA's Shared List functionality more information can be found in section 3.7 of The Cancer Imaging Archive User's Guide.
TCIA would like to thank Dr. Rajan Jain and Dr. Jayant Narang for processing and uploading the studies generated they generated with nordicICE, as well as providing the associated spreadsheet and text files.