Microscopic images were captured from bone marrow aspirate slides of patients diagnosed with B-lineage Acute Lymphoid Leukemia (B-ALL) and Multiple Myeloma (MM) as per the standard guidelines. Slides were stained using Jenner-Giemsa stain. Images were captured at 1000x magnification using Nikon Eclipse-200 microscope equipped with a digital camera. Images were captured in raw BMP format with a size of 2560x1920 pixels. In all, this dataset consists of 90 images of B-ALL and 100 images of MM. Both MM and B-ALL images have sufficient variability from one image to another image to rigorously test any stain normalization methodology developed. More information about each subset are provided on the Detailed Description tab below.