Pre-clinical animal models of spontaneous metastatic cancer are infrequent; the few that exist are resource intensive because determination of the presence of metastatic disease, metastatic burden, and response to therapy normally require multiple timed cohorts with animal sacrifice and extensive pathological examination. We identified and characterized a patient derived xenograft model with metastatic potential, melanoma xenograft 425362-245-T. In this study we performed a detailed imaging characterization (workflow below) of this model, which develops spontaneous lung metastases, details are provided in the attached standard operating procedures. Tumors in half of the mice were resected in the range 200-300 cm3 size; tumors in the other half were allowed to grow until it was necessary to euthanize them because of tumor size. 

The imaging characteristics of this model, which is available from the National Cancer Institute Patient-Derived Models Repository (, is highly favorable for preclinical research studies of metastatic disease when used in conjunction with non-contrast T2 weighted MRI

Melanoma PDMR-425362-245-T model can be challenging due to the rapid growth of the xenograft and regrowth.  Metastases was well observed on T2 MRI imaging allowing non-invasive evaluation in treatment trials.


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Detailed Description

Image Statistics



Number of Subjects


Number of Studies


Number of Series


Number of Images


Images Size (GB)2.3 GB

# animals in group

# animals that displayed metastasis in MRI and confirmed by Pathology

Pathology confirmation of MRI (primary imaging site)

Other confirmed Location (s)

10 (non-resected)


(4 mice were EU due to xenograft size prior to observation of metastasis)


Lymph node

10 (resected)



Lymph node

Percent penetrance with respect to the average time-to-metastasis for non-resected (plot A: time from implant) and resected (plot B: time from tumor resection) cohorts.


   Plot A                                                                                          Plot B

PET/CT Characterization of the primary tumor:  Baseline PET (SOP attached) were performed when tumor reached an approximate 200 mm3.   Average SUVmax values (n=5) were calculated; [18F]FDG: 2.7 ± 0.5 and [18F]FLT: 2.0 ± 0.3.


Melanoma PDMR-425362-245-T model can be challenging due to the rapid growth of the xenograft and regrowth.  Metastases was well observed on T2 MRI imaging allowing non-invasive evaluation in treatment trials.


Citations & Data Usage Policy

These collections are freely available to browse, download, and use for commercial, scientific and educational purposes as outlined in the Creative Commons Attribution 3.0 Unported License. Questions may be directed to Please be sure to acknowledge both this data set and TCIA in publications by including the following citations in your work:

Tatum, J. L., ( Kalen, J. D., ( Jacobs, P. M., ( Ileva, L. V., ( Riffle, L. A., ( Keita, S., Patel, N., ( Sanders, C., ( James, A., Difilippantonio, S., ( Thang, L. Hollingshead, M. G., ( Phillips, J., Edmondson, E Evrard, Y., Clunie, D. A, ( Liu, Y., Smith, K. E, ( Wagner, U., ( Freymann, J. B. Kirby, J., Doroshow, J. H, (

This project has been funded in whole or in part with Federal funds from the National Cancer Institute, National Institutes of Health, under Contract No. HHSN261201500003I. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government.

Clark K, Vendt B, Smith K, Freymann J, Kirby J, Koppel P, Moore S, Phillips S, Maffitt D, Pringle M, Tarbox L, Prior F. The Cancer Imaging Archive (TCIA): Maintaining and Operating a Public Information Repository, Journal of Digital Imaging, Volume 26, Number 6, December, 2013, pp 1045-1057. DOI:

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