Summary

This project set out to present the first comprehensive radiogenomic analysis using quantitative MRI volumetrics and large-scale gene- and microRNA expression profiling in GBM. This project was led by Pascal Zinn and Rivka Colen of MDACC and BWH respectively. The following publication was written on the subject and published in PLoS ONE: Radiogenomic Mapping of Edema/Cellular Invasion MRI-Phenotypes in Glioblastoma Multiforme.

Supporting Documentation and Metadata

Shared Lists

The following Shared Lists have been created to easily obtain the subset of TCGA-GBM relevant to this study.

• Radiogenomic Mapping of Edema/Cellular Invasion MRI-Phenotypes: Consists of only the 78 subjects which were reviewed for their publication. From these cases the PLoS ONE article indicates two sequences from each case were used for the study: 1) Fluid-Attenuated Inversion Recovery (FLAIR) for segmentation of the edema and 2) post-contrast T1 weighted imaging (T1WI) for segmentation of enhancement (defined as tumor) and necrosis.

Note: See Section 3.7 of TCIA User Guide for help with Shared Lists.

3D Segmentations, Clinical and Genetic data

The corresponding clinical and genetic data for the patients in this study can be obtained from the TCGA Data Portal.  The 3D segmentations were created in Slicer and may be made available upon request.  Please contact us for more information: cancerimagingarchive@mail.nih.gov.