Imaging data from clinical trials provides the opportunity to link imaging characteristics to clinical trial analyses, associated clinical data and patient outcomes. Beginning in 2019, the NCI Cancer Imaging Program Informatics Lab is supporting an additional TCIA image data collection center focused specifically on clinical trial data. Many TCIA clinical trial data sets will originate from the NCI National Clinical Trials Network (NCTN), which is a collection of organizations and clinicians that coordinates and supports cancer clinical trials at more than 3,000 sites across the United States and Canada. The NCTN provides the infrastructure for NCI-funded treatment, screening, and diagnosis trials to improve the lives of patients with cancer. The NCTN explicitly requires data sharing of the patient-level clinical data in https://nctn-data-archive.nci.nih.gov/view-trials, and TCIA serves as the imaging repository for that archive.