Driven by input from its scientific community, the Cancer Imaging Program (CIP) finds itself at the junction of two powerful scientific requisites; the need for cross-disciplinary research and inter-institutional data-sharing to speed scientific discovery and reduce redundancy, and the need to provide imaging phenotype data to augment large scale genomic analysis. |
As an opportunity to leverage that wealth of new biomedical knowledge, CIP committed substantial effort to gather and place the clinical diagnostic images that match the genomically analyzed TCGA tissue cases in The Cancer Imaging Archive. CIP encouraged an ad hoc image research team to study glioblastoma. The Cancer Imaging Archive now contains a TCGA GBM collection with images from more than 200 subjects whose molecular and clinical patient data can be accessed in the TCGA Data Portal. A multi-institutional team coordinated by Dr Adam Flanders of Thomas Jefferson University assembled researchers from across the country to create the TCGA Glioma Phenotype Research Group. In less than a year's time they have quickly demonstrated the advantages of such scientific collaboration by their rapid scientific progress with a number of publications and abstracts presented and in the pipeline for future venues.
Presently, CIP is developing agreements with many of the TCGA Tissue Site Source institutions to recover and place in the Image Archive collections of diagnostic images that match the genomic data now being deposited in the publically accessible TCGA Data Portal on cancers of the brain (GBM/LGG), breast (BRCA), renal (KIRC), lung (LUAD), and in due time, many of the future 20-plus tumors that TCGA will characterize as the program moves forward. Imaging Source Site (ISS) Groups are being created and governed by participants from institutions that have provided imaging data to the archive for a given cancer type. Modeled after TCGA analysis groups, these groups are given the opportunity to publish a marker paper for a given cancer type per the aforementioned publication policy. It is hoped that this will generate increased participation in the building of these multi-institutional data sets that become an open community resource.
TCIA publication guidelines are derived from the policy outlined by the The Cancer Genome Atlas. These must be followed in addition to the publication policy of the TCGA Data Portal: http://cancergenome.nih.gov/abouttcga/policies/publicationguidelines.
There are no limitations on publications containing analyses using any TCGA-linked imaging data set if the data set meets one of the following three freedom-to-publish criteria:
Imaging Source Site (ISS) Groups will be populated and governed by participants from institutions that have provided imaging data to the archive for a given cancer type. Modeled after TCGA analysis groups, these groups are given the opportunity to publish a marker paper for a given cancer type per the aforementioned publication policy. It is hoped that this will generate increased participation in the building of these multi-institutional data sets that become an open community resource.
Specifically, the status of each tumor data set is available below. If you have questions, do not hesitate to contact cancerimagingarchive@mail.nih.gov.
Tumor Type |
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No restrictions; all data available without limitations |
No restrictions; image data available without limitations |
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No restrictions; all data available without limitations |
Publication limitations in place until 08/22/2013 |
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No restrictions; all data available without limitations |
Publication limitations in place until 10/16/2013 |
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Publication limitations in place until 5/30/2013 |
Projects have not reached 100 imaging cases; Please check with cancerimagingarchive@mail.nih.gov prior to any publication |
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Publication limitations in place until 3/11/2014 |
Projects have not reached 100 imaging cases; Please check with cancerimagingarchive@mail.nih.gov prior to any publication |
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Projects have not reached 100 cases; Please check with tcga@mail.nih.gov prior to any publication |
Projects have not reached 100 imaging cases; Please check with cancerimagingarchive@mail.nih.gov prior to any publication |
Continuing these efforts CIP is working to encourage ad hoc multi-institutional research teams for analysis of these data sets as they are collected. Efforts have already begun or are being initiated for the following TCGA tissue types:
Group Name |
Tumor Type |
Status |
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Open |
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ISS only |
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ISS only |
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ISS only |
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ISS only |
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ISS only |
Please contact us at cancerimagingarchive@mail.nih.gov if you would like to discuss how we might help with your research, or if you'd like to join our public mailing lists to receive notifications of newly available data and other news items related to these data sets. Points of contact for collaborating with the existing research groups can be found on their respective pages.
Included below are some posters and presentations which help summarize the CIP TCGA Radiology Initiative and its supporting components such as TCIA.
The following links contain publications from the main TCGA project, as well as their posted publication guidelines.