from proposal form (needs revision):

The annotation protocol consists of longitudinal volumetric segmentations and seed points of neoplastic lymph nodes and tumor. The annotation protocol closely aligns with the baseline and followup imaging design of the AHOD0831 clinical trial. The goal of the annotation protocol is to provide consistent and detailed therapy response assessment. The volumetric segmentations are provided in DICOM Segmentation format and seed points (kernels) are provided as POINT structures in DICOM RTSS format.

Annotation of imaging sequences was chosen with maximum clinical utility in mind. The neoplastic lymph nodes and areas of tumor were annotated on the attenuation correct PET as well as the post contrast axial series. If post contrast imaging was not avialble, the axial non contrast CT series was used. A maximum of 5 lesions were annotated per patient scan (timepoint); no more than 2 per organ. The same 5 lesions were annotated at each time point, unless a previously annotated lesion resolved. RECIST 1.1 and PERCIST principles were generally followed for lesion annotation. Bone lesions were included if other lesions were not present. Lesions were labeled separately. Seed points were automatically generated but were reviewed by a radiologist. SNOMED codes were attached to the annotations documents all locations involved.