Page History

Data Access

Click the Versions tab for more info about data releases.

Please contact help@cancerimagingarchive.net  with any questions regarding usage.

• Imaging Data Commons (IDC) (Imaging Data)

The following external resources have been made available by the data submitters.  These are not hosted or supported by TCIA, but may be useful to the researchers utilizing this collection

• Clinical data

This is a subset of the full clinical data.  If you need the full clinical data, please visit the Cancer Data Access System (CDAS) system.

Detailed Description

The full CT data (manifest-NLST_allCT.tcia) occupy 11.3 terabytes when downloaded. For convenience, you can "Search" to access all the files, or you can download in chunks

. 

The pathology slide data: 

1. Primary Tumor slides (faspex) Primary Tumor slides (the standard package), 1225 files.

2. Additional slides (faspex) Additional histopathology slide images for which the participants have no Baseline Questionnaire data (4 slides) Detail in Table 1.

3. Second Primary-Tumor slides (faspex) Additional histopathology slide images for participants with Second Primary Tumors as well as those included in the "standard" package (23 slides) Detail in Table 2. 

NLST Design & Process, Protocol Documents, and Results: https://cdas.cancer.gov/learn/nlst/main-findings/

• Overview, study design, recruitment methods, endpoint verification process (determining cause of death), quality control (LSS and ACRIN).
• LSS Manual of Operations (MOOP) and ACRIN Protocol.
• DSMB announcement of results (10/28/2010).
• Feasibility Study for the NLST, Psychosocial and Behavioral Issues, Technical Publications. https://cdas.cancer.gov/learn/nlst/main-findings/
• Browse Publications : https://cdas.cancer.gov/publications/?study=nlst
• Browse projects : https://cdas.cancer.gov/approved-projects/?data_types=nlst_data

NLST Data Collected: https://biometry.nci.nih.gov/cdas/learn/nlst/data-collected/

• Questionnaires, screening, diagnostic procedures, cancer diagnosis, treatment, progression, mortality, contamination.

Biospecimens Collected

Formalin-fixed paraffin embedded (FFPE) tissue specimens are available for a subset of the NLST participants who developed lung cancer during the trial. Donor blocks were obtained from local pathology laboratories and tissue cores (0.6mm) were extracted from them to construct tissue microarrays (TMA). Tissue cores were sampled from primary main invasive tumor histology, secondary tumor histology, carcinoma in situ, adjacent normal lung tissue, metastatic lesion from lymph node(s) and/or distant sites, benign (un-involved) lymph node, proximal and/or distal bronchi.

In total, tissue materials were collected from 438 lung cancer cases. All have cores arrayed across nine TMAs, one of which only contains tissue collected after neoadjuvant treatment. 434 of these also have loose cores available for nucleic acid extraction. On average, each TMA contains 504 cores from 48 subjects.

Applications for access to these specimens can be submitted under the PLCO Etiologic and Early Marker Studies Program (EEMS). The application review process opens twice a year, once in the winter and once in the summer. For more information about EEMS and to initiate an application visit the PLCO EEMS Application page. When filling out the application, specify “NLST Tissue” under the case definition.

Citations & Data Usage Policy 

Other Publications Using This Data

TCIA maintains a list of publications which leverage TCIA data. If you have a manuscript you'd like to add please contact the TCIA Helpdesk.

IMS/CDAS maintains a separate list of publications related to NLST data: https://cdas.cancer.gov/publications/?study=nlst 

Version 3 (Current) : Updated 2021/09/24

Data embargo of limited access is lifted September 2021, with the addition of downloadable pathology slide data and clinical data spreadsheet & dictionaries.

Version 2: Updated 2015/12/14

Change: restoration of images that had become corrupted/missing during a storage transfer.

Version 1 (Current): Updated 2013/03/01