The National Lung Screening Trial (NLST)
An NLST summary, found at the link below, is offered through the Cancer Data Access System (CDAS) maintained by Information Management System (IMS), contracted by the National Cancer Institute (NCI) as keepers and statistical analyzers of the NLST trial data. The summary includes:
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https://biometry.nci.nih.gov/cdas/nlst/learn/trial_sum
NLST Design & Process, Protocol Documents, and Results
- Overview, study design, recruitment methods, endpoint verification process (determining cause of death), quality control (LSS and ACRIN).
- LSS Manual of Operations (MOOP) and ACRIN Protocol.
- DSMB announcement of results (10/28/2010).
https://biometry.nci.nih.gov/cdas/nlst/learn/main_findings
NLST Publications and Projects
- Primary Results, Study Design, Feasibility Study for the NLST, Psychosocial and Behavioral Issues, Technical Publications.
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https://biometry.nci.nih.gov/cdas/nlst/pubs_projects
NLST Data Collected
- Questionnaires, screening, diagnostic procedures, cancer diagnosis, treatment, progression, mortality, contamination.
https://biometry.nci.nih.gov/cdas/nlst/learn/data_collected
Accessing NLST Trial Data and Images
Data and images are owned by the National Cancer Institute (NCI) and subject to IRBs at NCI and at the institutions through which participants were recruited. NLST summary, design, protocols, and results are well-described and publicly available; see:
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https://biometry.nci.nih.gov/cdas/studies/nlst
> Non-image Data
Investigators with approved access to NLST data may acquire copies of data in two different ways:
- Directly from IMS
Investigators with an approved request may download comprehensive NLST datasets directly from the CDAS website. Datasets are provided in SAS format in one compressed file (.zip); other formats are available upon request. - Indirectly, through the Query Tool (QT): NLST Database Query Tool
Investigators launch the web-based QT, make menu-driven queries against the QT database (a significant subset of all trial data), and save query results to an Excel spreadsheet. The chief advantage to the QT is the ability to rapidly adjust queries and build a final spreadsheet for analysis. In addition, the QT offers the ability to download associated CT image
> Images
CT images: All CT images are available to investigators with approved access to NLST data and images. The chest X-rays are not available. Subsets of the CT images may be obtained in two ways:
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- For more details about how to use caMicroscope and annotate the images, see the the caMicroscope User's Guide
NLST Image-related Queries and Image Download Metrics
- Measures of image and data consumption are described here.
Contact Information
For anything regarding the NLST protocols, data, findings, projects, and publications:
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Please contact The Cancer Imaging Archive Support group at help@cancerimagingarchive.net or call +1.314.747-4254