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Mappings of tumor-infiltrating lymphocytes (TILs), based on H&E images from 13 of The Cancer Genome Atlas (TCGA) tumor types are available here. These TIL maps are derived through computational staining, using a convolutional neural network trained to classify patches of images. In addition to the TIL Maps, the analysis codes and the software used to extract TILs are also available. The accompanying paper contains detailed information about our methods and our findings. The source histopathology, molecular correlates and clinical data used in this study can be found on the Genomic Data Commons.
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Additional information about common questions investigators have while using this dataset are addressed in the FAQs document.
More information about the tools used to generate these results can be found at:
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| title | Data Access |
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| Data Access| Data Type | Download all or Query/Filter |
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| TIL Maps | | | H&E Images and Clinical Data (external) | | | Clinical and Molecular Correlates (external) | |
Note: Please contact help@cancerimagingarchive.net with any questions regarding usage. |
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| title | Detailed Description |
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| Detailed Description
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| title | Citations & Data Usage Policy |
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| Citations & Data Usage Policy These collections are freely available to browse, download, and use for commercial, scientific and educational purposes as outlined in the Creative Commons Attribution 3.0 Unported License. Questions may be directed to help@cancerimagingarchive.net. Please be sure to acknowledge both this data set and TCIA in publications by including the following citations in your work: | Info |
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| Saltz, J., Gupta, R., Hou, L., Kurc, T., Singh, P., Nguyen, V., … Thorsson, V. (2018). Tumor-Infiltrating Lymphocytes Maps from TCGA H&E Whole Slide Pathology Images [Data set]. The Cancer Imaging Archive. https://doi.org/10.7937/k9/tcia.2018.y75f9w1 |
| Info |
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| Clark K, Vendt B, Smith K, Freymann J, Kirby J, Koppel P, Moore S, Phillips S, Maffitt D, Pringle M, Tarbox L, Prior F. The Cancer Imaging Archive (TCIA): Maintaining and Operating a Public Information Repository, Journal of Digital Imaging, Volume 26, Number 6, December, 2013, pp 1045-1057. (paper) |
In addition to the dataset citation above, please be sure to cite the following if you utilize these data in your research: | Info |
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| title | Publication Citation |
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| Saltz, J., Gupta, R., Hou, L., Kurc, T., Singh, P., Nguyen, V., . . . Thorsson, V. Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images. Cell Reports, 23(1), 181-193.e187. https://doi.org/10.1016/j.celrep.2018.03.086 |
Other Publications Using This DataTCIA maintains a list of publications that leverage TCIA data. If you have a manuscript you'd like to add please contact the TCIA Helpdesk. |
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| Version 1 (Current): 2018/12/17| Data Type | Download all or Query/Filter |
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| TIL Maps | | | H&E Images and Clinical Data (external) | | | Clinical and Molecular Correlates (external) | |
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