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Four proteins were associated with CT-based imaging traits, with the strongest correlation observed between the CRIP2 protein and disease in the mesentery (p<0.001, AUC=0.05). The abundance of three proteins was associated with texture features that represented intra-and inter-site tumour heterogeneity, with the strongest negative correlation between the CKB protein and cluster dissimilarity (p=0.047, 𝜏 t =0.326).
Conclusion
This study provides the first insights into the potential associations between standard-of-care CT imaging traits and texture measures of intra-and inter-site heterogeneity, and the abundance of several proteins.
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