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This dataset contains image annotations derived from "The Clinical Proteomic Tumor Analysis Consortium Clear Cell Renal Cell Carcinoma Collection (CPTAC-CCRCC)”.  This dataset was generated as part of a National Cancer Institute project to augment images from The Cancer Imaging Archive with annotations that will improve their value for cancer researchers and artificial intelligence experts.

Annotation Protocol

For each patient, all scans were reviewed to identify and annotate the clinically relevant time points and sequences/series. In a typical patient all available time points were annotated. The following annotation rules were followed:

1. RECIST 1.1 was generally followed for MR and CT imaging. A maximum of 5 lesions were annotated per patient scan (timepoint); no more than 2 per organ. The same 5 lesions were annotated at each time point. Lymph nodes were annotated if > 1 cm in short axis. Other lesions were annotated if > 1 cm. If the primary lesion measures < 1 cm, it was still annotated.
2. Three-dimensional segmentations of lesions were created in the axial plane. If no axial plane was available, lesions were annotated in the available plane.
3. MRIs were annotated using all axial T1-weighted post contrast sequences.
4. CTs were annotated using all axial post contrast series.
5. Lesions were labeled separately.
6. Seed points were automatically generated, but reviewed by a radiologist.
7. A “negative” annotation was created for any exam without findings.

At each time point:

1. Volume calculations were performed for each segmented structure.  These calculations are provided in the Annotation Metadata CSV.
2. A seed point (kernel) was created for each segmented structure. The seed points for each segmentation are provided in a separate DICOM RTSTRUCT file. 
3. SNOMED-CT “Anatomic Region Sequence” and “Segmented Property Category Code Sequence” and codes were inserted for all segmented structures.
4. “Tracking ID” and “Tracking UID” tags were inserted for each segmented structure to enable longitudinal lesion tracking.
5. Imaging time point codes were inserted to help identify each annotation in the context of the clinical trial assessment protocol. 
   1. “Clinical Trial Time Point ID” was used to encode time point type using one of the following strings as applicable: “pre-dose” or “post-chemotherapy”.
   2. Content Item in “Acquisition Context Sequence” was added containing "Time Point Type" using Concept Code Sequence (0040,A168) selected from:
      1. (255235001, SCT, “Pre-dose”)
      2. (719864002, SCT, "Post-cancer treatment monitoring")

Important supplementary information and sample code

1. A spreadsheet containing key details about the annotations is available in the Data Access section below.
2. A Jupyter notebook demonstrating how to use the NBIA Data Retriever Command-Line Interface application and the REST API to access these data can be found in the Additional Resources section below.