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This dataset contains image annotations derived from the NCI Clinical Trial "Vincristine, Dactinomycin, and Doxorubicin With or Without Radiation Therapy or Observation Only in Treating Younger Patients Who Are Undergoing Surgery for Newly Diagnosed Stage I, Stage II, or Stage III Wilms' Tumor (AREN0532)”.  The key objective of this project is to generate a large and highly curated imaging dataset of pediatric Wilms tumor patients with annotations suitable for cancer researchers and AI developers.

Annotation Protocol

For each patient, every DICOM Study and DICOM Series was reviewed to identify and annotate the clinically relevant time points and sequences. In a typical patient the following annotation rules were followed:

1. The primary renal tumor(s) were annotated on post-contrast axial series. Normal renal parenchyma were excluded. 
2. A maximum of 5 lesions were annotated per patient scan (timepoint); no more than 2 per organ. The same 5 lesions were annotated at each time point.  RECIST 1.1 principles were generally be followed for lesion annotation, however, if <5 lesions measuring >1 cm were present, then smaller lesions were annotated, again up to 2 lesions per organ or 5 lesions per patient scan. Bone lesions were included if other lesions were not present. 
3. Lesions were labeled separately.
4. Seed points were automatically generated but were reviewed by a radiologist.

At each time point:

1. A seed point (kernel) was created for each segmented structure. The seed points for each segmentation are provided in a separate DICOM RTSS file. 
2. SNOMED-CT “Anatomic Region Sequence” and “Segmented Property Category Code Sequence” and codes were inserted for all segmented structures.
3. Imaging time point codes were inserted to help identify each annotation in the context of the clinical trial assessment protocol. 
   1. “Clinical Trial Time Point ID” was used to encode time point type using one of the following strings as applicable: “pre-dose” or “post-chemotherapy”
   2. Content Item in “Acquisition Context Sequence” was added containing "Time Point Type" using Concept Code Sequence (0040,A168) selected from:
      1. (255235001, SCT, “Pre-dose”)
      2. (262502001, SCT, "Post-chemotherapy")
      3. (262502001, SCT, "Post-chemotherapy")
      4. (262502001, SCT, "Post-chemotherapy")
      5. etc. 

Important supplementary information and sample code

1. A spreadsheet containing key details about the annotations is available in the Data Access section below.
2. A Jupyter notebook demonstrating how to use the NBIA Data Retriever Command-Line Interface application and the REST API (with authentication) to access these data can be found in the Additional Resources section below.

Click the Versions tab for more info about data releases.

Additional Resources for this Dataset

Note to curators! Use this any time you are linking to NCI's IDC/GDC/PDC resources.  The links below are examples and will need to be tailored to point to the specific dataset (see parameters in URLS).

Proteomic Data Commons (PDC) (Proteomic & Clinical Data)

Genomic Data Commons (GDC) (Genomic & Clinical Data)

Note to curators! The link below is an example for NCTN trials and will need to be tailored to the proper URL for the corresponding data on the NCTN Data Archive.

Nctn additional resources

• NCTN/NCORP Data Archive (Clinical Data)

Note to curators! Below are examples for what to do with other external resources/links that don't fit into the above categories.

The following external resources have been made available by the data submitters.  These are not hosted or supported by TCIA, but may be useful to researchers utilizing this collection.

• Software / Code on Github
• Genomics data in DbGAP
• Genomics data in Gene Expression Omnibus

Third Party Analyses of this Dataset

Collections Used in this Third Party Analyses

TCIA encourages the community to publish your analyses of our datasets. Below is a list of such third party analyses published using this Collection:

• <add links to TCIA Analysis Result DOIs here>Vincristine, Dactinomycin, and Doxorubicin With or Without Radiation Therapy or Observation Only in Treating Younger Patients Who Are Undergoing Surgery for Newly Diagnosed Stage I, Stage II, or Stage III Wilms' Tumor (AREN0532)