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Description
This study describes a subset of the HNSCC collection on TCIA.
PURPOSE:
Cross sectional imaging is essential for the patient-specific planning and delivery of radiotherapy, a primary determinant of head and neck cancer outcomes. Publicly shared RT data is scarce due to high complexity of RT structure data and the need for registration in time, space, and across planning sets. We here introduce an open access imaging database for patients treated with radiotherapy for
Summary
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head and neck squamous cell carcinoma (HNSCC).
MATERIALS AND METHODS:
2840 consecutive patients with HNSCC treated with
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curative-intent RT at MD Anderson
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Cancer Center from 2003 to 2013 were screened. Patients with whole-body PET-CT or abdominal CT scans both before and after RT were included (n=215). Clinical data were retrieved from the MD Anderson Cancer Center custom electronic medical record system, ClinicStation. Using cross sectional imaging, we calculated total body skeletal muscle and adipose content before and after treatment. All files were de-identified and transferred to The Cancer Imaging Archive servers using the RSNA Clinical Trial Processor program. Files were screened for errors or residual PHI using TagSniffer and Posda Tools software, reviewed by TCIA curators, then confirmed at the parent institution.
RESULTS:
The HNSCC collection is a dataset consisting of 433,384 DICOM files from 3,225 series and 765 studies collected from 215 patients, which includes de-identified diagnostic imaging, radiation treatment planning, and follow up imaging. All imaging data are subject- and date-matched to clinical data from each patient, including demographics, risk factors, grade, stage, recurrence, and survival.
CONCLUSION:
Recent advances in data archiving, patient de-identification, and image registration have allowed for the creation of a high quality RT-enriched imaging database within TCIA. Open access to these data allows for interinstitutional comparisons of complete RT details in non-randomized patient populations, allowing for a more granular understanding of three dimensional factors that influence treatment effectiveness and toxicity sparing.
A related dataset describing the other component of the the HNSCC collection is here: Radiomics outcome prediction in Oropharyngeal cancer DOI: 10.7937/TCIA.2020.2vx6-fy46
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Acknowledgements:
This research was supported by the Andrew Sabin Family Foundation; Dr. Fuller is a Sabin Family Foundation Fellow. Drs. Mohamed and Fuller receive funding support from the National Institutes of Health (NIH)/National Institute for Dental and Craniofacial Research (NIDCR) (R01DE025248) and the National Institutes of Health (NIH)/National Cancer Institute (NCI) (1R01CA214825-01). Dr. Fuller received/(s) grant and/or salary support from the NIH/NCI Head and Neck Specialized Programs of Research Excellence (SPORE) Developmental Research Program Career Development Award (P50CA097007-10); the NCI Paul Calabresi Clinical Oncology Program Award (K12 CA088084-06); a General Electric Healthcare/MD Anderson Center for Advanced Biomedical Imaging In-Kind Award; an Elekta AB/MD Anderson Department of Radiation Oncology Seed Grant; the Center for Radiation Oncology Research (CROR) at MD Anderson Cancer Center Seed Grant; the MD Anderson Institutional Research Grant (IRG) Program; and the NIH/NCI Cancer Center Support (Core) Grant CA016672 to The University of Texas MD Anderson Cancer Center (P30 CA016672). Dr. Elhalawani was directly funded in part by a philanthropic gift from the Family of Paul W. Beach given to Dr. Gunn for patient-outcome database construction.
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Note
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This collection is freely available to browse, download, and use for commercial, scientific and educational purposes as outlined in the Creative Commons Attribution 3.0 Unported License. See TCIA's Data Usage Policies and Restrictions for additional details. Questions may be directed to help@cancerimagingarchive.net.
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Affiliations
1. Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX
2. Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, University of
Alexandria, Alexandria, Egypt
3. Department of Biomedical Informatics, University of Arkansas for Medical Sciences, Little Rock, AR
4. Radiation Oncology Unit, Chulabhorn Hospital, Bangkok, Thailand
5. Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX
6. Leidos Biomedical Research, Inc., Bethesda, MD
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