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Summary

This dataset was used by the NCI's Quantitative Imaging Network (QIN) PET-CT Subgroup for their project titled: Multi-center Comparison of Radiomic Features from Different Software Packages on Digital Reference Objects and Patient Datasets.  The purpose of this project was to assess the agreement among radiomic features when computed by several groups by using different software packages under very tightly controlled conditions, which included common image data sets and standardized feature definitions. 

Image AddedImage AddedImage Added

The image datasets (and Volumes of Interest – VOIs) provided here are the same ones used in that project and reported in the publication listed below (ISSN 2379-1381 https://doi.org/10.18383/j.tom.2019.00031).  In addition, we have provided detailed information about the software packages used (Table 1 in that publication) as well as the individual feature value results for each image dataset and each software package that was used to create the summary tables (Tables 2, 3 and 4) in that publication. 

For that project, nine common quantitative imaging features were selected for comparison including features that describe morphology, intensity, shape, and texture and that are described in detail in the International Biomarker

...

Standardisation Initiative (IBSI, https://arxiv.org/abs/1612.07003  and  publication (Zwanenburg A. Vallières M, et al, The Image Biomarker Standardization Initiative: Standardized Quantitative Radiomics for High-Throughput Image-based Phenotyping. Radiology. 2020 May;295(2):328-338. doi: https://doi.org/10.1148/radiol.2020191145).


Acknowledgements 

The authors gratefully acknowledge the following sources of support:  David Geffen School of Medicine at UCLA, Los Angeles, California, USA  and Stanford University School of Medicine, Stanford, CA, USA.  Special thanks to Michael McNitt-Gray, PhD from UCLA Department of Radiological Sciences and Sandy Napel, PhD from the Stanford Department of Radiology.

  • The National Cancer Institute Quantitative Network (QIN)


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Patient IDs for the 3 DROs from (insert DOI)
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activetrue
titleData Access

Data Access

Click the Download button to save a ".tcia" manifest file to your computer, which you must open with the NBIA Data Retriever. Click the Search button to open our Data Portal, where you can browse the data collection and/or download a subset of its contents.


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Localtab
titleDetailed Description
License
Segmentation (NIfTI, zip, 4 MB)
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urlhttps://wiki.cancerimagingarchive.net/download/attachments/70222123/DRO%20Toolkit-3%20Subjects%20SEG%20and%20QIN%20multi-site%2010%20Subjects%20SEG%20NIfTI.zip?api=v2


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Feature Variability Software Package details (xlsx, 13 kb)
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urlhttps://wiki.cancerimagingarchive.net/download/attachments/70222123/Table%201%20-%20Feature%20Variability%20Software%20Details_v2.xlsx?api=v2


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DRO Results (xlsx, 31 kb)
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Patient Dataset Results (xlsx, 400 kb)
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Harmonized GLCM Entropy Results (xlsx, 17 kb)
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Collections Used in this Third Party Analysis 

Below is a list of the Collections used in these analyses:

Source Data TypeDownloadLicense

Corresponding Original CT images from LIDC-IDRI and DRO-Toolkit (DICOM, 2.0 GB)

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urlhttps://wiki.cancerimagingarchive.net/download/attachments/70222123/Radiomic-Feature-Standards-DICOM%20CTs%203%20Subjects%20DRO%20Toolkit%2010%20Subjects%20QIN.tcia?api=v2

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urlhttps://nbia.cancerimagingarchive.net/nbia-search/?ImageModalityCriteria=CT&MinNumberOfStudiesCriteria=1&PatientCriteria=

Detailed Description

Image Statistics

Modalities

Number of Patients

Number of Studies

Number of Series

Number of Images

Images Size (GB)
Phantom-100.0-1.0-1.0-1.0-9.0-0.0-100.0-10.0-0.0-0.0

,Phantom-100.0-1.0-1.0-1.0-9.0-0.0-100.0-10.0-50.0-0.0

,Phantom-100.0-1.0-1.0-1.0-9.0-0.2-100.0-10.0-0.0-0.0

 
Patient IDs for the 10 LIDC-IDRI subjects (http://doi.org/10.7937/K9/TCIA.2015.LO9QL9SX)
LIDC-IDRI             LIDC-IDRI-0314
LIDC-IDRI             LIDC-IDRI-0325
LIDC-IDRI             LIDC-IDRI-0580
LIDC-IDRI             LIDC-IDRI-0766
LIDC-IDRI             LIDC-IDRI-0771
LIDC-IDRI             LIDC-IDRI-0811
LIDC-IDRI             LIDC-IDRI-0905
LIDC-IDRI             LIDC-IDRI-0963
LIDC-IDRI             LIDC-IDRI-0965
LIDC-IDRI             LIDC-IDRI-1012
,LIDC-IDRI-0314,LIDC-IDRI-0325,LIDC-IDRI-0580,LIDC-IDRI-0766,LIDC-IDRI-0771,LIDC-IDRI-0811,LIDC-IDRI-0905,LIDC-IDRI-0963,LIDC-IDRI-0965,LIDC-IDRI-1012

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Corresponding second-generation SEG images from QIN-LungCT-Seg (DICOM, 123 MB)
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urlhttps://wiki.cancerimagingarchive.net/download/attachments/70222123/Radiomic-Feature-Standards-DICOM%20Segs%203%20Subjects%20DRO%20Toolkit%2010%20Subjects%20QIN.tcia?api=v2

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labelSearch
urlhttps://nbia.cancerimagingarchive.net/nbia-search/?ImageModalityCriteria=SEG&MinNumberOfStudiesCriteria=1&PatientCriteria=Phantom-100.0-1.0-1.0-1.0-9.0-0.0-100.0-10.0-0.0-0.0,Phantom-100.0-1.0-1.0-1.0-9.0-0.0-100.0-10.0-50.0-0.0,Phantom-100.0-1.0-1.0-1.0-9.0-0.2-100.0-10.0-0.0-0.0,LIDC-IDRI-0314,LIDC-IDRI-0325,LIDC-IDRI-0580,LIDC-IDRI-0766,LIDC-IDRI-0771,LIDC-IDRI-0811,LIDC-IDRI-0905,LIDC-IDRI-0963,LIDC-IDRI-0965,LIDC-IDRI-1012

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Localtab
titleDetailed Description

Detailed Description


DICOM Image Statistics


Modalities

CT, SEG

Number of Patients

13

Number of Studies

13

Number of Series

26

Number of Images

3,867

Images Size (GB)2 GB



There are three datasets provided – two image datasets and one dataset consisting of three four excel spreadsheets containing feature values.

  1. The first image dataset is a set of three Digital Reference Objects (DROs) used in the project, which are: (a) a sphere with uniform intensity, (b) a sphere with intensity variation (c) a nonspherical (but mathematically defined) object with uniform intensity. These DROs were created by the team at Stanford University and are described in (Jaggi A, Mattonen SA, McNitt-Gray M, Napel S. Stanford DRO Toolkit: digital reference objects for standardization of radiomic
AQ: F
  1. features. Tomography. 2019;6:–.) and are a subset of the DROs described in
(link to DRO wiki page)
  1. Stanford DRO Toolkit: Digital Reference Objects for Standardization of Radiomic Features. Each DRO is represented in both DICOM and NIfTI format and the VOI was provided in each format as well (DICOM Segmentation Object (DSO) as well as NIfTI segmentation boundary).
  2. The second image dataset is
a
  1. the set of 10 patient CT scans
which is a subset of
  1. , originating from the LIDC-IDRI dataset, that were used in the QIN multi-site collection of Lung CT data with Nodule Segmentations project (
http
  1. https://doi.org/10.7937/K9/TCIA.2015.1BUVFJR7 )
created previously. Specifically, the same 10 cases selected from the LIDC-IDRI dataset that were used in that previous study were used in this study. As in that previous
  1. . In that QIN study, a single lesion from each case was identified for analysis
. That previous study generated VOIs using algorithms from three academic institutions and each method performed three repeat runs on each nodule. For this study, and to
  1. and then nine VOIs were generated using three repeat runs of three segmentation algorithms (one from each of three academic institutions) on each lesion. To eliminate one source of variability in our project, only one of the VOIs previously created for each lesion was identified and all sites used that same VOI definition. The specific VOI chosen for each lesion was the first run of the first algorithm (algorithm 1, run 1).
As in that prior project, both DICOM and NIfTI formats were created
  1. DICOM images were provided for each
image
  1. dataset and the VOI was provided in
each format as well (
  1. both DICOM Segmentation Object (DSO)
as well as
  1. and NIfTI segmentation
boundary)
  1. formats.
  2. The third dataset is a collection of
three
  1. four excel spreadsheets, each of which contains detailed information corresponding to each of the four tables in the publication. For example, the raw feature values and the summary tables for Tables 2,3 and 4 reported in the publication
below. 
  1. cited (https://doi.org/10.18383/j.tom.2019.00031). These tables are:

Software Package details : This table contains detailed information about the software packages used in the study (and listed in Table 1 in the publication) including version number and any parameters specified in the calculation of the features reported.

DRO results : This contains the original feature values obtained for each software package for each DRO as well as the table summarizing results results across software packages (Table 2 in the publication) .

Patient Dataset results: This contains the original feature values for each software package for each patient dataset (1 lesion per case) as well as the table summarizing results across software packages and patient datasets (Table 3 in the publication).

Harmonized GLCM Entropy Results : This contains the values for the “Harmonized” GLCM Entropy feature for each patient dataset and each software package as well as the summary across software packages (Table 4 in the publication).

Patient IDs for the 3 DROs from (https://doi.org/10.7937/t062-8262)
Phantom-100.0-1.0-1.0-1.0-9.0-0.0-100.0-10.0-0.0-0.0
Phantom-100.0-1.0-1.0-1.0-9.0-0.0-100.0-10.0-50.0-0.0
Phantom-100.0-1.0-1.0-1.0-9.0-0.2-100.0-10.0-0.0-0.0
 
Patient IDs for the 10 LIDC-IDRI subjects (https://doi.org/10.7937/K9/TCIA.2015.LO9QL9SX)
LIDC-IDRI-0314
LIDC-IDRI-0325
LIDC-IDRI-0580
LIDC-IDRI-0766
LIDC-IDRI-0771
LIDC-IDRI-0811
LIDC-IDRI-0905
LIDC-IDRI-0963
LIDC-IDRI-0965
LIDC-IDRI-1012

Additional options for download:


DRO Data (3 subjects)Download all or Query/Filter

Image Data (DICOM, 452.0 MB)

CT only


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urlhttps://wiki.cancerimagingarchive.net/download/attachments/70222123/DRO%20Toolkit-3%20Subjects-DICOM-CT%20Image%20Data%20TCIA%20Manifest.
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labelSearch
urlhttps://nbia.cancerimagingarchive.net/nbia-search/?ImageModalityCriteria=CT&MinNumberOfStudiesCriteria=1&PatientCriteria=Phantom-100.0-1.0-1.0-1.0-9.0-0.0-100.0-10.0-0.0-0.0,Phantom-100.0-1.0-1.0-1.0-9.0-0.0-100.0-10.0-50.0-0.0,Phantom-100.0-1.0-1.0-1.0-9.0-0.2-100.0-10.0-0.0-0.0&CollectionCriteria=DRO-Toolkit

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Segmentation Data - DSO (DICOM, 29.0 MB)


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urlhttps://wiki.cancerimagingarchive.net/download/attachments/70222123/DRO%20Toolkit-3%20Subjects-DICOM-Segmentation%20Data%20TCIA%20Manifest.tcia?api=v2

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labelSearch
urlhttps://nbia.cancerimagingarchive.net/nbia-search/?ImageModalityCriteria=SEG&MinNumberOfStudiesCriteria=1&PatientCriteria=Phantom-100.0-1.0-1.0-1.0-9.0-0.0-100.0-10.0-0.0-0.0,Phantom-100.0-1.0-1.0-1.0-9.0-0.0-100.0-10.0-50.0-0.0,Phantom-100.0-1.0-1.0-1.0-9.0-0.2-100.0-10.0-0.0-0.0&CollectionCriteria=DRO-Toolkit

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Segmentation Data - (NIfTI, zip, 926 KB)


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urlhttps://wiki.cancerimagingarchive.net/download/attachments/70222123/DRO%20Toolkit-3%20Subjects-SEG%20Images%20NIfTI%20.zip?api=v2

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Patient Datasets (10 subjects)Download all or Query/Filter

Image Data (DICOM, 1.0 GB)

CT only


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urlhttps://wiki.cancerimagingarchive.net/download/attachments/70222123/LIDC-IDRI-10%20Subjects-DICOM%20CT%20Image%20Data%20TCIA%20manifest.tcia?api=v2

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urlhttps://nbia.cancerimagingarchive.net/nbia-search/?ImageModalityCriteria=CT&MinNumberOfStudiesCriteria=1&PatientCriteria=LIDC-IDRI-0314,LIDC-IDRI-0325,LIDC-IDRI-0580,LIDC-IDRI-0766,LIDC-IDRI-0771,LIDC-IDRI-0811,LIDC-IDRI-0905,LIDC-IDRI-0963,LIDC-IDRI-0965,LIDC-IDRI-1012&CollectionCriteria=LIDC-IDRI

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Segmentation Data - (DICOM, 94 MB)


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urlhttps://wiki.cancerimagingarchive.net/download/attachments/70222123/LIDC-IDRI-10%20Subjects-DICOM%20SEG%20Image%20Data%20TCIA%20Manifest.tcia?api=v2

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urlhttps://nbia.cancerimagingarchive.net/nbia-search/?saved-cart=nbia-39001586554584246

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Segmentation Data - (NIfTI, zip, 21.0 KB)


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urlhttps://wiki.cancerimagingarchive.net/download/attachments/70222123/LIDC-IDRI-10%20Subjects-NIfTI-Patient_Image_Data_NIFTI_Segs.zip?api=v2

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Localtab
titleCitations & Data Usage Policy

Citations & Data Usage Policy

Tcia limited license policy

Localtab
titleCitations & Data Usage Policy

Citations & Data Usage Policy

Add any special restrictions in here.

These collections are freely available to browse, download, and use for commercial, scientific and educational purposes as outlined in the Creative Commons Attribution 3.0 Unported License. Questions may be directed to help@cancerimagingarchive.net. Please be sure to acknowledge both this data set and TCIA in publications by including the following citations in your work:

Info
titleData Citation

McNitt-Gray, M.*, Napel, S.*, Jaggi, A., Mattonen, S.A., Hadjiiski, L., Muzi, M., Goldgof, D., Balagurunathan, Y., Pierce, L.A., Kinahan, P.E., Jones, E.F., Nguyen, A., Virkud, A., Chan, H-P., Emaminejad, N., Wahi-Anwar, M., Daly, M., Abdalah, M., Yang, H., Lu, L., Lv, W., Rahmim, A., Gastounioti, A., Pati, S., Bakas, S., Kontos, D., Zhao, B., Kalpathy-Cramer, J., Farahani, K. (2020). Data from the  Standardization in Quantitative Imaging: A Multi-center Comparison of Radiomic Features from Different Software Packages on Digital Reference Objects and Patient Datasets. Tomography, Feb, 2020.*Authors contributed equallyFeature Values [Data set]The Cancer Imaging Archive. DOI: https://doi.org/10.7937/tcia.2020.9era-gg29.


Info
titlePublication Citation

Kalpathy-Cramer, J., Zhao, BMcNitt-Gray, M., Napel, S., Jaggi, A., Mattonen, S.A., Hadjiiski, L., Muzi, M., Goldgof, D., Gu, Y., Wang, XBalagurunathan, Y., Pierce, L.A., Kinahan, P.E., Jones, E.F., Nguyen, A., Virkud, A., Chan, H-P., Emaminejad, N., Wahi-Anwar, M., Daly, M., Abdalah, M., Yang, H., … Napel, S. (2016). A Comparison of Lung Nodule Segmentation Algorithms: Methods and Results from a Multi-institutional Study. Journal of Digital Imaging. Springer Nature. http., Lu, L., Lv, W., Rahmim, A., Gastounioti, A., Pati, S., Bakas, S., Kontos, D., Zhao, B., Kalpathy-Cramer, J., Farahani, K. (2020). Standardization in Quantitative Imaging: A Multi-center Comparison of Radiomic Feature Values, Tomography. https://doi.org/10.1007/s10278-016-9859-z18383/j.tom.2019.00031.


Info
titleTCIA Citation

Clark, K., Vendt, B., Smith, K., Freymann, J., Kirby, J., Koppel, P., Moore, S., Phillips, S., Maffitt, D., Pringle, M., Tarbox, L., & Prior, F. (2013).  The Cancer Imaging Archive (TCIA): Maintaining and Operating a Public Information Repository, . Journal of Digital Imaging, Volume 26, Number (6, December, 2013, pp 1045-1057. DOI: ), 1045–1057. https://doi.org/10.1007/s10278-013-9622-7


Info
titleAcknowledgement - Grant Citationssupport
  • David Geffen School of Medicine at UCLA - U01CA181156


Info
titleAcknowledgement - Grant support
  • Stanford University School of Medicine – U01CA187947 and U24CA180927


Info
titleAcknowledgement - Grant support
  • University of Michigan - U01CA232931


Info
titleAcknowledgement - Grant support
  • University of Washington – R50CA211270, U01CA148131


Info
titleAcknowledgement - Grant support
  • University of South Florida - U24CA180927, U01CA200464


Info
titleAcknowledgement - Grant support
  • Moffitt Cancer Center – U01CA143062, U01CA200464, P30CA076292


Info
titleAcknowledgement - Grant support
  • UC San Francisco - U01CA225427


Info
titleAcknowledgement - Grant support
  • BC Cancer Research Centre - NSERC Discovery Grant: RGPIN-2019-06467


Info
titleAcknowledgement - Grant support
  • Columbia University- U01CA225431


Info
titleAcknowledgement - Grant support
  • Center for Biomedical Image Computing and Analytics at the University of Pennsylvania - U24CA189523, R01NS042645


Info
titleAcknowledgement - Grant support
  • Massachusetts General Hospital- U01CA154601, U24CA180927


In addition to the dataset citation above, please be sure to cite the following if you utilize these data in your research:

Info
titleAnalysis Citation

Jayashree Kalpathy-Cramer, J., Sandy Napel, S., Dmitry Goldgof, Binsheng D., Zhao, B. (2015). Multi-site collection of Lung CT data with Nodule Segmentations. The Cancer Imaging Archive. http https://doi.org/10.7937/K9/TCIA.2015.1BUVFJR7


Other Publications Using This Data

TCIA maintains a list of publications which leverage TCIA data. If you have a manuscript you'd like to add please contact the TCIA's Helpdesk.




Localtab
titleVersions

Version 1 (Current): Updated 2020/

03

06/

XX

09

Data TypeDownload all or Query/Filter
Images

Corresponding Original CT images from LIDC-IDRI and DRO-Toolkit (DICOM,

xx

2.

x GB)

Image RemovedImage Removed

(Requires 

0 GB)

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urlhttps://wiki.cancerimagingarchive.net/download/attachments/70222123/Radiomic-Feature-Standards-DICOM%20CTs%203%20Subjects%20DRO%20Toolkit%2010%20Subjects%20QIN.tcia?api=v2

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labelSearch
urlhttps://nbia.cancerimagingarchive.net/nbia-search/?ImageModalityCriteria=CT&MinNumberOfStudiesCriteria=1&PatientCriteria=Phantom-100.0-1.0-1.0-1.0-9.0-0.0-100.0-10.0-0.0-0.0,Phantom-100.0-1.0-1.0-1.0-9.0-0.0-100.0-10.0-50.0-0.0,Phantom-100.0-1.0-1.0-1.0-9.0-0.2-100.0-10.0-0.0-0.0,LIDC-IDRI-0314,LIDC-IDRI-0325,LIDC-IDRI-0580,LIDC-IDRI-0766,LIDC-IDRI-0771,LIDC-IDRI-0811,LIDC-IDRI-0905,LIDC-IDRI-0963,LIDC-IDRI-0965,LIDC-IDRI-1012

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Corresponding second-generation SEG images from QIN-LungCT-Seg (DICOM, 123 MB) 
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urlhttps://wiki.cancerimagingarchive.net/download/attachments/70222123/Radiomic-Feature-Standards-DICOM%20Segs%203%20Subjects%20DRO%20Toolkit%2010%20Subjects%20QIN.tcia?api=v2

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labelSearch
urlhttps://nbia.cancerimagingarchive.net/nbia-search/?ImageModalityCriteria=SEG&MinNumberOfStudiesCriteria=1&PatientCriteria=Phantom-100.0-1.0-1.0-1.0-9.0-0.0-100.0-10.0-0.0-0.0,Phantom-100.0-1.0-1.0-1.0-9.0-0.0-100.0-10.0-50.0-0.0,Phantom-100.0-1.0-1.0-1.0-9.0-0.2-100.0-10.0-0.0-0.0,LIDC-IDRI-0314,LIDC-IDRI-0325,LIDC-IDRI-0580,LIDC-IDRI-0766,LIDC-IDRI-0771,LIDC-IDRI-0811,LIDC-IDRI-0905,LIDC-IDRI-0963,LIDC-IDRI-0965,LIDC-IDRI-1012

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Segmentations (NIfTI, XX.X GB)


Segmentation (NIfTI, zip, 4 MB)


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urlhttps://wiki.cancerimagingarchive.net/download/attachments/70222123/DRO%20Toolkit-3%20Subjects%20SEG%20and%20QIN%20multi-site%2010%20Subjects%20SEG%20NIfTI.zip?api=v2



Feature Variability Software Package details (xlsx)


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urlhttps://wiki.cancerimagingarchive.net/download/attachments/70222123/Table%201%20-%20Feature%20Variability%20Software%20Details_v2.xlsx?api=v2



DRO Results (xlsx)


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urlhttps://wiki.cancerimagingarchive.net/download/attachments/70222123/DRO%20Results%20Table%202%20QIN%20PET%20CT%20WG%20DRO%20Feature%20Values_Table2_supporting_data.xlsx?api=v2



Patient Dataset Results (xlsx)


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urlhttps://wiki.cancerimagingarchive.net/download/attachments/70222123/Patient%20Dataset%20Results%20QIN%20PET%20CT%20WG%20Patient%20Dataset%20Feature%20Values_Table3_supporting_data.xlsx?api=v2



Harmonized GLCM Entropy Results  (xlsx)


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urlhttps://wiki.cancerimagingarchive.net/download/attachments/70222123/Harmonized%20GLCM%20Entropy%20Results%20QIN%20PET%20CT%20WG%20Patient%20Dataset%20Feature%20Values_Table4_supporting_data.xlsx?api=v2
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