Summary
This dataset contains image annotations derived from the NCI Clinical Trial "Combination Chemotherapy and Radiation Therapy in Treating Young Patients With Newly Diagnosed Hodgkin Lymphoma (AHOD0831)”. The key objective of this project is to generate a large and highly curated imaging dataset of pediatric Hodgkin lymphoma patients with annotations suitable for cancer researchers and AI developers.
Annotation Protocol
For each patient, every DICOM Study and DICOM Series was reviewed to identify and annotate the clinically relevant time points and sequences/series. In a typical patient all available time points were annotated:
In a typical patient the following annotation rules were followed:
- PERCIST criteria was followed. Specifically, the lesions estimated to have the most elevated SUVmax were annotated.
- Lesions were annotated in the axial plane. If no axial plane is available, lesions were annotated in the coronal plane.
- Lesions were annotated on the attenuation corrected PET series as well as the diagnostic contrast enhanced CT. If no diagnostic contrast enhanced CT is available for that timepoint, then the non contrast CT portion of the PET/CT was annotated.
- A maximum of 5 lesions were annotated per patient scan (timepoint); no more than 2 per organ. For the purposes of this project, the lymph nodes constitute 1 organ, while other lymphatic structures such as the spleen, salivary glands, and Waldeyer’s ring structures constitute separate organs. The same 5 lesions were annotated at each time point. RECIST 1.1 principles will be followed. Specifically, lymph nodes were annotated if > 1.5 cm in short axis. Other lesions were annotated if > 1 cm.
- Lesions were labeled separately.
- Seed points were automatically generated but reviewed by a radiologist.
At each time point:
- A seed point (kernel) wase created for each segmented structure. The seed points for each segmentation are provided in a separate DICOM RTSS file.
- SNOMED-CT “Anatomic Region Sequence” and “Segmented Property Category Code Sequence” and codes were inserted for all segmented structures.
- “Tracking ID” and “Tracking UID” tags were inserted for each segmented structure to enable longitudinal lesion tracking.
- Imaging time point codes were inserted to help identify each annotation in the context of the clinical trial assessment protocol.
- (255235001, SCT, “Pre-dose”)
- (262502001, SCT, "Post-chemotherapy")
- (262502001, SCT, "Post-chemotherapy")
- (262502001, SCT, "Post-chemotherapy")
- (262502001, SCT, "Post-chemotherapy")
- (262502001, SCT, "Post-chemotherapy")
- (262502001, SCT, "Post-chemotherapy")
- etc.
- “Clinical Trial Time Point ID” was used to encode time point type using one of the following strings as applicable: “pre-dose” or “post-chemotherapy”
- Content Item in “Acquisition Context Sequence” was added containing "Time Point Type" using Concept Code Sequence (0040,A168) selected from:
Data Access
This is a limited access data set. To request access please register an account on the NCTN Data Archive. After logging in, use the "Request Data" link in the left side menu. Follow the on screen instructions, and enter NCT01026220 when asked which trial you want to request. In step 2 of the Create Request form, be sure to select “Imaging Data Requested”. Please contact NCINCTNDataArchive@mail.nih.gov for any questions about access requests.
Data Type | Download all or Query/Filter | License |
---|---|---|
AHOD0831 Annotations -- Segmentations, Seed Points, and Negative Findings Assessments (DICOM, 0.1 GB) | (Download requires NBIA Data Retriever) | |
AHOD0831 Annotation Metadata (CSV) | ||
Original AHOD0831 Images used to create Segmentations and Seed Points (DICOM, 104.1 GB) | (Download requires NBIA Data Retriever) | |
Original AHOD0831 Images used to create Negative Assessment reports (DICOM, 5.7 GB) | (Download requires NBIA Data Retriever) |
Click the Versions tab for more info about data releases.
Additional Resources for this Dataset
- NCTN/NCORP Data Archive provides the Clinical Data files related to these subjects, and is also where you go to request access to the entire dataset
- Jupyter notebook demonstrating how to use the NBIA Data Retriever Command-Line Interface application and REST API (with authentication) to access these data
- Instructions for Visualizing these data in 3D Slicer
Collections Used in this Third Party Analysis
Below is a list of the Collections used in these analyses:
Detailed Description
Image Statistics | |
---|---|
Modalities | RTSTRUCT |
Number of Patients | 165 |
Number of Studies | 1089 |
Number of Series | 5135 |
Number of Images | 5135 |
Images Size (GB) | 0.1 |
Citations & Data Usage Policy
Users must abide by the TCIA Data Usage Policy and Restrictions. Attribution should include references to the following citations:
Data Citation
Rozenfeld, M., & Jordan, P. (2023). Annotations for Combination Chemotherapy and Radiation Therapy in Treating Young Patients With Newly Diagnosed Hodgkin Lymphoma (AHOD0831-Tumor-Annotations) [Data set]. The Cancer Imaging Archive. https://doi.org/10.7937/4QAD-4280
TCIA Citation
Clark, K., Vendt, B., Smith, K., Freymann, J., Kirby, J., Koppel, P., Moore, S., Phillips, S., Maffitt, D., Pringle, M., Tarbox, L., & Prior, F. (2013). The Cancer Imaging Archive (TCIA): Maintaining and Operating a Public Information Repository. In Journal of Digital Imaging (Vol. 26, Issue 6, pp. 1045–1057). Springer Science and Business Media LLC. https://doi.org/10.1007/s10278-013-9622-7
Other Publications Using This Data
TCIA maintains a list of publications which leverage TCIA data. If you have a manuscript you'd like to add please contact the TCIA Helpdesk.
Version 1 (Current): Updated 2023/02/10
Data Type | Download all or Query/Filter | License |
---|---|---|
AHOD0831 Annotations -- Segmentations, Seed Points, and Negative Findings Assessments (DICOM, 0.1 GB) | (Download requires the NBIA Data Retriever) | |
AHOD0831 Annotation Metadata (CSV) | ||
Original AHOD0831 Images used to create Segmentations and Seed Points (DICOM, 104.1 GB) | (Download requires the NBIA Data Retriever) | |
Original AHOD0831 Images used to create Negative Assessment reports (DICOM, 5.7GB) | (Download requires the NBIA Data Retriever) |