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Data Access

This is a limited access data set. To request access please register an account on the NCTN Data Archive.  After logging in, use the "Request Data" link in the left side menu.  Follow the on screen instructions, and enter NCT00392327 NCT00379340 when asked which trial you want to request.  In step 2 of the Create Request form, be sure to select “Imaging Data Requested”. Please contact NCINCTNDataArchive@mail.nih.gov for any questions about access requests.

Click the Versions tab for more info about data releases.

• NCTN/NCORP Data Archive provides the Clinical Data files related to these subjects, and is also where you go to request access to the entire dataset
• Jupyter notebook demonstrating how to use the NBIA Data Retriever Command-Line Interface application and our REST API (with authentication) to access these data
• Instructions for Visualizing these data in 3D Slicer

Collections Used in this Third Party Analysis

Below is a list of the Collections used in these analyses:

• Combination Chemotherapy With or Without Radiation Therapy in Treating Young Patients With Newly Diagnosed Stage III or Stage IV Wilms Tumor (AREN0533)

Detailed Description

Important information contained in the DICOM headers:

1. Anatomic Region Sequence (0x0008, 0x2218) was inserted containing CNS Segmentation Types as defined in: https://dicom.nema.org/medical/dicom/current/output/chtml/part16/sect_CID_7153.html. In cases where tumor spans multiple regions, multiple location codes were inserted. For example, if the tumor is centered in the parietal lobe, but also involves the frontal and temporal lobes, anatomical codes for all three locations were attached to the structure.
2. Segmented Property Category Code Sequence (0x0062,0x0003) was inserted into DICOM SEG objects containing one of the following codes:
   • (NCIt, C113842, "Enhancing Lesion")
   • (NCIt, C81175, "Non-Enhancing Lesion")
   • (SNOMED-CT, 14799000, "Neoplasm, Secondary")
   • (SNOMED-CT, 79654002, "Edema")
3. Tracking ID (0x0062,0x0020) and Tracking UID (0x0062,0x0021) tags were inserted for each segmented structure to enable longitudinal lesion tracking.
4. A study time point description was inserted into the Clinical Trial Time Point ID (0x0012,0x0050) attribute to help identify each annotation in the context of the clinical trial assessment protocol. The time point description contains one of the following strings: pre-operative, post-operative, post-radiation, post-chemotherapy, or recurrence. Additionally, a Concept Name Code Sequence (0x0040, 0xA043) and Concept Code Sequence (0x0040,0xA168) were added to Acquisition Context Sequence (0x0040, 0x0555).The former defines a Time Point Type concept and latter is populated with one of the following concepts:
   • (SNOMED-CT, 262068006, "Pre-operative")
   • (SNOMED-CT, 262061000, "Post-operative")
   • (SNOMED-CT, 264908009, "Post-radiation")
   • (SNOMED-CT, 262502001, "Post-chemotherapy")
   • (SNOMED-CT, 25173007, "Recurrent tumor (finding)")
5. For reviewed studies with no radiologic findings, a "negative" DICOM SEG and/or RTSS file are provided. These files contain no segmentation or contour data, but still contain pertinent metadata in Clinical Trial Time Point ID, Acquisition Context Sequence, Anatomic Region Sequence, and Segmented Property Category Code Sequence. The primary motivation for providing these annotations is to capture the information that no radiologic findings (e.g. progression or new metastatic disease) were found during review.

Citations & Data Usage Policy

Other Publications Using This Data

TCIA maintains a list of publications which leverage TCIA data. If you have a manuscript you'd like to add please contact the TCIA Helpdesk.

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