Summary
This dataset contains image annotations derived from the NCI Clinical Trial "Combination Chemotherapy With or Without Radiation Therapy in Treating Young Patients With Newly Diagnosed Stage III or Stage IV Wilms Tumor (AREN0533)”. This dataset was generated as part of an NCI project to augment TCIA datasets with annotations that will improve their value for cancer researchers and AI developers.
Annotation Protocol
For each patient, every DICOM Study and DICOM Series was reviewed to identify and annotate the clinically relevant time points and sequences. In a typical patient the following time points were annotated:
- Pre-treatment CT chest and abdomen
- CT chest and/or CT abdomen at 6 weeks
- Possible CT abdomen at 12 weeks.
In a typical patient the following annotation rules were followed:
- The primary renal tumor(s) were annotated on post-contrast axial series. Normal renal parenchyma were excluded.
- A maximum of 5 lesions were annotated per patient scan (timepoint); no more than 2 per organ. The same 5 lesions were annotated at each time point.
- RECIST 1.1 principles were generally followed for lesion annotation, however if <5 lesions measuring >1 cm were present, then smaller lesions were annotated, again up to 2 lesions per organ or 5 lesions per patient scan.
- Bone lesions were included if other lesions were not present.
- To ensure a high standard of accuracy and data quality, each annotation was reviewed by a secondary reader.
At each timepoint:
- Volumetric segmentations, seed points and negative finding assessments (DICOM RTSTRUCT) were created.
- SNOMED-CT “Anatomic Region Sequence” and “Segmented Property Category Code Sequence” and codes were inserted for all segmented structures.
- Imaging time point codes were inserted to help identify each annotation in the context of the clinical trial assessment protocol.
- “Clinical Trial Time Point ID” was used to encode time point type using one of the following strings as applicable: “pre-dose” or “post-chemotherapy”.
- The Content Item in “Acquisition Context Sequence” was added containing "Time Point Type" using Concept Code Sequence (0040,A168) selected from:
- (255235001, SCT, “Pre-dose”)
- (262502001, SCT, "Post-chemotherapy")
Important supplementary information and sample code
- A spreadsheet containing key details about the annotations is available in the Data Access section below.
- A Jupyter notebook demonstrating how to use the NBIA Data Retriever Command-Line Interface application and the REST API (with authentication) to access these data can be found in the Additional Resources section below.
Data Access
Data Type | Download all or Query/Filter | License |
---|---|---|
AREN0533 Annotations -- Segmentations, Seed Points, and Negative Findings Assessments (DICOM, 0.1 GB) | (Download requires NBIA Data Retriever) | |
AREN0533 Annotation Metadata (CSV) | ||
Original AREN0533 Images used to create Segmentations and Seed Points (DICOM, 50.3 GB) | (Download requires NBIA Data Retriever) | |
Original AREN0533 Images used to create Negative Assessment reports (DICOM, 3.4 GB) | (Download requires NBIA Data Retriever) |
Click the Versions tab for more info about data releases.
Additional Resources for this Dataset
- NCTN/NCORP Data Archive provides the Clinical Data files related to these subjects, and is also where you go to request access to the entire dataset
- Jupyter notebook demonstrating how to use the NBIA Data Retriever Command-Line Interface application and REST API (with authentication) to access these data
- Instructions for Visualizing these data in 3D Slicer
Collections Used in this Third Party Analysis
Below is a list of the Collections used in these analyses:
Detailed Description
Image Statistics | |
---|---|
Modalities | RTSTRUCT |
Number of Patients | 294 |
Number of Studies | 660 |
Number of Series | 3025 |
Number of Images | 3025 |
Images Size (GB) | 0.1 GB |
Citations & Data Usage Policy
Users must abide by the TCIA Data Usage Policy and Restrictions. Attribution should include references to the following citations:
Data Citation
Rozenfeld, M., & Jordan, P. (2023). Annotations for Combination Chemotherapy With or Without Radiation Therapy in Treating Young Patients With Newly Diagnosed Stage III or Stage IV Wilms Tumor (AREN0533-Tumor-Annotations) [Data set]. The Cancer Imaging Archive. https://doi.org/10.7937/WFCC-DA41
TCIA Citation
Clark, K., Vendt, B., Smith, K., Freymann, J., Kirby, J., Koppel, P., Moore, S., Phillips, S., Maffitt, D., Pringle, M., Tarbox, L., & Prior, F. (2013). The Cancer Imaging Archive (TCIA): Maintaining and Operating a Public Information Repository. In Journal of Digital Imaging (Vol. 26, Issue 6, pp. 1045–1057). Springer Science and Business Media LLC. https://doi.org/10.1007/s10278-013-9622-7
Other Publications Using This Data
TCIA maintains a list of publications which leverage TCIA data. If you have a manuscript you'd like to add please contact the TCIA Helpdesk.
Version 1 (Current): Updated 2023/01/31
Data Type | Download all or Query/Filter | License |
---|---|---|
AREN0533 Annotations -- Segmentations, Seed Points, and Negative Findings Assessments (DICOM, 0.1 GB) | (Download requires the NBIA Data Retriever) | |
AREN0533 Annotation Metadata (CSV) | ||
Original AREN0533 Images used to create Segmentations and Seed Points (DICOM, 50.3 GB) | (Download requires the NBIA Data Retriever) | |
Original AREN0533 Images used to create Negative Assessment reports (DICOM, 3.7 GB) | (Download requires the NBIA Data Retriever) |