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• The ACRIN 6657 trial team   (((MAKE LINK TO FULL LIST )))
• The I-SPY 1 TRIAL team    (((MAKE LINK TO FULL LIST )))
• All the patients participating in these studies

((( END OF PUBLIC PAGE - REST GOES ON SEPARATE PAGE ACCESSIBLE TO THOSE WITH STUDY DOWNLOAD PRIVILEDGES  )))

I-SPY 1 / ACRIN 6657 - Collection Description

If you are unsure how to download this Collection please view Searching by Collection or refer to The Cancer Imaging Archive User's Guide for more detailed instructions on using the site.

Imaging Data Transfer Process

The processing of the MR image data for ACRIN 6657 consisted of the following steps between image acquisition and the creation of this shared data set on TCIA:

• MRI studies were sent from the study centers to the ACRIN Core Lab either via media (DVD) or the TRIAD program
• Image data were de-identified and centrally archived at the ACRIN Core Lab
• Archived data was sent to the Breast Imaging Research Program (BIRP) at the University of California, San Francisco (UCSF) for volumetric analysis.
• De-identified image data, derived analysis maps and segmentations, and ancillary data files were transferred from UCSF to TCIA for data sharing.

While every effort was made to preserve the integrity of both the original image data and image meta-data (DICOM attributes, public and private), multiple file transfers and strict adherence to HIPPA guidelines for patient confidentiality may have resulted in loss of some data. If any questions arise, or patient PHI is found in any data on this collection, please contact David Newitt at the Breast Imaging Research Program, UCSF (david.newitt@ucsf.edu). 

Curated Data Sets

Summary

In addition to the complete set of ACRIN 6657 imaging studies ("Level 0" data), curated data sets based on UCSF QC assessment, protocol compliance and data completeness are provided for download in the form of TCIA shared lists. These include:

• Level 1:    MRI Longest Diameter (LD)
• Level 2a:  SER Volume Dataset for pCR (updated 9/13/14)
• Level 2b:  SER Volume Dataset for pCR Analysis (Hylton, et al; Radiology 2012)
• Level 3:    SER Volume Dataset for RFS Analysis (Hylton, et al; Radiology, accepted)

The image data sets are accompanied by Excel files with patient clinical and outcome data.

Level 0: All I-SPY 1 / ACRIN 6657 Dataset

847 MR on-study studies (222 subjects) in UCSF image database.
One patient in the image data collection (I-SPY ID 1079 ) does not appear in the Feb. 2, 2011 I-SPY FINAL LOCKED clinical data set. So no clinical data is available.

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Studies with MRI measured longest diameter
839 MR studies have LD reported in the I-SPY 1 clinical database
834 MR studies (219 subjects) in UCSF image database with LD

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Level 2a consists of 708 MR studies (208 subjects) in the UCSF image database which, following quality review in 2014, were judged to have sufficiently good image quality and protocol compliance for volumetric DCE SER analysis. Rejection criteria included: incomplete volumetric DCE acquisitions, lack of a 2nd post-contrast acquisition, variability in fat suppression across the image, observed patient motion during the DCE acquisition

• Patient 1079 does not appear in the Feb. 2, 2011 I-SPY FINAL LOCKED clinical data set. So no clinical data is available.

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This data is comprised of the patient studies analyzed and reported to ACRIN in 2008, and used for the 2012 Radiology paper on ACRIN 6657 *. This data set is not provided as a shared list, as it is not recommended for use in further analysis. It is described here because it is the data set from which the Level 3 (primary aim analysis) set was derived.

Level 2b consists of 707 MR studies (207 subjects) in the UCSF image database which were submitted to ACRIN at the close of the trial in 2008. Inclusion and exclusion was determined by quality and protocol reviews available at that time. In addition to the exclusion criteria listed for Level 2a, studies done with imaging in the axial plane, in violation of the sagittal orientation specified in the trial imaging protocol, were excluded due to processing limitations of the analysis software. Similarly, bi-lateral sagittal acquisitions (alternating left and right volumetric acquisitions) were excluded.

• Hylton NM, Blume JD, Bernreuter WK, et al: Locally advanced breast cancer: MR imaging for prediction of response to neoadjuvant chemotherapy--results from ACRIN 6657/I-SPY TRIAL. Radiology 263:663-72, 2012

Specific inclusion/exclusion differences between Levels 2a and 2b:

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586 MR studies (162 subjects) in UCSF image database

Shared Lists For Curated Data Sets

To download image data sets for the curated data sets go to Tools / Search Shared Lists after logging in TCIA, and search for "ISPY1"

Shared lists have been created for each of the main curated data sets: Level 1, 2a, and 3. For each level one may download either:

"All Series"               full MRI datasets including all original series and derived PE, SER maps and segmentation objects from the primary analysis

"DCE + Derived"      Original DCE series and derived PE, SER maps and segmentation objects from the primary analysis

"DCE Only"              Original DCE series only

Relative sizes of the lists and full collection are shown in the Table below. Estimated download times can be found by loading the shared list into the download manager from the Search Shared Lists tool. Links are also provided in the Table for Excel spreadsheet files containing selected patient clinical and outcome data for the patients in each set. Further data will be made available in the future as it is released by I-SPY. Outcome data may not be accessible by all users.

To download: Tools / Search Shared Lists

I-SPY 1 / ACRIN 6657 Data Dictionaries