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  • The ACRIN 6657 trial team   (((MAKE LINK TO FULL LIST )))
  • The I-SPY 1 TRIAL team    (((MAKE LINK TO FULL LIST )))
  • All the patients participating in these studies


I-SPY 1 / ACRIN 6657 - Collection Description

If you are unsure how to download this Collection please view Searching by Collection or refer to The Cancer Imaging Archive User's Guide for more detailed instructions on using the site.

Imaging Data Transfer Process

The processing of the MR image data for ACRIN 6657 consisted of the following steps between image acquisition and the creation of this shared data set on TCIA:

  • MRI studies were sent from the study centers to the ACRIN Core Lab either via media (DVD) or the TRIAD program
  • Image data were de-identified and centrally archived at the ACRIN Core Lab
  • Archived data was sent to the Breast Imaging Research Program (BIRP) at the University of California, San Francisco (UCSF) for volumetric analysis.
  • De-identified image data, derived analysis maps and segmentations, and ancillary data files were transferred from UCSF to TCIA for data sharing.

While every effort was made to preserve the integrity of both the original image data and image meta-data (DICOM attributes, public and private), multiple file transfers and strict adherence to HIPPA guidelines for patient confidentiality may have resulted in loss of some data. If any questions arise, or patient PHI is found in any data on this collection, please contact David Newitt at the Breast Imaging Research Program, UCSF ( 

In addition to the complete set of ACRIN 6657 imaging studies ("Level 0" data), curated data sets based on UCSF QC assessment, protocol compliance and data completeness are provided for download in the form of TCIA shared lists. These include:

  • Level 1:    MRI Longest Diameter (LD)
  • Level 2a:  SER Volume Dataset for pCR (updated 9/13/14)
  • Level 2b:  SER Volume Dataset for pCR Analysis (Hylton, et al; Radiology 2012)
  • Level 3:    SER Volume Dataset for RFS Analysis (Hylton, et al; Radiology, accepted)

The image data sets are accompanied by Excel files with patient clinical and outcome data.

Level 0: All I-SPY 1 / ACRIN 6657 Dataset

847 MR on-study studies (222 subjects) in UCSF image database.
One patient in the image data collection (I-SPY ID 1079 ) does not appear in the Feb. 2, 2011 I-SPY FINAL LOCKED clinical data set. So no clinical data is available.


Studies with MRI measured longest diameter
839 MR studies have LD reported in the I-SPY 1 clinical database
834 MR studies (219 subjects) in UCSF image database with LD

5 studies that have LD measurement are missing from
the UCSF and ACRIN TRIAD image data collections:

1071, T1
1138, T1

1101, T3
1040, T4

1187, T4


Level 2a consists of 708 MR studies (208 subjects) in the UCSF image database which, following quality review in 2014, were judged to have sufficiently good image quality and protocol compliance for volumetric DCE SER analysis. Rejection criteria included: incomplete volumetric DCE acquisitions, lack of a 2nd post-contrast acquisition, variability in fat suppression across the image, observed patient motion during the DCE acquisition

7 studies in Level 2a that do NOT have LD measures:

ID 1059, T4
ID 1079, T2 *
ID 1104, T4

ID 1192, T2
ID 1212, T4

ID 1215, T1
ID 1238, T2

  • Patient 1079 does not appear in the Feb. 2, 2011 I-SPY FINAL LOCKED clinical data set. So no clinical data is available.


This data is comprised of the patient studies analyzed and reported to ACRIN in 2008, and used for the 2012 Radiology paper on ACRIN 6657 *. This data set is not provided as a shared list, as it is not recommended for use in further analysis. It is described here because it is the data set from which the Level 3 (primary aim analysis) set was derived.

Level 2b consists of 707 MR studies (207 subjects) in the UCSF image database which were submitted to ACRIN at the close of the trial in 2008. Inclusion and exclusion was determined by quality and protocol reviews available at that time. In addition to the exclusion criteria listed for Level 2a, studies done with imaging in the axial plane, in violation of the sagittal orientation specified in the trial imaging protocol, were excluded due to processing limitations of the analysis software. Similarly, bi-lateral sagittal acquisitions (alternating left and right volumetric acquisitions) were excluded.

  • Hylton NM, Blume JD, Bernreuter WK, et al: Locally advanced breast cancer: MR imaging for prediction of response to neoadjuvant chemotherapy--results from ACRIN 6657/I-SPY TRIAL. Radiology 263:663-72, 2012

Specific inclusion/exclusion differences between Levels 2a and 2b:

15 studies accepted for SER analysis since 2008 (in Level 2a but not in 2b)

ID 1005, T3
ID 1043, T2
ID 1046, T4
ID 1057, T3
ID 1074, T3
ID 1084, T1

ID 1110, T4
ID 1139, T4
ID 1159, T4
ID 1176, T2
ID 1201, T2

ID 1203, T4
ID 1206, T4
ID 1225, T3
ID 1219, T3
ID 1228, T4

14 studies rejected since 2008 (in Level 2b but not in 2a)

ID 1035, T4 *
ID 1045, T1
ID 1047, T1 *
ID 1053, T2 *
ID 1053, T4 *

ID 1055, T1 *
ID 1086, T1 *
ID 1091, T1 *
ID 1095, T2 *
ID 1173, T3 *

ID 1206, T1
ID 1206, T2
+2 exams for ineligible patient:
ACRIN ID 128 (no I-SPY ID)

* Subjects that were included in the primary aim analysis (Level 3)


586 MR studies (162 subjects) in UCSF image database

45 subjects excluded from Level 2b set

ID 1027

ID 1040

ID 1045

ID 1046

ID 1048

ID 1054

ID 1063

ID 1067

ID 1079

ID 1084

ID 1103

ID 1110

ID 1120

ID 1137

ID 1139

ID 1152

ID 1157

ID 1159

ID 1160

ID 1167

ID 1171

ID 1176

ID 1177

ID 1180

ID 1182

ID 1185

ID 1187

ID 1189

ID 1192

ID 1194

ID 1203

ID 1206

ID 1210

ID 1212

ID 1214

ID 1215

ID 1219

ID 1221

ID 1222

ID 1228

ID 1234

ID 1235

ID 1237

ID 1238



Case  #: 128

Shared Lists For Curated Data Sets

To download image data sets for the curated data sets go to Tools / Search Shared Lists after logging in TCIA, and search for "ISPY1"

Shared lists have been created for each of the main curated data sets: Level 1, 2a, and 3. For each level one may download either:

"All Series"               full MRI datasets including all original series and derived PE, SER maps and segmentation objects from the primary analysis

"DCE + Derived"      Original DCE series and derived PE, SER maps and segmentation objects from the primary analysis

"DCE Only"              Original DCE series only

Relative sizes of the lists and full collection are shown in the Table below. Estimated download times can be found by loading the shared list into the download manager from the Search Shared Lists tool. Links are also provided in the Table for Excel spreadsheet files containing selected patient clinical and outcome data for the patients in each set. Further data will be made available in the future as it is released by I-SPY. Outcome data may not be accessible by all users.




All Series

N / Size

DCE + Derived

N / Size

N DCE Only

N / Size

Clinical dataOutcome data
Level 0: Complete image data set2227880 / 76GBNANALevel 0 ClinicalLevel 0 Outcomes
Level 1: Studies with MRI LD measurements2197778 / 75GBNANALevel 1 ClinicalLevel 1 Outcomes
Level 2a: Studies with SER Volume measurements2086971 / 63GB4022 / 43GB1243 / 24GBLevel 2a ClinicalLevel 2a Outcomes
Level 3: Studies used in primary aim analysis1625696 / 49GB

3223 / 34GB

961 / 18GBLevel 3 ClinicalLevel 3 Outcomes

To download: Tools / Search Shared Lists

I-SPY 1 / ACRIN 6657 Data Dictionaries


DICOM data dictionaryDescriptions of all private DICOM attributes used in the derived maps and segmentations generated by the volumetric analysis and QC evaluations and included in the shared image data set
Patient Clinical data dictionarySelected demographic and clinical data fields included with this shared image data set.
Patient Outcome data dictionarySelected outcome fields, including pCR and survival data, included with this shared image data set