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In addition, this section contains papers, presentations, and videos from the genomics/clinical perspectives which may be of interest to the lung imaging group.
- Li, Y., Zhang, L., Ball, R.L., Liang, X., Li, J., Lin, Z. and Liang, H. (2012) Comparative analysis of somatic copy-number alterations across different human cancer types reveals two distinct classes of breakpoint hotspots. Hum Mol Genet. 21(22):4957-4965. View PubMed abstract
- Sproul, D., Kitchen, R.R., Nestor, C.E., Dixon, J.M., Sims, A.H., Harrison, D.J., Ramsahoye, B.H. and Meehan, R.R. (2012) Tissue of origin determines cancer-associated CpG island promoter hypermethylation patterns. Genome Biol. 13(10):R84. Read the full article
- Greulich, H., Kaplan, B., Mertins, P., Chen, T.H., Tanaka, K.E. Yun, C.H., Zhang, X., Lee, S.H., Cho, J., Ambrogio, L., et al. (2012) Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2. Proc Natl Acad Sci U S A. 109(36):14476-14481. View PubMed abstract
- Liu, P., Morrison, C., Wang, L., Xiong, D., Vedell, P., Cui, P., Hua, X., Ding, F., Lu, Y., James M, et al. (2012) Identification of somatic mutations in non-small cell lung carcinomas using whole-exome sequencing. Carcinogenesis. 33(7):1270-1276 . View PubMed abstract
- Shinjo, K., Okamoto, Y., An, B., Yokoyama, T., Takeuchi, I., Fujii, M., Osada, H., Usami, N., Hasegawa, Y., Ito, H., et al. (2012) Integrated analysis of genetic and epigenetic alterations reveals CpG island methylator phenotype associated with distinct clinical characters of lung adenocarcinoma. Carcinogenesis. 33(7):1277-1285. View PubMed abstract
- Andreopoulos, B. and Anastassiou, D. (2012) Integrated analysis reveals hsa-miR-142 as a representative of a lymphocyte-specific gene expression and methylation signature. Cancer Inform. 11 61-75. Read the full article
- Zhuang, J., Jones, A., Lee, S.-H., Ng, E., Fiegl, H., Zikan, M., Cibula, D., Sargent, A., Salvesen, H., Jacobs, I.J., et al. (2012) The dynamics and prognostic potential of DNA methylation changes at stem cell gene loci in women's cancer. PLoS Genet. 8(2):e1002517. Read the full article
- Yao, C., Li, H., Shen, X., He, Z., He, L. and Guo, Z. (2012) Reproducibility and concordance of differential DNA methylation and gene expression in cancer. PLoS One. 7(1):e29686. Read the full article
- Lin, K., Taylor, J.R. Jr., Wu, T.D., Gutierrez, J., Elliott, J.M., Vernes, J.M., Koeppen, H., Phillips, H.S., de Sauvage, F.J. and Meng, Y.G. (2011) TMEFF2 is a PDGF-AA binding protein with methylation-associated gene silencing in multiple cancer types including glioma. PLoS One. 6(4):e18608. Read the full article
TCGA 2nd Annual Symposium