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  • Radiomic Biomarkers in Oropharyngeal Carcinoma (OPC-Radiomics)

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Oropharynx cancer is increasing in frequency in North America. More refined risk stratification and treatment personalization strategies are needed to improve cure rates and limit toxicities. Radomic features have shown promise for prognostication in oropharynx cancer based on datasets including hundreds of patients. Clinical outcomes data for oropharynx cancer patients treated at Princess Margaret Cancer Centre is of the highest quality, collected prospectively at the point of care. This data has resulted in the recent AJCC/UICC 8th edition staging system for oropharynx cancer (first published by O'Sullivan et al. in Lancet Oncology, 2016 [PMID 26936027]). By making publicly available the published data from our institution, which has now been published twice, we will empower researchers to perform meta-analysis and validation exercises of prognostic radiomic models. Ultimately this will lead to more robust models and bring us closer to clinical implementation and impact for our patients.

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