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# animals in Group | # animals that displayed metastasis in MRI and confirmed by Pathology | Pathology confirmation of MRI (primary imaging site) | Other confirmed Location (s) |
10 (non-resected) | 4 (5 mice were EU due to xenograft size prior to observation of metastases) | Lung | Lung |
10 (resected) | 10 | Lung | Lung, Kidney, Nodes, Peritoneal Wall |
Percent penetrance with respect to the average time-to-metastasis for non-resected (plot A: time from implant) and resected (plot B: time from tumor resection) cohorts.
PET/CT Characterization of the primary tumor: Baseline PET (SOP attached) were performed when tumor reached an approximate 200 mm3. Average SUVmax values (n=5) were calculated; [18F]FDG: 1.3 ± 0.2 and [18F]FLT: 2.3 ± 0.6.
Conclusion:
Excellent metastatic model with at least 50% penetrance un-resected and 100% with planned early resection. Metastases are well observed on T2 MRI imaging allowing non-invasive evaluation in treatment trials.
Acknowledgements
We would like to acknowledge the individuals and institutions that have provided data for this collection:
Frederick National Laboratory for Cancer Research – Special Thanks to Joseph D. Kalen, PhD, Lilia V. Ileva, MS, Lisa A Riffle, Nimit Patel, Keita Saito, PhD, Yvonne Evrard, PhD, Elijah Edmondson, DVM, PhD, Jessica Phillips, Simone Difilippantonio, PhD, Chelsea Sanders, Amy Janes, Lia Thang, Ulrike Wagner, Yanling Liu, PhD, John B. Freymann, and Justin Kirby.
Division of Cancer Therapeutics and Diagnosis/National Cancer Institute - James L. Tatum, MD, Paula M Jacobs, PhD, Melinda G. Hollingshead, DVM, and James H. Doroshow, MD
PixelMed Publishing – Special Thanks to David A. Clunie, MD
University of Arkansas for Medical Sciences – Special Thanks to Kirk E. Smith
This project has been funded in whole or in part with Federal funds from the National Cancer Institute, National Institutes of Health, under Contract No. HHSN261201500003I. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government.
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