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Some overviews to get you started with DICOM medical image data like those in TCIA include:

 

A number of research papers using TCIA data have reported using MATLAB in their analyses.

See this link: https://wiki.cancerimagingarchive.net/dosearchsite.action?queryString=MATLAB

 

 

 

And here are links to helpful information about using TCIA.

https://wiki.cancerimagingarchive.net/display/Public/Frequently+Asked+Questions

https://wiki.cancerimagingarchive.net/display/Public/Searching+by+Collection

https://wiki.cancerimagingarchive.net/display/Public/The+Cancer+Imaging+Archive+User's+Guide