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As a brief history, the American College of Radiology Imaging Network (ACRIN) started in 1999 as National Cancer Institute (NCI) funded clinical trials cooperative group. The motivation for forming ACRIN was the growing importance of imaging to cancer care [1]. Major trials included the National Lung Screening Trial (NLST, listed as ACRIN 6654) [2] and The Digital Mammography Screening Trial (DMIST, listed as ACRIN 6652) [3]. However, in total there were roughly 50 imaging trials, all with clinical data and outcomes. Imaging modalities included MRI, CT, x-ray, mammography, and PET. In 2012 ACRIN merged with the Eastern Cooperative Oncology Group (ECOG) to become ECOG-ACRIN and imaging based trials have continued. Upon request, ACRIN (and now ECOG-ACRIN) provides access to data, after publication of the primary aim.
A full list of clinical trial imaging data sets that originated from the NCI National Clinical Trials Network (NCTN) that are avaialbe on TCIA are listed here.
which is a collection of organizations and clinicians that coordinates and supports cancer clinical trials at more than 3,000 sites across the United States and Canada. The NCTN provides the infrastructure for NCI-funded treatment, screening, and diagnosis trials to improve the lives of patients with cancer. The NCTN explicitly requires data sharing of the patient-level clinical data in https://nctn-data-archive.nci.nih.gov/view-trials, and TCIA serves as the imaging repository for that archive.
In 2015, ECOG-ACRIN was awarded a grant from NCI for "ECOG-ACRIN-Based QIN Resource for Advancing Quantitative Cancer Imaging in Clinical Trials" to support research resources for the NCI-funded Quantitative Imaging Network (QIN ). The QIN is a collective of NCI funded groups from roughly two dozen centers with a technical and clinical focus of developing robust methods to predict and/or measure response to therapy and encourage their broad dissemination within the imaging, oncology, and device industry communities [4].
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