The goal of the BMMR2 challenge is challenge was to identify image-based markers derived from DW-MRI, alone or in combination with DCE-MRI, with improved performance over whole-tumor mean ADC for predicting pCR following neoadjuvant chemotherapy (NAC) for invasive breast cancer. The challenge is being was run by the Breast Imaging Research Program of UCSF through the NCI Quantitative Imaging Network (QIN). The challenge opened on June 1, 2021 and will run for six months. closed on December 1, 2021.
Data for the challenge will consist consisted of a subset of the TCIA the TCIA breast MRI collection from the American College of Radiology Imaging Network (ACRIN) trial 6698. 573 breast MRI studies from 191 subjects undergoing NAC for invasive breast cancer will be were provided, with the patient the patient cohort split 60%/40% into training and test groups. pCR pCR outcome data will be was provided for the training set. A brief description of the data set is provided below. For more information on the ACRIN 6698 collection see the TCIA collection description at at ACRIN 6698/I-SPY2 Breast DWI (ACRIN 6698). For more information on and to register for the challenge please visit the challenge hosting site MedICI Challenges. After registration at MedICI you will be provided access to the challenge data collection downloads from TCIA.The challenge was hosted by MedICI Challenges.
ACRIN 6698
The primary aim of ACRIN 6698 was the evaluation of quantitative breast diffusion weighted imaging (DWI) for the prediction of response to neoadjuvant chemotherapy (NAC) for invasive breast cancer. For this purpose, serial MRI studies were acquired over the course of NAC in patients with locally advanced breast cancer. The study schema for the ACRIN 6698 Trial is shown in Figure 1 below. ACRIN 6698 was performed at 10 imaging centers as a sub-study of the ongoing I-SPY 2 TRIAL (Investigation of Serial studies to Predict Your Therapeutic Response with Imaging And moLecular Analysis 2); an adaptive, multi-agent phase II trial designed to quickly identify new agents for breast cancer. I-SPY 2 utilizes serial MRI studies to monitor treatment response during NAC and to inform the adaptive randomization engine assigning patients to one of multiple control or experimental drug arms.
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MRI studies performed during the course of NAC at three of the standard I-SPY 2 imaging time points will be were available for the challenge:
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Both original images and derived maps and segmentations from the DWI and DCE acquisitions are included in the collection
Links
Information and registration for the BMMR2 challenge: MedICI Challenges
Information on the ACRIN 6698 data collection: ACRIN 6698/I-SPY2 Breast DWI (ACRIN-6698)
Information on I-SPY 2 TRIAL: I-SPY 2 TRIAL
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