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Summary

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locationhttps://www.cancerimagingarchive.net/collection/a091105/

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This collection contains data from the Children’s Oncology Group (COG) Alliance for Clinical Trials in Oncology Clinical Trial NCT02066181  "Sorafenib “Sorafenib Tosylate in Treating Patients With Desmoid Tumors or Aggressive Fibromatosis".   Principal Investigator: Mrinal M Gounder (Alliance for Clinical Trials in Oncology).  It . It was sponsored by NCI and performed by the Children's Oncology Group Alliance for Clinical Trials in Oncology under study number A091105.   This randomized phase III trial compares the effects, good and/or bad, of sorafenib tosylate in treating patients with desmoid tumors or aggressive fibromatosis. Sorafenib tosylate may stop the growth of tumor cells by blocking some of the proteins needed for cell growth. [Funding Source - FDA OOPD]  Select Select patient-level clinical data from this trial is available via the following link:  https://nctn-data-archive.nci.nih.gov/node/1266.

Trial Outcomes  

Results of the trial have been reported in the following publications:

  • Mazza GL, Petersen MM, Ginos B, Langlais BT, Heon N, Gounder MM, Mahoney MR, Zoroufy AJ, Schwartz GK, Rogak LJ, Thanarajasingam G, Basch E, Dueck AC. Missing data strategies for the Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE) in Alliance A091105 and COMET-2. Qual Life Res. 2022 Apr;31(4):1069-1080. doi: 10.1007/s11136-021-02968-1. Epub 2021 Aug 21. Erratum in: Qual Life Res. 2021 Oct 11.
  • Basch E, Becker C, Rogak LJ, Schrag D, Reeve BB, Spears P, Smith ML, Gounder MM, Mahoney MR, Schwartz GK, Bennett AV, Mendoza TR, Cleeland CS, Sloan JA, Bruner DW, Schwab G, Atkinson TM, Thanarajasingam G, Bertagnolli MM, Dueck AC. Composite grading algorithm for the National Cancer Institute's Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE). Clin Trials. 2021 Feb;18(1):104-114. doi: 10.1177/1740774520975120. Epub 2020 Dec 1.
  • Gounder MM, Mahoney MR, Van Tine BA, Ravi V, Attia S, Deshpande HA, Gupta AA, Milhem MM, Conry RM, Movva S, Pishvaian MJ, Riedel RF, Sabagh T, Tap WD, Horvat N, Basch E, Schwartz LH, Maki RG, Agaram NP, Lefkowitz RA, Mazaheri Y, Yamashita R, Wright JJ, Dueck AC, Schwartz GK. Sorafenib for Advanced and Refractory Desmoid Tumors. N Engl J Med. 2018 Dec 20;379(25):2417-2428. doi: 10.1056/NEJMoa1805052. 


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titleData Access

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titleData Access

Data Access

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Additional Resources for this Dataset

The following external resources have been made available by the data submitters.  These are not hosted or supported by TCIA, but may be useful to researchers utilizing this collection.

  • Software / Code on Github
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titleDetailed Description

Detailed Description

Image Statistics

Radiology Image StatisticsPathology Image Statistics

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Number of Patients

8783

Number of Studies

1140

Number of Series

11977

Number of Images

722626

Images Size (GB)
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titleCitations & Data Usage Policy

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titleData Citation

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titlePublication Citation

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Gounder, M. M., Mahoney, M. R., Van Tine, B. A., Ravi, V., Attia, S., Deshpande, H. A., Gupta, A. A., Milhem, M. M., Conry, R. M., Movva, S., Pishvaian, M. J., Riedel, R. F., Sabagh, T., Tap, W. D., Horvat, N., Basch, E., Schwartz, L. H., Maki, R. G., Agaram, N. P., … Schwartz, G. K. (2023). Sorafenib Tosylate in Treating Patients With Desmoid Tumors or Aggressive Fibromatosis (A091105) (Version 1) [Data set]. The Cancer Imaging Archive. https://doi.org/10.7937/0WF5-SJ50


Info
titlePublication Citation

Gounder, M. M., Mahoney, M. R., Van Tine, B. A., Ravi, V., Attia, S., Deshpande, H. A., Gupta, A. A., Milhem, M. M., Conry, R. M., Movva, S., Pishvaian, M. J., Riedel, R. F., Sabagh, T., Tap, W. D., Horvat, N., Basch, E., Schwartz, L. H., Maki, R. G., Agaram, N. P., … Schwartz, G. K. (2018). Sorafenib for Advanced and Refractory Desmoid Tumors. In New England Journal of Medicine (Vol. 379, Issue 25, pp. 2417–2428). Massachusetts Medical Society. https://doi.org/10.1056/nejmoa1805052

Info
titleAcknowledgement

Required acknowledgements only (ex:The CPTAC program requests that publications using data from this program...). If they just want to thank someone, that goes in the Acknowledgement section underneath the Summary.


Info
titleTCIA Citation

Clark, K., Vendt, B., Smith, K., Freymann, J., Kirby, J., Koppel, P., Moore, S., Phillips, S., Maffitt, D., Pringle, M., Tarbox, L., & Prior, F.  (2013). The Cancer Imaging Archive (TCIA): Maintaining and Operating a Public Information Repository, . In Journal of Digital Imaging , Volume (Vol. 26, Number Issue 6, December, 2013, pp 1045-1057. DOI: pp. 1045–1057). Springer Science and Business Media LLC. https://doi.org/10.1007/s10278-013-9622-7

Other Publications Using This Data

TCIA maintains a list of publications which leverage TCIA data. If you have a manuscript you'd like to add please contact the TCIA Helpdesk.


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titleVersions

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1 (Current): Updated

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2023/

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Data TypeDownload all or Query/FilterLicense
Images, Segmentations, and Radiation Therapy Structures/Doses/Plans

Images  (DICOM,

XX.X

279 GB)

<< latter two items only if DICOM SEG/RTSTRUCT/RTDOSE/PLAN exist >>


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urlhttps://wiki.cancerimagingarchive.net/download/attachments/127664238/A091105%20February%202023%20manifest.tcia?api=v2
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